Results 121 to 130 of about 2,944,585 (366)

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

Central regulation of sodium appetite

Experimental Physiology, 2008
Sodium appetite, the behavioural drive to ingest salt, is stimulated by prolonged physiological sodium deficiency in many animal species. The same neural mechanisms that are responsible for sodium appetite in laboratory animals may influence human behaviour as well, with particular relevance to the dietary salt intake of patients with diseases such as ...
Joel C. Geerling, Arthur D. Loewy
openaire   +3 more sources

An fMRI dataset for appetite neural correlates in people living with Motor Neuron Disease

Scientific Data
The dataset investigates the neural correlates of appetite in people living with motor neuron disease (plwMND) compared to non-neurodegenerative disease controls.
Jeryn Chang, JingLei Lv, Christine C. Guo, Diana Lucia, Saskia Bollmann, Kelly Garner, Pamela A. McCombe, Robert D. Henderson, Thomas B. Shaw, Frederik J. Steyn, Shyuan T. Ngo   +10 more
doaj   +1 more source

Energy balance, body composition, sedentariness and appetite regulation: pathways to obesity.

Clinical science, 2016
Energy balance is not a simple algebraic sum of energy expenditure and energy intake as often depicted in communications. Energy balance is a dynamic process and there exist reciprocal effects between food intake and energy expenditure.
Mark Hopkins, J. Blundell
semanticscholar   +1 more source

Regulation of Food Intake : A Complex Process [PDF]

, 2018
Researchers have created a wealth of knowledge about the mechanisms that regulate food intake, appetite and therefore weight control. The control of appetite is a complex mechanism and involves the coordination of inputs from both physiological and ...
Jain, Swati, Singh, Som Nath
core   +2 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

The gut–brain axis in appetite, satiety, food intake, and eating behavior: Insights from animal models and human studies

Pharmacology Research & Perspectives
The gut–brain axis plays a pivotal role in the finely tuned orchestration of food intake, where both homeostatic and hedonic processes collaboratively control our dietary decisions.
Georgia S. Clarke, Amanda J. Page, Sally Eldeghaidy   +2 more
doaj   +1 more source

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT(2C) receptor mediated appetite [PDF]

, 2016
Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic ...
Burke, LK, Davies, JR, Furby, HV, Garfield, AS, Heisler, LK, Isles, AR, Wilkinson, LS   +6 more
core  

Hunger and Satiety Mechanisms and Their Potential Exploitation in the Regulation of Food Intake [PDF]

, 2016
Acknowledgments Tehmina Amin is the Project Manager and Julian Mercer is Project Coordinator for Full4Health. Both are funded by the Full4Health project (grant agreement no. 266408) under the EU Seventh Framework Programme (FP7/2007–2013).
Amin, Tehmina, Mercer, Julian G.
core   +2 more sources

Towards Green Growth Capability Development: A Knowledge‐Based Perspective

Business Strategy and the Environment, EarlyView.
ABSTRACT Green growth, which balances a firm's growth aspirations with environmental stewardship, is gaining traction in the literature. However, the notion of green growth capability (GGC) as a foundation for firm‐level green growth strategy remains underexplored.
Polina Baranova, Hassam Waheed, Fred Paterson   +2 more
wiley   +1 more source