Results 11 to 20 of about 1,961,106 (365)
The Oncologist, 1999 Mechanisms in Hematology is a book with an accompanying interactive CD-ROM designed to assemble basic concepts that underlie clinical understanding and progress. It is presented as a concise text with a series of diagrams that distill diffuse information into a compact form.
Esther D. Israels, Lyonel G. Israels and
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Inhibitor of apoptosis proteins and apoptosis [PDF]
Acta Biochimica et Biophysica Sinica, 2008 Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats.
Yunbo Wei, Tingjun Fan, Miaomiao Yu
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Introduction to Apoptosis [PDF]
Diagnostic Molecular Pathology, 1995 Kerr and colleagues (II) coined the term" apoptosis" to designate a particular form of cell death distinct from necrosis. The salient features of apoptosis, which Kerr defined in histopathologic terms, were the breakup of individual cells into smaller, often round or ovoid cytoplasmic fragments containing pyknotic nuclear debris, called" apoptotic ...
Diaz-Cano, Salvador J., R N Salomon
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Academic Emergency Medicine, 1998 Abstract. Apoptosis is a process of cell suicide, the mechanisms of which are encoded in the genomes of all higher eukaryotes. The mechanisms involved in apoptosis suggest that the process is based on a viral defense originally developed in primitive multicelled eukaryotes and that the fundamental execution platform of the process involves 1 ...
B C, White, J M, Sullivan
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Scientific Reports, 2021 CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu +3 more
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The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Frontiers in Oncology, 2022 Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies.
Shan Qian +5 more
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SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis [PDF]
Apoptosis 22 (11), 1336-1343 (2017), 2017 Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we characterize the progression of apoptosis in wild type
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Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death [PDF]
Apoptosis (2010), 2010 BH3 mimetics have been proposed as new anticancer therapeutics. They target anti-apoptotic Bcl-2 proteins, up-regulation of which has been implicated in the resistance of many cancer cells, particularly leukemia and lymphoma cells, to apoptosis. Using probabilistic computational modeling of the mitochondrial pathway of apoptosis, verified by single ...
arxiv +1 more source
Nature Communications, 2017 Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer ...
Shawn T. Beug +16 more
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Caspases: the executioners of apoptosis.
Biochemical Journal, 1997 Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes a protein required for developmental cell death.
G. Cohen
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