Results 21 to 30 of about 1,961,106 (365)
Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization
International Journal of Cell Biology, 2010 During apoptosis, the process of mitochondrial outer membrane permeabilization (MOMP) represents a point-of-no-return as it commits the cell to death.
Sanjeev Gupta +6 more
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Recreating the Bone Marrow Microenvironment to Model Leukemic Stem Cell Quiescence
Frontiers in Cell and Developmental Biology, 2021 The main challenge in the treatment of acute myeloid leukemia (AML) is relapse, as it has no good treatment options and 90% of relapsed patients die as a result.
Eimear O’Reilly +8 more
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Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs) [PDF]
Cells, 2013 Inhibitors of Apoptosis (IAPs) are a family of proteins with various biological functions including regulation of innate immunity and inflammation, cell proliferation, cell migration and apoptosis. They are characterized by the presence of at least one N-terminal baculoviral IAP repeat (BIR) domain involved in protein-protein interaction.
Jean Berthelet, Laurence Dubrez
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Nature Communications, 2023 The multi-subunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for autophagosome-lysosome fusion in mammals, yet reconstituting the mammalian HOPS complex remains a challenge.
Shen Zhang +13 more
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British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
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Apoptosis and inflammation [PDF]
Mediators of Inflammation, 1995 During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972) introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the ...
I. Vermes, C. Haanen
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Model for Osteosarcoma-9 as a Potent Factor in Cell Survivor and Resistance to Apoptosis [PDF]
Phys. Rev. E 76, 011926 (2007), 2006 In this paper we use a simple toy model to explore the function of the gene Osteosarcoma-9. We are in particular interested in understanding the role of this gene as a potent anti-apoptotic factor. The theoretical description is constrained by experimental data from induction of apoptosis in cells where OS-9 is overexpressed. The data available suggest
arxiv +1 more source
BCL-2 family members and the mitochondria in apoptosis.
Genes & Development, 1999 A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
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Molecules, 2019 This study aims to determine the anti-carcinogenic effects of the proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract on HepG2 cells.
Supranee Upanan +5 more
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Technology in Cancer Research & Treatment, 2023 Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD +6 more
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