Results 11 to 20 of about 1,427,266 (249)

Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence

Frontiers in Cell and Developmental Biology, 2021
The main challenge in the treatment of acute myeloid leukemia (AML) is relapse, as it has no good treatment options and 90% of relapsed patients die as a result.
Eimear O’Reilly, Hojjat Alizadeh Zeinabad, Caoimhe Nolan, Jamileh Sefy, Thomas Williams, Marina Tarunina, Diana Hernandez, Yen Choo, Eva Szegezdi   +8 more
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Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Molecular Therapy: Oncolytics, 2018
Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize
Shawn T. Beug, Stephanie J. Pichette, Martine St-Jean, Janelle Holbrook, Danielle E. Walker, Eric C. LaCasse, Robert G. Korneluk   +6 more
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C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy

Nature Communications, 2023
The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang, Mindan Tong, Denghao Zheng, Huiying Huang, Linsen Li, Christian Ungermann, Yi Pan, Hanyan Luo, Ming Lei, Zaiming Tang, Wan Fu, She Chen, Xiaoxia Liu, Qing Zhong   +13 more
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Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Nature Communications, 2018
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali   +18 more
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Suspension-Induced Stem Cell Transition: A Non-Transgenic Method to Generate Adult Stem Cells from Mouse and Human Somatic Cells

Cells, 2023
Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated and
Behzad Yeganeh, Azadeh Yeganeh, Kyle Malone, Shawn T. Beug, Robert P. Jankov   +4 more
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Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing

Bio-Protocol, 2017
The three-dimensional organisation of cells in a tissue and their interaction with adjacent cells and extracellular matrix is a key determinant of cellular responses, including how tumour cells respond to stress conditions or therapeutic drugs (Elliott ...
Mark Watters , Eva Szegezdi
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Comprehensive Mutation Profiling of Colorectal Cancer Patients With Lung or Liver Metastasis by Targeted Next-Generation Sequencing

Technology in Cancer Research & Treatment, 2023
Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD, Jing-Long Wang MD, Ting Hou MD, Zhao-Wen Yan MD, Li-Dong Zu PhD, Guo-Hui Fu PhD, Wei-Wei Shen PhD   +6 more
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The Proanthocyanidin-Rich Fraction Obtained from Red Rice Germ and Bran Extract Induces HepG2 Hepatocellular Carcinoma Cell Apoptosis

Molecules, 2019
This study aims to determine the anti-carcinogenic effects of the proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract on HepG2 cells.
Supranee Upanan, Supachai Yodkeeree, Pilaiporn Thippraphan, Wanisa Punfa, Rawiwan Wongpoomchai, Pornngarm Limtrakul (Dejkriengkraikul)   +5 more
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Photoablation at single cell resolution and its application in the Drosophila epidermis and peripheral nervous system

Frontiers in Physiology, 2023
Tissues contain diverse cell populations that, together, make up physiologically functional units. A remarkable example is the animal epidermis, where neuronal and non-neuronal cells intermingle to allow somatosensory perception.
Federica Mangione, Rocco D’Antuono, Nicolas Tapon   +2 more
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Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis.
Meng Li, Yujie Han, Chaochen Wang, Wenfeng Kang, Wenyan Jiang, Lei Zhang, Yujie Tang   +6 more
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