Results 71 to 80 of about 2,944,585 (366)

A Hypoxia‐Triggered Bioreduction of Hydrophilic Type I Photosensitizer for Switchable In Vivo Photoacoustic Imaging and High‐Specificity Cancer Phototherapy

open access: yesAngewandte Chemie, EarlyView.
A hydrophilic type I phototherapeutic agent (NanoPcN8O) was developed which selectively responded to hypoxic tumor microenvironments and switched on type I photodynamic and photothermal effects as well as a photoacoustic signal for activatable photoacoustic imaging and tumor phototherapy.
Yuan‐Yuan Zhao   +6 more
wiley   +2 more sources

Targeting the Gut in Obesity: Signals from the Inner Surface

open access: yesMetabolites, 2022
Obesity is caused by prolonged energy surplus. Current anti-obesity medications are mostly centralized around the energy input part of the energy balance equation by increasing satiety and reducing appetite.
Natalia Petersen   +6 more
doaj   +1 more source

Hypoxia-Related Hormonal Appetite Modulation in Humans during Rest and Exercise: Mini Review

open access: yesFrontiers in Physiology, 2017
Obesity is associated with numerous chronic ailments and represents one of the major health and economic issues in the modernized societies. Accordingly, there is an obvious need for novel treatment approaches.
Tadej Debevec
doaj   +1 more source

Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior

open access: yesBiomolecules, 2022
Spexin (SPX) is a recently identified neuropeptide that is believed to play an important role in the regulation of energy homeostasis. Here, we describe a mediating function of SPX in hypothalamic leptin action.
Bora Jeong   +8 more
doaj   +1 more source

Effect of feeding stimulants on growth performance, feed intake and appetite regulation of mandarin fish,Siniperca chuatsi

open access: yesAquaculture Research, 2019
Mandarin fish is a typical carnivorous fish, it can accept artificial diet after domestication, which is significantly essential to optimize its artificial diet. Nevertheless, only few studies were conducted on artificial diet of mandarin fish. Therefore,
Liao Li   +5 more
semanticscholar   +1 more source

Early causes of child obesity and implications for prevention [PDF]

open access: yes, 2007
Child obesity is becoming a serious public health concern, and major research effort is being devoted both to understand its aetiology and to improve the effectiveness of prevention strategies.
Cole, T.J.
core  

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

open access: yes, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S.   +3 more
core   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Metabolic and endocrine responses to hypoxic exposure

open access: yesJournal of Physical Fitness and Sports Medicine, 2013
A growing body of evidence suggests that exposure to hypoxic conditions during rest and exercise may be beneficial for the prevention of metabolic syndrome.
Kazushige Goto
doaj   +1 more source

Functional Characterization of Melanocortin-3 Receptor in a Hibernating Cavefish Onychostoma macrolepis

open access: yesAnimals, 2021
Melanocortin-3 receptor (MC3R) plays an important role in the energy homeostasis of animals under different nutritional conditions. Onychostoma macrolepis is a hibernating cavefish found in the northern part of the Yangtze River, and its adaptation to a ...
Lian Wu   +8 more
doaj   +1 more source

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