Results 81 to 90 of about 3,155 (190)

Behavioural and neurochemical abnormalities in NK1 receptor knockout (NK1R-/-) mice: a novel rodent model of attention deficit/hyperactivity disorder [PDF]

, 2008
NK1 receptor knockout (NK1R-/-) mice (which lack functional substance P-preferring NK1 receptors) have: (i) impaired regulation of noradrenaline (NA) release by (-adrenoceptors, and (ii) disrupted response to the rewarding effect of the psychostimulant, /
Yan, T
core  

Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in Mice

, 2021
Hematoma clearance is an important therapeutic target to improve outcome following intracerebral hemorrhage (ICH). Recent studies showed that Neurokinin receptor-1 (NK1R) inhibition exerts protective effects in various neurological disease models, but ...
Travis, Zachary D., Huang, Lei, Lenahan, Cameron, Tang, Jiping, Lian, Lifei, Sherchan, Prativa, Cui, Yuhui, Xie, Shucai, Deng, Shuixiang, Li, Gaigai, Zhang, John H., Gong, Ye, Jin, Peng, Lei Huang, Yuhui Cui, Shucai Xie, Jiping Tang, Shuixiang Deng, Zachary D. Travis, Prativa Sherchan, Cameron Lenahan, Gaigai Li, John H. Zhang, Lifei Lian, Ye Gong, Peng Jin   +25 more
core   +1 more source

The Chemerin Receptor 23 Agonist, Chemerin, Attenuates Monosynaptic C-Fibre Input to Lamina I Neurokinin 1 Receptor Expressing Rat Spinal Cord Neurons in Inflammatory Pain

Molecular Pain, 2014
Background: Recent evidence has shown that the chemerin receptor 23 (ChemR23) represents a novel inflammatory pain target, whereby the ChemR23 agonists, resolvin E1 and chemerin, can inhibit inflammatory pain hypersensitivity, by a mechanism that ...
Allen C Dickie, Carole Torsney
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways

, 2021
Ethnopharmacological relevance: Chaiqin chengqi decoction (CQCQD) and its derivatives have been widely used in China for the early management of patients with acute pancreatitis (AP).
Li, Jiawang, Shi, Na, Phillips, Anthony R, Du, Dan, Jin, Tao, Xia, Qing, Han, Chenxia, Sutton, Robert, Wang, Rui, Wen, Yongjian, Liu, Tingting, Deng, Lihui, Fu, Xianghui, Yang, Jingyu, Huang, Wei, Mukherjee, Rajarshi, Windsor, John A, Jiang, Kun, Hong, Jiwon   +18 more
core   +2 more sources

Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells.

PLoS ONE, 2012
Cell-derived microparticles participate in intercellular communication similar to the classical messenger systems of small and macro-molecules that bind to specialized membrane receptors. Microparticles have been implicated in the regulation of a variety
Panpan Chen, Steven D Douglas, John Meshki, Florin Tuluc   +3 more
doaj   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, Volume 13, Issue 29, 22 May 2026.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

The culture of BMSC-OB and the expression of NK1R.

, 2016
(A) The osteobalsts derived from the second generation of BMSC after inoculation, the calcium deposition was observed at 3 weeks, x100. (B) The expression of NK1R in BMSC-OB was observed on plasma membranes and in cytoplasm (x400), and quantitative ...
Hai-Juan Liu (3232887), Hua Yan (211621), Liang Chen (73736), Jun Yan (28467), Hao Li (31608), Li-Ren Han (3232890), Xiao-Fei Yang (166798)   +6 more
core   +1 more source

Differential Effects of Calcium Alginate and Carboxymethylcellulose Wound Dressing Extracts on Human Sensory Neuron Regeneration and Secretome

Wound Repair and Regeneration, Volume 34, Issue 3, May/June 2026.
ABSTRACT The peripheral nervous system is critical for wound healing, with sensory nerves releasing neuropeptides that drive tissue repair. Sensory nerve damage impairs healing and contributes to chronic wounds, as observed in diabetic neuropathy. However, the impact of advanced wound dressings on peripheral nerves remains unexplored.
Maximin Serbier, Gilles Carpentier, Maria Sbeih, Laura Duciel, Céline Des Courtils, Alexis Desmoulière, Amandine Rovini   +6 more
wiley   +1 more source

Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation

Molecular Pain, 2007
Background There is a population of large neurons with cell bodies in laminae III and IV of the spinal dorsal horn which express the neurokinin 1 receptor (NK1r) and have dendrites that enter the superficial laminae. Although it has been shown that these
Watanabe Masahiko, MacIntyre Lynsey M, Campbell Annie D, Polgár Erika, Todd Andrew J   +4 more
doaj   +1 more source