Results 51 to 60 of about 57,073,214 (327)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Novel Computer Software for Interpolation and Approximation of Ravine and Stiff Digital Dependencies Using Root-Polynomoal and Root-Fractional-Rational Functions

Proceedings of the International Conference on Applied Innovations in IT
The article considers the possibilities of solving interpolation and approximation problems using special types of functions, such as root polynomials and root fractional rational, and provides relevant examples.
Igor Melnyk, Mykhailo Skrypka, Alina Pochynok, Olga Demyanchenko   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Approximation of conic sections by weighted Lupaş post-quantum Bézier curves

Demonstratio Mathematica, 2022
This paper deals with weighted Lupaş post-quantum Bernstein blending functions and Bézier curves constructed with the help of bases via (p,q)\left(p,q)-integers. These blending functions form normalized totally positive bases.
Khan Asif, Iliyas Mohammad, Khan Khalid, Mursaleen Mohammad   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Approximation by rational functions in Morrey-Smirnov classes

Kuwait Journal of Science, 2018
In this article, we investigate the direct problem of approximation theory in Morrey-Smirnov classes of analytic functions, defined on a doubly-connected domain bounded by two sufficiently smooth curves.
Mohammad Ali, Suliman Mahmoud, Ahmed kinj   +2 more
doaj  

Design of Multi-Dimensional Recursive Systems through Pad'e Type Rational Approximation

Nonlinear Analysis, 2002
The results obtained in classical 1-D rational approximation are extended in this paper to rational approximation of M-D functions. A full analog of classical Montessus de Ballore theorem for the convergence of the rows of Pad´e’s tables is obtained.
Valeri V. Vavilov, Mikhail K. Tchobanou, Peter M. Tchobanou   +2 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

On Analytical Extension of Generalized Hypergeometric Function ₃F₂

Axioms
The paper considers the generalized hypergeometric function F23, which is important in various fields of mathematics, physics, and economics. The method is used, according to which the domains of the analytical continuation of the special functions are ...
Roman Dmytryshyn, Volodymyra Oleksyn
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source