Results 41 to 50 of about 10,186 (263)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Approximating Polynomials for Functions of Weighted Smirnov-Orlicz Spaces

Journal of Function Spaces and Applications, 2012
Let 𝐺0 and 𝐺∞ be, respectively, bounded and unbounded components of a plane curve Γ satisfying Dini's smoothness condition. In addition to partial sum of Faber series of 𝑓 belonging to weighted Smirnov-Orlicz space 𝐸𝑀,𝜔 (𝐺0), we prove that interpolating ...
Ramazan Akgün
doaj   +1 more source

Rational approximation to e and to related functions

Journal of Approximation Theory, 1979
AbstractAccording to a well-known result of S. N. Bernstein, ex can be approximated uniformly on [−1, 1] by polynomials of degree ⩽n with an error of the order [2n(n + 1)!]−1. In this note it is shown that the smallest (uniform norm) error in approximating ex by reciprocals of polynomials of degree ⩽n is also of the order [2n(n + 1)!]−1.
Newman, D.J, Reddy, A.R
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A priori bounds for truncation error of branched continued fraction expansions of Horn's hypergeometric functions $H_4$ and their ratios

Researches in Mathematics
The paper considers the extension of analytic functions by a special family of functions — branched continued fractions. The truncation error bounds for branched continue fraction expansions of the Horn's hypergeometric functions $H_4$ and their ratios ...
R.I. Dmytryshyn, C. Cesarano, M. Dmytryshyn, I.-A.V. Lutsiv   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On the analytical continuation of the ratio $H_4(\alpha,\delta+1;\gamma,\delta;-\mathbf{z})/H_4(\alpha,\delta+2;\gamma,\delta+1;-\mathbf{z})$

Researches in Mathematics
The paper considers the problem of analytical continuation of special functions by branched continued fractions. These representations play an important role in approximating of special functions that arise in various applied problems. By improving the
R. Dmytryshyn, C. Cesarano, I.-A. Lutsiv
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On Lp-approximation by Mütz rational functions(Müntz有理函数的加权Lp逼近)

Zhejiang Daxue xuebao. Lixue ban, 2017
考察了加Jacobi权w(x)=xα(1-x)α(α≥0)的Lp空间中Müntz有理函数的逼近问题.利用K-泛函与加权光滑模的等价性给出了逼近阶的估计以及Ditzian-Totik型定理.所得结果将已有文献中的相应结论推广到了加权情形.
WANGJunxia(王军霞), LIGuocheng(李国成)   +1 more
doaj   +1 more source