Results 101 to 110 of about 3,155 (190)

Electroacupuncture on Baihui (DU20) and Xuehai (SP10) acupoints alleviates psoriatic inflammation by regulating neurotransmitter substance P- Neurokinin-1 receptor signaling

Journal of Traditional and Complementary Medicine
Background: At present, acupuncture-related practices have been widely used to treat psoriasis. In our study, we investigated the effect and explored the mechanism of electroacupuncture (EA) on acupoints Baihui (DU20) and Xuehai (SP10) for the treatment ...
Cong Qi, Fang Feng, JianNing Guo, Yu Liu, XiaoYao Guo, YuJiao Meng, TingTing Di, XueQing Hu, Yazhuo Wang, Ning Zhao, XiaWei Zhang, Yan Wang, Jingxia Zhao, Ping Li   +13 more
doaj   +1 more source

Design, Synthesis, and Evaluation of a Neurokinin-1 Receptor-Targeted Near-IR Dye for Fluorescence-Guided Surgery of Neuroendocrine Cancers

, 2016
The neurokinin-1 receptor (NK1R) is implicated in the growth and metastasis of many tumors, including cancers of the brain (e.g., gliomas, glioblastomas, and astrocytomas), skin (e.g., melanomas), and neuroendocrine tissues (cancers of the breast ...
Ananda Kumar Kanduluru (1418113), Philip S. Low (371711), Madduri Srinivasarao (2162374)   +2 more
core   +1 more source

In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

, 2020
AA3266 is a hybrid compound consisting of opioid receptor agonist and neurokinin-1 receptor (NK1R) antagonist pharmacophores. It was designed with the desire to have an analgesic molecule with improved properties and auxiliary anticancer activity ...
Katarzyna Kosińska, Joanna Matalińska, Piotr F. J. Lipiński, Piotr Kosson, Aleksandra Misicka   +4 more
core   +1 more source

The Inhibitory Effect of Botulinum Toxin Type A on Rat Pyloric Smooth Muscle Contractile Response to Substance P In Vitro

Toxins, 2015
A decrease in pyloric myoelectrical activity and pyloric substance P (SP) content following intrasphincteric injection of botulinum toxin type A (BTX-A) in free move rats have been demonstrated in our previous studies. The aim of the present study was to
Yu-Feng Shao, Jun-Fan Xie, Yin-Xiang Ren, Can Wang, Xiang-Pan Kong, Xiao-Jian Zong, Lin-Lan Fan, Yi-Ping Hou   +7 more
doaj   +1 more source

SP and NK1R: new targets in the treatment of chronic pruritus [PDF]

British Journal of Dermatology, 2019
S. Ständer, G. Yosipovitch
openaire   +1 more source

Epidermal PAR2‐TRPV3‐IL‐33 Signaling Promotes Mast Cell Recruitment and Sensory Nerve‐Mast Cell Interactions in Atopic Dermatitis

Allergy, Volume 81, Issue 5, Page 1898-1901, May 2026.
Jiahui Zhao, Lingxuan Zhou, Chenyu Wang, Ziyan Rao, Xiaohui Yuan, Jun Cui, Dongyu Zhao, Ying Sun, Yan Chen, Ruoyu Li, Miao Jing   +10 more
wiley   +1 more source

The influence of test experience and NK1 receptor antagonists on the performance of NK1R-/- and wildtype mice in the 5 Choice Serial Reaction Time Task [PDF]

, 2014
Genetically-altered mice, lacking functional NK1 receptors (NK1R-/-), express abnormal behaviours that are prominent in Attention Deficit Hyperactivity Disorder: namely, inattentiveness and impulsivity (indicated by their greater %omissions and premature
Ripley, TL, E M Grabowska (16220717), Weir, RK, T C Yan (16056029), J A Dudley (16220714), S C Stanford (13810018), Dudley, JA, Grabowska, EM, R K Weir (16220711), Stanford, SC, Tamzin Ripley (16042418), Yolanda Pena-Oliver (4462153), D N Stephens (16042424), Pena-Oliver, Y, Yan, TC, S P Hunt (13321284), Stephens, DN, Hunt, SP   +17 more
core  

Synaptic types between GABA-, glycine-, 5-HT- and DBH-immunoreactive terminals and NK1R-immunopositive somatic profiles and dendritic processes in MDH.

, 2013
Synaptic types between GABA-, glycine-, 5-HT- and DBH-immunoreactive terminals and NK1R-immunopositive somatic profiles and dendritic processes in MDH.
Le Yang (345935), Tao Chen (75911), Jian Qi (345934), Hua Zhang (12549), Yun-Qing Li (257982), Jun Guo (85069), Hui Li (32376), Sheng-Xi Wu (257979), Wen Wang (6570)   +8 more
core   +1 more source

Co-expression with NLPs increased solubility for NK1R, ADRB2, and DRD1 and retained their activity.

, 2012
(a) Comparison of GPCR solubility when expressed with or without NLPs. NK1R, ADRB2, and DRD1 were expressed as GFP fusion proteins. (b) The dot blot of GPCR-NLPs when incubating with (i) 100 nM fluorescent-labeled ligand and (ii) 100 nM fluorescent ...
John Voss (131458), Matthew A. Coleman (131460), Jitka Petrlova (131452), Tingjuan Gao (131450), Thomas Huser (131454), Wei He (131453), Wieslaw Kudlick (131456)   +6 more
core   +1 more source

Half-maximal effective concentration (EC₅₀) for selected ligands at NK1R or CCK2R.

, 2014
All values represent the mean from at least three independent experiments, each performed in triplicate.Half-maximal effective concentration (EC50) for selected ligands at NK1R or CCK2R.
Wei-En Lin (659082), Benjamin N. Harwood (659080), Subrahmanian Tarakkad Krishnaji (659081), Jamie R. Doyle (659079), Alan S. Kopin (205413), Vijay M. Krishnamurthy (385540), Jean-Philippe Fortin (205405), Krishna Kumar (385545)   +7 more
core   +1 more source