Results 21 to 30 of about 2,974,203 (387)
Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Molecular Cancer, 2023 Background Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. Methods To identify responsible surface proteins, we performed
Ehsan Bahrami +20 more
doaj +1 more source
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
British Journal of Cancer, 1972 The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations.
John F. R. Kerr +3 more
semanticscholar +1 more source
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
Frontiers in Oncology, 2022 Apoptosis, as a very important biological process, is a response to developmental cues or cellular stress. Impaired apoptosis plays a central role in the development of cancer and also reduces the efficacy of traditional cytotoxic therapies.
Shan Qian +5 more
semanticscholar +1 more source
Targeting apoptosis signaling in pancreatic cancer [PDF]
, 2011 The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis.
Fulda, Simone
core +2 more sources
Academic Emergency Medicine, 1998 Abstract. Apoptosis is a process of cell suicide, the mechanisms of which are encoded in the genomes of all higher eukaryotes. The mechanisms involved in apoptosis suggest that the process is based on a viral defense originally developed in primitive multicelled eukaryotes and that the fundamental execution platform of the process involves 1 ...
B C, White, J M, Sullivan
openaire +2 more sources
Scientific Reports, 2021 CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia cells and xenografts derived thereof (PDX).
Wen-Hsin Liu +3 more
doaj +1 more source
Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]
, 2009 : Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
A Cuconati +56 more
core +4 more sources
Preventing effect of vitamin E on oocytes apoptosis in morphinetreated mice [PDF]
, 2013 Several studies have shown that Morphine Sulfate affects on fertility, embryogenesis and consequent pregnancy loss and ultrastructural alterations of oocytes in animal model.
Asadi, E. +3 more
core +1 more source
Investigating the evolution of apoptosis in malaria parasites: the importance of ecology [PDF]
, 2010 Apoptosis is a precisely regulated process of cell death which occurs widely in multicellular organisms and is essential for normal development and immune defences.
Colegrave, Nick +4 more
core +2 more sources
Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane [PDF]
, 2002 p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 ...
Bourdon, J.-C. +4 more
core +4 more sources