Results 41 to 50 of about 3,155 (190)

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Cell Reports, 2020
Summary: Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs).
Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina   +12 more
doaj   +1 more source

Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner. [PDF]

PLoS ONE, 2011
U373MG astrocytoma cells endogenously express the full-length neurokinin 1 receptor (NK1R). Substance P (SP), the natural ligand for NK1R, triggers rapid and transient membrane blebbing and we report that these morphological changes have different ...
John Meshki, Steven D Douglas, Mingyue Hu, Susan E Leeman, Florin Tuluc   +4 more
doaj   +1 more source

Table_2_Potential therapeutic effect of NK1R antagonist in diabetic non-healing wound and depression.docx

, 2023
Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging.
Shunuo Zhang (11894687), Yixin Zhang (173038), Hao Ma (114667), Liang Ding (333279), Yuan Peng (714023), Peiru Min (11894690), Mingyu Li (482173)   +6 more
core   +1 more source

Substance P enhances the local activation of NK1R-expressing c-kit+ cardiac progenitor cells in right atrium of ischemia/reperfusion-injured heart

BMC Molecular and Cell Biology, 2020
Background Localization of neurokinin 1 receptor (NK1R), the endogenous receptor for neuropeptide substance P (SP), has already been described for the right atrium (RA) of the heart.
Yun-Mi Jeong, Xian Wu Cheng, Kyung Hye Lee, Sora Lee, Haneul Cho, Weon Kim   +5 more
doaj   +1 more source

Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships

, 2022
Locoregionally administered, NK1 receptor (NK1R) targeted radionuclide therapy is a promising strategy for the treatment of glioblastoma multiforme. So far, the radiopharmaceuticals used in this approach have been based on the endogenous agonist of NK1R,
Katarzyna Kosińska, Ewa Gniazdowska, Paweł K. Halik, Joanna Matalińska, Przemysław Koźmiński, Piotr F. J. Lipiński, Aleksandra Misicka   +6 more
core   +1 more source

Diffusion curves of lipid vesicles, NK1R and NK1R-NLP complexes.

, 2012
The lipids and NK1R were labeled by Texas Red and GFP respectively. The cross correlation of Texas Red and GFP represents the interaction between lipids and NK1R, indicating the formation of NK1R-associated NLPs.
John Voss (131458), Matthew A. Coleman (131460), Jitka Petrlova (131452), Tingjuan Gao (131450), Thomas Huser (131454), Wei He (131453), Wieslaw Kudlick (131456)   +6 more
core   +1 more source

P2 microparticles contain NK1R.

, 2013
HEK293 cells were transfected with a plasmid encoding the NK1R-GFP fusion protein. HEK293-NK1R-GFP and HEK293-NK1R cells were stimulated with SP to generate microparticles, then analyzed by flow cytometry.
John Meshki (36999), Steven D. Douglas (204098), Panpan Chen (307628), Florin Tuluc (36996)   +3 more
core   +1 more source

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Acta Dermato-Venereologica, 2017
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients ...
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz   +7 more
doaj   +1 more source

Saturation binding curve of NK1R-NLPs to FAM-SP.

, 2012
[NK1R-NLPs] is the concentration of free NK1R-NLPs at equilibrium and was calculated from the subtraction of the amount of NK1R-NLPs bound with FAM-SP from the total amount of NK1R-NLPs added.
John Voss (131458), Matthew A. Coleman (131460), Jitka Petrlova (131452), Tingjuan Gao (131450), Thomas Huser (131454), Wei He (131453), Wieslaw Kudlick (131456)   +6 more
core   +1 more source

Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R–/– mice

European Journal of Neuroscience, 2007
AbstractThe behaviour of neurokinin‐1‐receptor gene knockout (NK1R–/–) mice, which lack functional, substance P‐preferring receptors, resembles that of NK1R+/+ mice treated with an antidepressant. Because all antidepressants increase central monoamine transmission, we have investigated whether noradrenergic transmission is increased in NK1R–/– mice and,
Amy S, Fisher, R John, Stewart, Ting, Yan, Stephen P, Hunt, S Clare, Stanford   +4 more
openaire   +5 more sources