Results 81 to 90 of about 334,081 (324)

Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins

Journal of Lipid Research, 2012
Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease plasma apoB, LDL cholesterol (LDL-C), and triglycerides.
Jeremy D. Furtado, Mark K. Wedel, Frank M. Sacks   +2 more
doaj  

Association of Different Combinations of ALDH2 rs671, APOE rs429358, rs7412 Polymorphisms with Hypertension in Middle-Aged and Elderly People: A Case–Control Study

International Journal of General Medicine, 2023
Xinping Lan,1– 3 Zhenchang Wang,3,4 Zifeng Zeng,1– 3 Huaqing Yao,1– 3 Weiyong Xu,1– 3 Yuxian Zhang1– 3 1Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Guangdong ...
Lan X, Wang Z, Zeng Z, Yao H, Xu W, Zhang Y   +5 more
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Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Retinal regions shape human and murine Müller cell proteome profile and functionality

Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023
Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan, Corinne Drexler, Anna M. Pfaller, Santra Brenna, Kirsten A. Wunderlich, Andrea Dimitracopoulos, Juliane Merl‐Pham, Maria‐Theresa Perez, Ursula Schlötzer‐Schrehardt, Volker Enzmann, Marijana Samardzija, Berta Puig, Peter Fuchs, Kristian Franze, Stefanie M. Hauck, Antje Grosche   +15 more
wiley   +1 more source

Bosnian study of APOE distribution (BOSAD): a comparison with other European populations

Annals of Human Biology, 2017
Background: The ε2, ε3 and ε4 alleles of APOE gene have been associated with several diseases in different populations. Data on the frequency of alleles are used in both a clinical and evolutionary context. Although the data on frequency of these alleles
Grażyna Adler, Mateusz A. Adler, Anna Urbańska, Karolina Skonieczna-Żydecka, Emina Kiseljakovic, Amina Valjevac, Miłosz Parczewski, Almira Hadzovic-Dzuvo   +7 more
doaj   +1 more source

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Deletion of MyD88 in astrocytes prevents β‐amyloid‐induced neuropathology in mice

Glia, Volume 71, Issue 2, Page 431-449, February 2023., 2023
Main Points MyD88 is upregulated in astrocytes in Alzheimer's disease. Deletion of MyD88 in astrocytes protects against β‐amyloid‐induced synaptic toxicity and cognitive impairment in mice. Abstract As the understanding of immune responses in Alzheimer's disease (AD) is in its early phases, there remains an urgency to identify the cellular and ...
Tee Jong Huat, Tessa Onraet, Judith Camats‐Perna, Estella A. Newcombe, Kim C. Ngo, Ashley N. Sue, Mehdi Mirzaei, Frank M. LaFerla, Rodrigo Medeiros   +8 more
wiley   +1 more source

Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population

Pharmacogenomics and Personalized Medicine, 2023
Yaqi Wang,1,* Shuang Yang,1,* Suya Zhang,1,* Xiaoyu Lu,2 Wenbing Ma1,2 1Department of Pharmacology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, People’s Republic of China; 2Department of Biological ...
Wang Y, Yang S, Zhang S, Lu X, Ma W
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Single‐Cell Analysis Clarifies Pathological Heterogeneity in Tenosynovial Giant Cell Tumor and Identifies Biomarkers for Predicting Disease Recurrence

Advanced Science, EarlyView.
MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie, Chen Chen, Fei Wu, Yiman Peng, Jing Su, Yang Zhao, Hongjie Huang, Zhong Alan Li, Yin Pei, Wencui Li, Yi He, Tianchen Xue, Chenxi Cao, Sui Peng, Xin Zhang, Weidong Song   +15 more
wiley   +1 more source

Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease

Guoji laonian yixue zazhi
Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current
Jiayuan Li, Ting Liu, Shengxi Meng
doaj   +1 more source