Results 41 to 50 of about 2,974,203 (387)
British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
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Caspases: the executioners of apoptosis.
Biochemical Journal, 1997 Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes a protein required for developmental cell death.
G. Cohen
semanticscholar +1 more source
Apoptosis and inflammation [PDF]
Mediators of Inflammation, 1995 During the last few decades it has been recognized that cell death is not the consequence of accidental injury, but is the expression of a cell suicide programme. Kerr et al. (1972) introduced the term apoptosis. This form of cell death is under the influence of hormones, growth factors and cytokines, which depending upon the receptors present on the ...
I. Vermes, C. Haanen
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Molecules, 2019 This study aims to determine the anti-carcinogenic effects of the proanthocyanidin-rich fraction (PRFR) obtained from red rice germ and bran extract on HepG2 cells.
Supranee Upanan +5 more
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Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
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Generation of Tumour-stroma Minispheroids for Drug Efficacy Testing
Bio-Protocol, 2017 The three-dimensional organisation of cells in a tissue and their interaction with adjacent cells and extracellular matrix is a key determinant of cellular responses, including how tumour cells respond to stress conditions or therapeutic drugs (Elliott ...
Mark Watters , Eva Szegezdi
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Technology in Cancer Research & Treatment, 2023 Objectives Primary tumor tissue is often analyzed to search for predictive biomarkers and DNA-guided personalized therapies, but there is an incomplete understanding of the discrepancies in the genomic profiles between primary tumors and metastases, such
Chun-Ting Hu PhD +6 more
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Cells, 2023 Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated and
Behzad Yeganeh +4 more
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Ceramide is a Mediator of Apoptosis in Retina Photoreceptors [PDF]
, 2006 PURPOSE. The precise mechanisms involved in photoreceptor apoptosis are still unclear. We here investigated the role of ceramide, a sphingolipid precursor that induces apoptosis upon cellular stress, in activating this death in photoreceptors.
Abrahan, Carolina Elizabeth +3 more
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