Results 61 to 70 of about 11,753 (303)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

On the Domain of Analytical Continuation of the Ratios of Generalized Hypergeometric Functions ₃F₂

Axioms
The paper considers the problem of the analytical extension of the ratios of generalized hypergeometric functions F23 A new domain of analytic continuation for these ratios under certain conditions to parameters is established.
Roman Dmytryshyn, Marta Dmytryshyn, Sofiia Hladun   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Rational approximation to e and to related functions

Journal of Approximation Theory, 1979
AbstractAccording to a well-known result of S. N. Bernstein, ex can be approximated uniformly on [−1, 1] by polynomials of degree ⩽n with an error of the order [2n(n + 1)!]−1. In this note it is shown that the smallest (uniform norm) error in approximating ex by reciprocals of polynomials of degree ⩽n is also of the order [2n(n + 1)!]−1.
Newman, D.J, Reddy, A.R
openaire   +1 more source

Piecewise rational approximation to continuous functions with characteristic singularities

, 1998
Let Hvp[a,b] be the class of continuous functions in the interval [a,b], which admit analytic continuation to Hp in the subintervals of a v-subdivition of [a,b].
Illán, J.
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Approximating Polynomials for Functions of Weighted Smirnov-Orlicz Spaces

Journal of Function Spaces and Applications, 2012
Let 𝐺0 and 𝐺∞ be, respectively, bounded and unbounded components of a plane curve Γ satisfying Dini's smoothness condition. In addition to partial sum of Faber series of 𝑓 belonging to weighted Smirnov-Orlicz space 𝐸𝑀,𝜔 (𝐺0), we prove that interpolating ...
Ramazan Akgün
doaj   +1 more source

An Approximate Transfer Function Model for a Double-Pipe Counter-Flow Heat Exchanger

Energies, 2021
The transfer functions G(s) for different types of heat exchangers obtained from their partial differential equations usually contain some irrational components which reflect quite well their spatio-temporal dynamic properties. However, such a relatively
Krzysztof Bartecki
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chebyshev approximation by rational expression functions of two variables

, 2019
Запропоновано метод побудови чебишовського наближення раціональним виразом для функцій двох змінних. Ідея методу ґрунтується на побудові граничного середньостепеневого наближення у нормі простору Lⁿ при n →∞.
Монцібович, Б.Р., Пізюр, Я.В., Малачівський, П.С., Малачівський, Р.П.   +3 more
core   +1 more source