Results 61 to 70 of about 3,155 (190)
Diffusion curves of FAM-SP after binding with different amounts of NK1R-NLPs.
, 2012 Sample a to e represent 80 µL FAM-SP binding with 0.5, 4, 8, 12, 20 µL NK1R-NLP complexes respectively. Sample f to h represent 20, 10, 4, 2 µL FAM-SP binding with 10 µL NK1R-NLPs complexes respectively.
John Voss (131458) +6 more
core +1 more source
Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli +12 more
wiley +1 more source
Molecular Pain, 2008 NMDA receptors are important elements in pain signaling in the spinal cord dorsal horn. They are heterotetramers typically composed of two NR1 and two of four NR2 subunits: NR2A-2D.
MacDermott Amy B +2 more
doaj +1 more source
NK1r and sst2A in superficial dorsal horn.
, 2013 Confocal image showing a single optical section through part of laminae I and IIo, scanned to reveal NK1r (green) and sst2A (magenta). a: Two NK1r-immunoreactive cell bodies (arrows) are visible in lamina I, surrounded by a plexus of labelled dendrites ...
Andrew J. Todd (179384) +3 more
core +1 more source
Pharmacology Research & Perspectives, 2022 The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK1R). More recently, it has also been shown to activate the Mas‐related G protein‐coupled receptor X2 (MRGPRX2) receptor on mast cells (MCs ...
Lin Hsin +7 more
doaj +1 more source
Cells, 2023 Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease that primarily attacks the lacrimal and salivary glands, resulting in impaired secretory function characterized by xerostomia and xerophthalmia.
Pamela Rosso +11 more
doaj +1 more source
Pathogenic role of the SP/ NK1R system in GBM cells through inhibiting the thioredoxin system.
Iranian journal of basic medical sciences, 2021 Glioblastoma multiforme (GBM), a highly aggressive Grade IV brain tumor, is a significant public health issue due to its poor prognosis and incurability. Neuropeptide substance P (SP) plays a critical role in GBM tumor growth and development via activation of neurokinin-1receptor (NK1R).
Ghahremani, Fatemeh +5 more
openaire +3 more sources
Asian Journal of Organic Chemistry, Volume 15, Issue 10, October 2026.Reducing aryl nitro groups provides DNA‐linked anilines for use in benzimidazole synthesis and other scaffold‐forming reactions during the construction of DNA‐encoded libraries. This review examines transfer hydrogenation and Fe(II)‐, dithionite/viologen‐, diboron‐, and Pd‐based methods, focusing on how reaction efficiency, chemoselectivity, DNA ...
Yeongjoo Suh +3 more
wiley +1 more source
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors
Current Oncology, 2021 Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/
Julian Kolorz +13 more
doaj +1 more source