Results 71 to 80 of about 8,326 (241)

Assessing the impact of aprepitant and ondansetron on postoperative nausea and vomiting in orthognathic surgeries: a randomized controlled trial

BMC Anesthesiology, 2023
Background Postoperative nausea and vomiting (PONV) is a common side effect associated with general anesthesia. Both ondansetron and aprepitant been effectively used to prevent PONV.
Mostafa Alam, Alireza Shakeri, Ardeshir Khorsand, Karim Nasseri, Sadaf Nasseri   +4 more
doaj   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Cost-effectiveness of an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting in patients with breast cancer in the UK

Cancer Management and Research, 2013
Samantha Humphreys,1 James Pellissier,2 Alison Jones3 1Market Access Department, Merck Sharp and Dohme Ltd, Hoddesdon, Hertfordshire, UK; 2Health Economic Statistics, Merck Research Laboratories, Upper Gwynedd, PA, USA; 3Department of Medical Oncology ...
Humphreys S, Pellissier J, Jones A
doaj  

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects

Drug Design, Development and Therapy, 2020
Meng-Jie Yang, Hong-Rong Xu, Hui Li, Wei-Li Chen, Fei Yuan, Xue-Ning Li Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Xue-Ning LiDepartment of Clinical Pharmacology ...
Yang MJ, Xu HR, Li H, Chen WL, Yuan F, Li XN   +5 more
doaj  

Two Cases of Fatal Encephalopathy Related to Ifosfamide: An Adverse Role of Aprepitant

Case Reports in Oncology, 2014
Ifosfamide is used in the treatment of sarcomas and other tumors. It sometimes provokes encephalopathy, which is a serious complication even if it is usually reversible within 48-72 h after drug cessation.
Alice Séjourné, Sabine Noal, Mathieu Boone, Céline Bihan, Marion Sassier, Michel Andrejak, Bruno Chauffert   +6 more
doaj   +1 more source

Exploring Clinical Similarities and Distinctions Between Gastroparesis and Functional Dyspepsia: A Propensity‐Matched Cohort Study

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
Despite overlapping upper gastrointestinal symptoms, gastroparesis and functional dyspepsia demonstrate distinct population‐level symptom patterns, with nausea, vomiting, and bloating predominating in gastroparesis and epigastric pain in functional dyspepsia.
Sameer Rao, Vraj Shah, Rohan Karkra, Manas Gunani, Ritik Mahaveer Goyal, Ahmed Al‐Khazraji, Kaveh Hajifathalian, Amanda A. Rupert   +7 more
wiley   +1 more source

The effect of aprepitant, a neurokinin-1 receptor antagonist, on epileptiform activity in the penicillin model of epilepsy

Medicine Science
Substance P (SP) is a peptide neurotransmitter that plays a role in pain transmission, stress, inflammation, and emesis through neurokinin-1 receptor (NK-1R).
Selma Cirrik, Eli̇f Dogan, Ali̇ Aslan, Ni̇yazi̇ Tasci   +3 more
doaj   +1 more source

Pre-therapy mRNA expression of TNF is associated with regimen-related gastrointestinal toxicity in patients with esophageal cancer: a pilot study [PDF]

, 2015
Author version made available following 12 month embargo from date of publication (27 March 2015) in accordance with publisher copyright policy.Purpose Esophageal cancer has a high mortality rate, and its multimodality treatment is often associated ...
Bowen, Joanne M, Game, Philip A, Hussey, Damian James, Irvine, Tanya S, Karapetis, Christos Stelios, Keefe, Dorothy M K, Kristaly, Kerry, Smith, Lorelle T, Tan, Thean Hsiang, Thompson, Sarah K, Tsykin, Anna, Watson, David Ian, White, Ian   +12 more
core   +1 more source

Ruxolitinib and Hydroxycarbamide Are the Most Efficient Drugs to Reduce Aquagenic Pruritus Intensity in a Real‐Word Cohort of Patients With Myeloproliferative Neoplasms

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Aquagenic pruritus (AP) is a common and distressing symptom in myeloproliferative neoplasm (MPN) patients. Methods This study assessed cytoreductive therapy effectiveness using data from 489 patients in the OBENE Observatory (NCT02897297). AP severity was tracked regularly after diagnosis.
Christelle Le Gall‐Ianotto, Lanig Civi, Brigitte Pan‐Petesch, Laura Herbreteau, Laetitia Rio, Wayne‐Corentin Lambert, Laurent Misery, Eric Lippert, Jean‐Christophe Ianotto   +8 more
wiley   +1 more source