Results 151 to 160 of about 2,944,585 (366)

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

The Role of Peptides in Appetite Regulation Across Species [PDF]

, 1995
John E. Morley
openalex   +1 more source

Appetite, gut hormone and energy intake responses to low volume sprint interval and traditional endurance exercise. [PDF]

, 2013
Sprint interval exercise improves several health markers but the appetite and energy balance response is unknown. This study compared the effects of sprint interval and endurance exercise on appetite, energy intake and gut hormone responses.
A Flint, A Warren, CB Scott, Charlotte E. Connon, DA Thompson, David J. Stensel, DE Cummings, DR Broom, E Børsheim, E Ghigo, E Karra, EC Freese, GA Borg, GR Hunter, H Hosoda, HS Callahan, J Laforgia, J Laforgia, JA Babraj, JA King, JC Richards, JE Blundell, JI Medbø, JM Hagberg, JV Durnin, KA Burgomaster, KA Burgomaster, Kevin Deighton, KG Murphy, KN Frayn, LJ Whyte, M Rakobowchuk, M Tschöp, MD Mifflin, NA King, NA King, P Imbeault, R Bahr, Ruth Barry, SG Trost, SY Ueda, TA Hagobian   +41 more
core   +1 more source

First‐in‐Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN‐3143, a Novel Inhibitor of Mono‐Adenosine Diphosphate Ribosyltransferase‐PARP14

Clinical Pharmacology in Drug Development, EarlyView.
Abstract RBN‐3143 is an inhibitor of PARP14 in development for inflammatory diseases. Multiple assessments were conducted to evaluate the clinical pharmacology properties of RBN‐3134. A randomized, double‐blind, placebo‐controlled study assigned healthy volunteers (HVs) to single ascending doses (SADs) (25‐1000 mg) or multiple ascending doses (MADs ...
Thomas M. Polasek, Alexandra Cole, Viviana Bozón, Erika Manyak, Jonathan Novak, Barbara Yang, Briohny A. Johnston, Sudha Parasuraman, Kushal J. Paneliya, Virna Schuck   +9 more
wiley   +1 more source

Effect of Cytochrome P450 3A Inhibition and Induction by Itraconazole and Rifampin on Tazemetostat Pharmacokinetics in Patients With Advanced Malignancies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This study (NCT04537715) investigated itraconazole (strong cytochrome P450 [CYP] 3A inhibitor) and rifampin (strong CYP3A inducer) on tazemetostat pharmacokinetics. In Part 1, patients received tazemetostat 400 mg orally on Days 1, 15, and 36, and 400 mg twice daily on Days 3‐14 and Days 21‐35.
Yingxue Chen, Renli Teng, Attila Szanto, Apoorva Kapopara, Rajat Bannerji, Julien Ogier, Devalingam Mahalingam   +6 more
wiley   +1 more source

Appetite regulation: new opportunities for weight control [PDF]

, 2000
David Morgan
openalex   +1 more source

Appetite and gut hormone responses to moderate-intensity continuous exercise versus high-intensity interval exercise, in normoxic and hypoxic conditions. [PDF]

, 2015
This study investigated the effects of continuous moderate-intensity exercise (MIE) and high-intensity interval exercise (HIIE) in combination with short exposure to hypoxia on appetite and plasma concentrations of acylated ghrelin, peptide YY (PYY), and
Alkahtani, Ariyasu, Banks, Bartlett, Bigaard, Borg, Bryna C. Chrismas, Burns, Canoy, Catenacci, Catherine J. Kerr, Charlot, Chelikani, Daniel P. Bailey, David J. Stensel, Debevec, Deighton, Deighton, Deighton, Dill, Evero, Faul, Flint, Gibala, Goodyear, Grafen, Hommel, Hosoda, Jessica A. Douglas, Kalson, Kayser, Kelly, Kessler, Kevin Deighton, King, Koliaki, Lee Taylor, Lindsey R. Smith, Loshbaugh, Martins, Mifflin, Morton, Murphy, Nakagawa, Ross, Saad, Schaller, Schubert, Sim, Snyder, Stubbs, Tsilchorozidou, Ueda, Ueda, Vandenbogaerde, Wasse, West, Westerterp-Plantenga, Williams, Wolff   +59 more
core   +3 more sources

Irregular meal-pattern effects on energy expenditure, metabolism, and appetite regulation: a randomized controlled trial in healthy normal-weight women.

American Journal of Clinical Nutrition, 2016
BACKGROUND Obesity is increasing in parallel with greater all-day food availability. The latter may promote meal irregularity, dysregulation of the energy balance, and poor metabolic health.
M. Alhussain, I. Macdonald, Moira A. Taylor   +2 more
semanticscholar   +1 more source

Dose–response effect of a whey protein preload on within-day energy intake in lean subjects [PDF]

, 2010
The effect of consuming different amounts of whey protein on appetite and energy intake was investigated in two separate studies using randomised, crossover designs.
Emma J. Stevenson, Henderson, Ian A. Macdonald, Kissileff, Moira A. Taylor, Nerys M. Astbury, Penelope Morris, Schofield, Stubbs   +8 more
core   +1 more source

A Randomized Thorough QT Trial Using Concentration‐QT Analysis to Evaluate the Effects of Centanafadine on Cardiac Repolarization

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Centanafadine is a norepinephrine/dopamine/serotonin reuptake inhibitor in development for treatment of attention‐deficit/hyperactivity disorder. This double‐blind, placebo‐ and moxifloxacin‐controlled, 3‐period crossover trial evaluated the effects of centanafadine (EB‐1020) and its metabolite (EB‐10601) on cardiac repolarization in 30 ...
Osman S. Turkoglu, Xiaofeng Wang, Jennifer Repella‐Gordon, Susan E. Shoaf   +3 more
wiley   +1 more source