Results 11 to 20 of about 1,221,178 (144)
Nature Communications, 2017 Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer ...
Shawn T. Beug +16 more
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Bone, 2013 Apoptotic death of osteocytes was recognized over 15 years ago, but its significance for bone homeostasis has remained elusive. A new paradigm has emerged that invokes osteocyte apoptosis as a critical event in the recruitment of osteoclasts to a specific site in response to skeletal unloading, fatigue damage, estrogen deficiency and perhaps in other ...
Robert L, Jilka +2 more
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Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
International Journal of Cell Biology, 2010 During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death.
Sanjeev Gupta +6 more
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Molecular Therapy: Oncolytics, 2018 Smac mimetic compounds (SMCs) are anti-cancer drugs that antagonize Inhibitor of Apoptosis proteins, which consequently sensitize cancer cells to death in the presence of proinflammatory ligands such as tumor necrosis factor alpha (TNF-α). SMCs synergize
Shawn T. Beug +6 more
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Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence
Frontiers in Cell and Developmental Biology, 2021 The main challenge in the treatment of acute myeloid leukemia (AML) is relapse, as it has no good treatment options and 90% of relapsed patients die as a result.
Eimear O’Reilly +8 more
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Nature Communications, 2023 The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang +13 more
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Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing
Bio-Protocol, 2017 The three-dimensional organisation of cells in a tissue and their interaction with adjacent cells and extracellular matrix is a key determinant of cellular responses, including how tumour cells respond to stress conditions or therapeutic drugs (Elliott ...
Mark Watters , Eva Szegezdi
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Cells, 2023 Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated and
Behzad Yeganeh +4 more
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Technology in Cancer Research & Treatment, 2023 Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD +6 more
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Inhibitor of apoptosis proteins and apoptosis [PDF]
Acta Biochimica et Biophysica Sinica, 2008 Apoptosis is a physiological cell death process that plays a critical role in development, homeostasis, and immune defense of multicellular animals. Inhibitor of apoptosis proteins (IAPs) constitute a family of proteins that possess between one and three baculovirus IAP repeats.
Yunbo, Wei, Tingjun, Fan, Miaomiao, Yu
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