Results 71 to 80 of about 3,155 (190)

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

The neuropeptide substance P regulates aldosterone secretion in human adrenals

Nature Communications, 2020
Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept ...
Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre   +14 more
doaj   +1 more source

Association of genetic variants in CYP3A5, DRD2 and NK1R with opioid overdose

Chemico-Biological Interactions
In 2023, 3651 Ohioans died because of an opioid overdose. Of those opioid overdoses, 3579 (98%) of which were attributed to fentanyl. We evaluated the association between 180 candidate single nucleotide polymorphisms (SNPs) and self-reported, nonfatal opioid overdose history from a prospective sample of 1301 adult patients (≥18 years of age) seen in ...
Joshua Lambert, Dan Petrovitch, Katie P. Himes, Caroline E. Freiermuth, Robert S. Braun, Jennifer L. Brown, Jason J. Bischof, Michael S. Lyons, Brittany E. Punches, Andrew K. Littlefield, David F. Kisor, Jon E. Sprague   +11 more
openaire   +2 more sources

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

A lack of functional NK1 receptors explains most, but not all, abnormal behaviours of NK1R-/- mice [PDF]

, 2015
Mice lacking functional neurokinin-1 receptors (NK1R-/-) display abnormal behaviours seen in Attention Deficit Hyperactivity Disorder (hyperactivity, impulsivity and inattentiveness).
Peirson, SN, Stanford, SC, Pillidge, K, Tsai, YC, Porter, AJ, Hunt, SP, Dudley, JA, Brown, LA   +7 more
core  

Synthesis and Evaluation of a Novel ⁶⁴Cu- and ⁶⁷Ga-Labeled Neurokinin 1 Receptor Antagonist for in Vivo Targeting of NK1R-Positive Tumor Xenografts

, 2018
Neurokinin 1 receptor (NK1R) is expressed in gliomas and neuroendocrine malignancies and represents a promising target for molecular imaging and targeted radionuclide therapy.
Pooja Desai (3767557), Wolfgang A. Weber (226149), Philip S. Low (371711), Ananda Kumar Kanduluru (1317789), Afruja Ahad (4892290), Sean Carlin (248421), Hanwen Zhang (307516), Nidhi Tandon (4242541)   +7 more
core   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

Characterization of de novo synthesized GPCRs supported in nanolipoprotein discs. [PDF]

PLoS ONE, 2012
The protein family known as G-protein coupled receptors (GPCRs) comprises an important class of membrane-associated proteins, which remains a difficult family of proteins to characterize because their function requires a native-like lipid membrane ...
Tingjuan Gao, Jitka Petrlova, Wei He, Thomas Huser, Wieslaw Kudlick, John Voss, Matthew A Coleman   +6 more
doaj   +1 more source

Neurokinin-1 receptors in the nucleus accumbens shell influence sensitivity to social defeat stress and stress-induced alcohol consumption in male mice

Addiction Neuroscience
Chronic social defeat stress (SDS) is a widely employed preclinical model of depression involving repeated exposure to physical defeats using a resident-intruder model in male mice.
Matthew G. Solomon, Sadie E. Nennig, Mallory R. Cotton, Kimberly E. Whiting, Hannah D. Fulenwider, Jesse R. Schank   +5 more
doaj   +1 more source

When CO2 sensing fails: Protective effects of sex hormones and potential mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Breathing movements driven by the brainstem rhythmogenic neural networks rely on chemosensory inputs to produce a motor output that is homeostatically adjusted to the prevailing metabolic demand. The central CO2 chemoreflex is a critical component of respiratory neural circuitry, as defects in these sensors cause hypoventilation syndromes ...
Tara A. Janes, Silvia Cardani, Silvia Pagliardini   +2 more
wiley   +1 more source