The lysophosphatidylcholine-HIF-1α axis enhances apolipoprotein E sialylation and promotes electronegative LDL accumulation. [PDF]
Chan HC +11 more
europepmc +1 more source
ABSTRACT Mendelian randomisation (MR) is an approach to causal inference that uses genetic variants to infer whether or not a causal effect exists, unbiased by unobserved confounding. MR estimation usually considers the effect of a single exposure on an outcome; it has recently been extended to explore potential effects of multiple exposures using ...
Ciarrah‐Jane Barry +5 more
wiley +1 more source
People living with HIV on modern antiretrovirals do not display a pro-atherogenic lipid profile and have similar body composition compared to healthy controls. [PDF]
Savinelli S +11 more
europepmc +1 more source
High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor
Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn +6 more
wiley +1 more source
Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI. [PDF]
Escudero B +5 more
europepmc +1 more source
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez +8 more
wiley +1 more source
Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. [PDF]
Reijnders E +17 more
europepmc +1 more source
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck +4 more
wiley +1 more source
Lipid Profile, Apolipoproteins, and Impulsivity in First Episode Mania. [PDF]
Behera R +4 more
europepmc +1 more source
Contrast Agents for Enhanced Bioimaging: A Comprehensive Review
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube +17 more
wiley +1 more source

