Up-Regulated Expression of Substance P in CD8+ T Cells and NK1R on Monocytes of Atopic Dermatitis [PDF]
Journal of Translational Medicine, 2017 Background Large numbers of CD8+ T cells were observed in atopic dermatitis (AD) skin, and monocytes from AD patients showed increased prostaglandin E2 production. However, little is known about the expression of substance P (SP) and its receptor NK1R in
Junling Wang, Hua Xie, Huiyun Zhang
exaly +7 more sources
Carbohydrate-Based NK1R Antagonists With Broad-Spectrum Anticancer Activity [PDF]
Journal of Medicinal Chemistry, 2021 NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R antagonists and their evaluation as anticancer agents against a wide range of cancer cells.
José Manuel Calderón-Montaño +2 more
exaly +6 more sources
Potential Therapeutic Effect of NK1R Antagonist in Diabetic Non-Healing Wound and Depression
Frontiers in Endocrinology, 2023 Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging.
Mingyu Li +6 more
exaly +5 more sources
The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein
Neurology Research International, 2021 Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani +4 more
doaj +4 more sources
The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells [PDF]
Biochemistry Research International, 2021 Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating ...
Faranak Korfi +3 more
doaj +4 more sources
Proteomic and Phosphoproteomic Analysis Reveals That Neurokinin-1 Receptor (NK1R) Blockade With Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists [PDF]
Medicines (Basel, Switzerland), 2019 Background: Epidermal growth factor receptor (EGFR) inhibitors can cause serious cutaneous toxicities, including pruritus and papulopustular acneiform skin eruptions. Increasingly, the neurokinin-1 receptor (NK1R) antagonist aprepitant is being utilized as an anti-pruritic agent in the treatment of EGFR-inhibitor induced pruritus.
Emily Boozalis +2 more
exaly +4 more sources
Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress [PDF]
Gastroenterology, 2009 Chronic psychological stress is associated with visceral hyperalgesia and increased expression of spinal NK1 receptors (NK1Rs). We aimed to identify the role of spinal microglia in this process.Male Wistar rats were exposed to water avoidance (WA) or sham stress 1 hour each day for 10 days and given daily injections of minocycline, the p38 inhibitor ...
Camilla I Svensson +2 more
exaly +3 more sources
European Journal of Histochemistry, 2023 Neurokinin-1 receptor (NK1R) belongs to tachykinin receptor family. Recent studies have suggested that NK1R was upregulated in cancer tissues including breast cancer, glioma and melanoma.
Liyun Guan +5 more
doaj +1 more source
Cell Death and Disease, 2023 The widespread application of antiandrogen therapies has aroused a significant increase in the incidence of NEPC, a lethal form of the disease lacking efficient clinical treatments.
Xiao-Wei Zhang +12 more
doaj +1 more source
Performance deficits of NK1 receptor knockout mice in the 5-choice serial reaction-time task: effects of d-amphetamine, stress and time of day. [PDF]
PLoS ONE, 2011 BackgroundThe neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD).
Ting Carrie Yan +8 more
doaj +1 more source