Results 21 to 30 of about 3,155 (190)

Exploring neurokinin-1 receptor antagonism for depression with structurally differentiated inhibitors [PDF]

Experimental and Molecular Medicine
The neurokinin-1 receptor (NK1R) has been investigated as a potential target for major depressive disorder owing to its role in stress regulation and neuroinflammation.
Hyeijung Yoo, Kyung-Jun Boo, Lan Phuong Nguyen, Jong-Ik Hwang, Cheol Soon Lee, Soo Hyun Yang, Se Jin Jeon, Hong-Rae Kim, Hyun Kim   +8 more
doaj   +2 more sources

Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone‐Producing Adenomas [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Aldosterone‐producing adenoma (APA) is a major cause of primary aldosteronism, the most frequent form of secondary hypertension. Although somatic mutations in ion channels within APA have been shown to activate Ca2+ signaling and drive ...
Antoine‐Guy Lopez, Céline Duparc, Sylvie Renouf, Margot D’Agostino, Kelly De Sousa, Laurence Amar, Guillaume Defortescu, Gilles Manceau, Jean‐Christophe Sabourin, Fabio Luiz Fernandes‐Rosa, Maria‐Christina Zennaro, Tchao Meatchi, Gaël Nicolas, Estelle Louiset, Hervé Lefebvre   +14 more
doaj   +2 more sources

Comparative Ion Channel Transcriptomes of NK1R and Somatostatin Neurons in the PreBötzinger Complex of the Ventrolateral Medulla [PDF]

Molecular Neurobiology
Abstract The preBötzinger Complex is among the few neural circuits where selective elimination of defined neuronal subpopulation is sufficient to destabilize a core autonomic function and can fatally impair breathing. Within this circuitry, neurons expressing the neurokinin-1 receptor ( Tacr1/NK1R
Bhagavan, Hemalatha, Wei, Aguan D., Oliveira, Luiz M., Ramirez, Jan-Marino   +3 more
openaire   +4 more sources

NaV1.7 mRNA and Protein Expression in Resident Neurons of the Human Spinal Dorsal Horn [PDF]

Journal of Comparative Neurology, Volume 534, Issue 5, May 2026.
We identified Nav1.7 mRNA and protein in human spinal cord neurons, a subset of which co‐expressed putative projection neuron markers, TACR1 and GPR83. These neurons relay nociceptive signals from the periphery to the brain. While Nav1.7 loss‐of‐function mutations cause congenital insensitivity to pain, traditionally linked to sensory neurons, our ...
Stephanie Shiers, Nwasinachi A. Ezeji, Carla Lima‐Truax, Jeffrey L. Krajewski, Geoffrey Funk, Anna Cervantes, Peter Horton, Gregory Dussor, Stephanie Hennen, Theodore J. Price   +9 more
wiley   +2 more sources

Neuro-immune-epithelial pathways involving substance P may contribute to mucosal pathology in gastro-oesophageal reflux disease [PDF]

Frontiers in Immunology
IntroductionSubstance P (SP) is contained in nerve fibres innervating the oesophageal mucosa and is released into the mucosa during oesophageal acid perfusion. However, the downstream effects of this peripheral SP are not known.
Tom Leech, Philip Woodland, Madusha Peiris   +2 more
doaj   +2 more sources

Human Substance P Interactions with G Protein-Coupled Receptor NK1R Observed by NMR in Solution [PDF]

Journal of the American Chemical Society
Neurokinin 1 receptor (NK1R) is a class A G protein-coupled receptor (GPCR) that interacts with the endogenous undecapeptide agonist Substance P (SP) to activate its role in key physiological processes such as nausea, inflammation, and neurological disorders.
Haoyi Ge, Lingyun Yang, Changran Chen, Yuxin Xu, Dongsheng Liu, Kurt Wüthrich   +5 more
openaire   +3 more sources

Evaluation of Serum Substance P Level and Tissue Distribution of NK-1 Receptor in Papillary Thyroid Cancer [PDF]

Middle East Journal of Cancer, 2021
Background: Papillary thyroid carcinoma (PTC) is the most prevalent malignancy of the endocrine system. This study was aimed at evaluating the serum substance P (SP) levels, the tissue distribution of Neurokinin-1 receptors (NK1-R), and their possible ...
Mahdi Asadi, Seyedeh Motahareh Mirdoosti, Saeed Majidi, Nadia Boroumand, Amir-Hossein Jafarian, Seyed Isaac Hashemy   +5 more
doaj   +1 more source

Die Rolle des NK1R unter dem Einfluss von Fluid Flow Shear Stress in murinen Osteozyten [PDF]

, 2022
In Chondrozyten und auch in Tenozyten zeigte sich, dass der NK1R als zentraler Mechanorezeptor fungiert und unter anderem auch wesentlich die endogene Produktion von SP und die Zellproliferation beeinflussen kann.
Kalhammer, Judith
core   +1 more source

Expression of substance P, neurokinin 1 receptor, Ki-67 and pyruvate kinase M2 in hormone receptor negative breast cancer and evaluation of impact on overall survival

BMC Cancer, 2023
Background Chronic inflammation is a hallmark of cancer, and it can be stimulated by many factors. Substance P (SP), through binding to neurokinin 1 receptor (NK1R), and pyruvate kinase M2 (PKM2) play critical roles in cancer development and progression ...
Maha S. Al-Keilani, Roba Bdeir, Rana I. Elstaty, Mohammad A. Alqudah   +3 more
doaj   +1 more source

Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR

Cell Death and Disease, 2022
Despite the great advances in target therapy, lung cancer remains the top cause of cancer-related death worldwide. G protein-coupled receptor neurokinin-1 (NK1R) is shown to play multiple roles in various cancers; however, the pathological roles and ...
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou   +9 more
doaj   +1 more source