Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]
AIMS Neuroscience, 2018 Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Ziphozethu Ndlazi +3 more
doaj +4 more sources
Identification of the efficacy and safety of apomorphine in the treatment of Parkinson’s disease via meta-analysis [PDF]
BMC NeurologyBackground The majority of Parkinson’s disease (PD) patients experience motor fluctuations and dyskinesias as the disease progresses. Apomorphine has been used as an acute treatment for off episodes in PD in recent years.
Haidong Li +3 more
doaj +2 more sources
The prevalence of impulsive compulsive behaviors in patients treated with apomorphine infusion: a retrospective analysis [PDF]
Arquivos de Neuro-Psiquiatria, 2021 Background: Impulsive compulsive behaviors (ICBs) can affect a significant number of Parkinson’s disease (PD) patients. Objective: We have studied brain samples from a brain bank of PD patients who received apomorphine via continuous infusion in life to
Pedro Barbosa +3 more
doaj +2 more sources
Licensed Subcutaneous Infusion Therapies in Advanced Parkinson’s Disease: An Indirect Treatment Comparison and Cost-Minimisation Analysis [PDF]
Neurology and TherapyIntroduction Parkinson’s disease is the second most common neurodegenerative disorder. In advanced Parkinson’s disease, subcutaneous (SC) infusion therapies represent minimally invasive and reversible treatment options.
Marc Vérin +9 more
doaj +2 more sources
Ophthalmic ropinirole is an equally effective emetic agent in healthy dogs compared to intravenous apomorphine [PDF]
Frontiers in Veterinary ScienceIntroductionEmesis is commonly induced in the veterinary setting due to toxin or foreign material ingestion. The dopamine agonist apomorphine is commonly used for this indication.
Jack A. Lee +3 more
doaj +2 more sources
Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis [PDF]
AntioxidantsThe role of ferroptosis in steatohepatitis development is largely unknown. We investigated (1) whether hepatocyte ferroptosis occurs in a gene-modified steatohepatitis model without modifying dietary components, (2) whether ferroptosis occurs at an early
Hiroshi Maeda +10 more
doaj +2 more sources
Behavioural Neurology, 1996 Short-latency somatosensory evoked potentials (SSEPs) were recorded from 10 parkinsonian patients in ‘off’ and ‘on’ states induced by apomorphine and levodopa.
M. Miranda, J. L. Castillo, F. Araya
doaj +3 more sources
Apomorphine for prolonged disorders of consciousness: a multimodal open-label studyResearch in context [PDF]
EClinicalMedicineSummary: Background: Apomorphine is a dopaminergic candidate therapy to improve recovery in patients with prolonged disorders of consciousness (PDoC). Behavioural improvements were previously described in non-controlled case series, but its efficacy and
Leandro R.D. Sanz +18 more
doaj +2 more sources
Insights into retention and safety/tolerability of apomorphine sublingual film in patients with Parkinson's disease and OFF episodes: post hoc analyses of a phase III, open-label study. [PDF]
Ther Adv Neurol DisordKassubek J +8 more
europepmc +2 more sources
Clinical and Translational Science, 2021 Apomorphine is an on‐demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD). A joint parent‐metabolite population pharmacokinetic (PK) model characterized apomorphine and apomorphine‐sulfate following administration of apomorphine ...
Felix Agbo +6 more
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