Results 31 to 40 of about 26,023 (245)
Continuous subcutaneous apomorphine monotherapy in Parkinson’s disease
Annals of Agricultural and Environmental Medicine, 2019 Introduction and objective Continuous subcutaneous apomorphine (APO) treatment is one of the 3 therapeutic options for advanced Parkinson’s disease (PD), in addition to deep brain stimulation (DBS) and intrajejunal levodopa.
Ewa Papuć +2 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Parkinson’s disease (PD) is a common neurodegenerative disease. At present, 5–10% of PD patients are found to have monogenic form of the disease. Each genetic mutation has its own unique clinical features and disease trajectory.
Germaine Hiu-Fai Chan
doaj +1 more source
Brain Sciences, 2022 Involvement of the dopaminergic (DA) and hypothalamic-pituitary-thyroid (HPT) systems in suicidal behavior is still poorly understood. We assessed multihormonal responses to apomorphine (APO; a short acting DA receptor agonist) and 8 AM and 11 PM ...
Fabrice Duval +5 more
doaj +1 more source
Costs of Parkinson's Disease and Antiparkinsonian Pharmacotherapy: An Italian Cohort Study [PDF]
, 2010 Objective: Antiparkinsonian pharmacotherapy is costly and the determinants of drug costs in Parkinson's disease (PD) have been poorly investigated. The objective of this study was to investigate the costs of PD and antiparkinsonian drugs in an Italian ...
Balzer-Geldsetzer, Monika +10 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 2005 Apomorphine is a dopamine receptor agonist proposed to be a neuroprotective agent in the treatment of patients with Parkinson's disease. Both in vivo and in vitro studies have shown that apomorphine displays both antioxidant and pro-oxidant actions, and ...
J.N. Picada +2 more
doaj +1 more source
Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus [PDF]
, 2001 We studied the control of dorsal raphe (DR) serotonergic neurons by dopaminergic transmission in rat brain using microdialysis and single unit extracellular recordings. Apomorphine (0.5–3.0 mg/kg s.c.) and quinpirole (0.5 mg/kg s.c.) increased serotonin (
Artigas, Francesc +4 more
core +1 more source
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Clinical trial evaluating apomorphine oromucosal solution in Parkinson's disease patients
Clinical and Translational ScienceApomorphine, used to treat OFF episodes in patients with Parkinson's disease (PD), is typically administered via subcutaneous injections. Administration of an oromucosal solution could offer a non‐invasive and user‐friendly alternative.
Eva Thijssen +8 more
doaj +1 more source
Relationship of Dopamine of the Nucleus Accumbens with Intra-infralimbic Apomorphine Microinjection [PDF]
Iranian Journal of Basic Medical Sciences, 2013 Objective(s): The dopamine level of the nucleus accumbens changes during some stereotyped behaviors. To study dopamine level of the nucleus accumbens in intra infralimbic apomorphine-induced climbing, microdialysis probes were implanted into the nucleus ...
Abbas Alimoradian +4 more
doaj
Distinction and mutual Influences between Parkinson's Disease‐related and unrelated Chronic Pain
Movement Disorders Clinical Practice, EarlyView.Abstract Background Chronic pain (i.e. > 3 months) is a common nonmotor symptom in patients with Parkinson's disease (PD), but the attribution to PD is critical for further treatment. Objectives We explored the PD Pain Classification System (PD‐PCS) criteria for the diagnosis of PD‐related pain and mutual influences between PD‐related and PD‐unrelated ...
Jonathan Hunger +11 more
wiley +1 more source