Results 51 to 60 of about 75 (74)
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A NOTE ON APOMORPHINE AS A SEDATIVE
American Journal of Psychiatry, 1945This note stresses the value of apomorphine as a sedative in the agitation and excitement accompanying certain psychiatric illnesses. The dosages, indications, contraindications and complications are discussed.
S. Eugene Barrera +2 more
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Diurnal responsiveness to apomorphine
Neurology, 1987Many parkinsonian patients respond to L-dopa better in the morning than at other times. To explore the possibility that this phenomenon represents diurnal fluctuations in dopaminergic receptor responsiveness, we compared the effects of subcutaneously administered apomorphine during "off" periods in the mornings and afternoons in nine fluctuating ...
Stephen T. Gancher, John G. Nutt
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Journal of Pharmaceutical Sciences, 1961
The auto-oxidation product of apomorphine has been isolated. On the basis of elemental analysis, spectral evidence, as well as solubility and chromatographic behavior, it appears to be devoid of nitrogen, possibly an 8-substituted phenanthrene-3,4-dione. A scheme is suggested for the degradative process. The decomposition product has no emetic property.
E. Brochmann-Hanssen, P.N. Kaul
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The auto-oxidation product of apomorphine has been isolated. On the basis of elemental analysis, spectral evidence, as well as solubility and chromatographic behavior, it appears to be devoid of nitrogen, possibly an 8-substituted phenanthrene-3,4-dione. A scheme is suggested for the degradative process. The decomposition product has no emetic property.
E. Brochmann-Hanssen, P.N. Kaul
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Proerectile effects of apomorphine in mice
Life Sciences, 2003Dopaminergic pathways play a key role in the central control of sexual behavior. Stimulation of central dopaminergic receptors elicits penile erection in a variety of species and has been proposed as a treatment option for erectile dysfunction in humans. The present study investigated the proerectile effects of apomorphine in mice.
Rampin, Olivier +2 more
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Biological Disposition of Apomorphine IV. Isolation and Characterization of “Bound” Apomorphine
Journal of Pharmaceutical Sciences, 1961“Bound” apomorphine, the major metabolic product of apomorphine, has been isolated from the urine of rabbits by a series of ion exchange procedures, fractionated by paper chromatography, and identified by enzymatic hydrolysis and various color tests.
E. Leong Way +2 more
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European Journal of Pharmacology, 1973
Abstract Apomorphine undergoes O-methylation in rat liver. Apocodeine, the methylated product, can be identified by paper chromatography. The catechol-O-methyltransferase inhibitors, pyrogallol and 3,4-dimethoxy-5-hydroxy-benzoic acid prolong apomorphine-induced stereotyped behaviour (ASB). This suggest that O-methylation is an important route in the
Samarthji Lal +2 more
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Abstract Apomorphine undergoes O-methylation in rat liver. Apocodeine, the methylated product, can be identified by paper chromatography. The catechol-O-methyltransferase inhibitors, pyrogallol and 3,4-dimethoxy-5-hydroxy-benzoic acid prolong apomorphine-induced stereotyped behaviour (ASB). This suggest that O-methylation is an important route in the
Samarthji Lal +2 more
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Biological Disposition of Apomorphine III
Journal of Pharmaceutical Sciences, 1961A method for estimation of free and “bound” apomorphine in biologic media is described. Apomorphine, after parenteral administration to different animal species, is biotransformed and excreted in urine largely in its “bound” form. Studies on the organ-distribution of injected apomorphine in rats revealed a localization of “bound” apomorphine in the ...
E. Leong Way +2 more
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Effect of apomorphine on human sleep
Life Sciences, 1978Abstract The effect of intravenous infusion of apomorphine in non emetic doses (10–15 μg/min) on the sleep of ten subjects was studied. During apomorphine infusion for 180 minutes, a complete suppression of REM sleep and a dramatic reduction of the amount of delta sleep occurred.
CIANCHETTI C +4 more
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Effects of apomorphine on exploration
Physiology & Behavior, 1972Abstract An attempt is made to analyse those effects of apomorphine usually described as stereotyped motor patterns, including, in rats, sniffing. Following a suggestion that this could reflect a raised reactivity rather than a mere motor disturbance, an experiment is presented which indicates that apomorphine induces heightened and prolonged ...
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Clinical Toxicology, 1976