Results 101 to 110 of about 113,904,810 (178)

Effects of Selective and Mixed-Action Kappa and Delta Opioid Receptor Agonists on Pain-Related Behavioral Depression in Mice

Molecules
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produce ...
S. Stevens Negus, Celsey M. St. Onge, Young K. Lee, Mengchu Li, Kenner C. Rice, Yan Zhang   +5 more
doaj   +1 more source

Human acute myeloid leukemia cells express Neurokinin-1 receptor, which is involved in the antileukemic effect of Neurokinin-1 receptor antagonists

, 2018
The substance P/neurokinin-1 receptor system has been implicated in tumor cell proliferation. Neurokinin-1 receptor has been identified in different solid tumors but not frequently in hematopoietic malignant cells.
Muñoz Sáez, Miguel, Molinos-Quintana, A., Trujillo-Hacha, P., Piruat, José I., Pérez-Simón, José A., García-Guerrero, Estefanía, Bejarano-García, José A., A. Molinos-Quintana, J. A. Bejarano-García, P. Trujillo-Hacha, J. I. Piruat, J. A. Pérez-Simón, Miguel Muñoz, E. García-Guerrero   +13 more
core   +1 more source

Aprepitant in Adolescent Patients for Prevention of Chemotherapy-Induced Nausea and Vomiting: A Randomized, Double-Blind, Placebo-Controlled Study of Efficacy and Tolerability

, 2009
Background. the neurokinin-1 receptor antagonist aprepitant, plus a 5HT3 antagonist and corticosteroid is well-tolerated and effective in preventing chemotherapy-induced nausea and vomiting in adults but has not been formally assessed in adolescents ...
Valentine, Jack, Evans, Judith K., Chua, Vickey, Adolescent Aprepitant Canc Study G, Gore, Lia, Carides, Alexandra D., Oxenius, Bettina, Hemenway, Molly, Taylor, Arlene, Schissel, Debra, Petrilli, Antonio [UNIFESP], DeVandry, Suzanne, Chawla, Sant   +12 more
core   +1 more source

Recent advances in treatment of prurigo nodularis

Dermatologica Sinica
Prurigo nodularis is a chronic skin condition which has significant negative impacts on the psychosocial function and quality of life of affected patients.
Chieh-Hsun Chen, Stephen Chu-Sung Hu
doaj   +1 more source

Aprepitant Sensitizes Acute Myeloid Leukemia Cells to the Cytotoxic Effects of Cytosine Arabinoside in vitro and in vivo

Drug Design, Development and Therapy, 2020
Hongzhang Wu,1,* Xurui Cheng,1,* Feiyan Huang,2 Gang Shao,3 Yueming Meng,1 Lingfei Wang,3 Tao Wang,1 Xiaoyuan Jia,1 Tianxin Yang,4 Xi Wang,3 Caiyun Fu1 1Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences ...
Wu H, Cheng X, Huang F, Shao G, Meng Y, Wang L, Wang T, Jia X, Yang T, Wang X, Fu C   +10 more
doaj  

Will elinzanetant, a neurokinin receptor antagonist, have a role in the treatment of hot flashes?

Introduction The use of hormonal treatment for the vasomotor symptoms (VSM) associated with the menopause is back in favor, as the adverse effects reported in the early 2000s have been dispelled.
Doggrell, Sheila A
core   +1 more source

Aprepitant exposure and long-term prognosis in breast cancer: a propensity-score-matched cohort study

European Journal of Medical Research
Background Whether the neurokinin-1 receptor (TACR1) antagonist aprepitant confers oncologic benefit beyond antiemesis remains uncertain. We evaluated the association between aprepitant exposure during adjuvant chemotherapy and long-term outcomes in ...
Limin Pan, Zhiyuan Zhang, Wanyue Li, Feng Lv, Yuanxiang Lu, Yimin Liu   +5 more
doaj   +1 more source

The role of substance P/neurokinin 1 receptor in the pathogenesis of esophageal squamous cell carcinoma through constitutively active PI3K/Akt/NF-κB signal transduction pathways

, 2020
One of the most prevalent malignancies is esophageal squamous cell carcinoma (ESCC), which is associated with high morbidity and mortality. Substance P (SP), as one of the peptides released from sensory nerves, causes the enhancement of cellular ...
Asadi, J., Hashemy, S.I., Zahedi Avval, F., Afshari, A.R., Javid, H.   +4 more
core  

Association of co-administration of neurokinin-1 receptor antagonists and dexamethasone with new-onset diabetes in patients receiving chemotherapy: a retrospective cross-sectional study using health claims database in Japan. [PDF]

Support Care Cancer
Ozawa Y, Suzuki S, Koinuma T, Yokokawa T, Ichimura T, Suzuki K, Hori Y, Imai S.   +7 more
europepmc   +1 more source

Refractory nausea in an 86-year-old patient after surgery. [PDF]

CMAJ
Bhattacharjee A, Gruber A, MacMillan TE, Shah R.   +3 more
europepmc   +1 more source