Results 111 to 120 of about 3,155 (190)

Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea

, 2003
The role of the NK1 receptor in airway contraction induced by electrical field stimulation (EFS) was evaluated by comparing the response in NK1 receptor knockout mice (NK1R-/-) with that of NK1 receptor wild-type controls (WT).
G.F. Joos, K.G. Tournoy, R.A. Pauwels, R.A. Lefebvre, Tournoy, Kurt, Joos, Guy, K.O. De Swert, De Swert, Katelijne, LECLERE, PG, Lefebvre, Romain, Pauwels, Romain, P.G. Leclere   +11 more
core   +1 more source

Knockout of the Tachykinin Receptor 1 in the Mdr2−/− (Abcb4−/−) Mouse Model of Primary Sclerosing Cholangitis Reduces Biliary Damage and Liver Fibrosis

, 2020
Activation of the substance P (SP)/neurokinin 1 receptor (NK1R) axis triggers biliary damage/senescence and liver fibrosis in bile duct ligated and Mdr2−/− (alias Abcb4−/−) mice through enhanced transforming growth factor-β1 (TGF-β1) biliary secretion ...
Glaser S., Meng F., Ceci L., Franchitto A., Kennedy L., Giang T., Francis H., Meadows V., Liangpunsakul S., Alpini G., Wu C., Sybenga A., Mancinelli R., Kyritsi K., Zhou T., Yang Z., Wu N., Onori P., Ekser B., Gaudio E., Francis, Heather, Zhou, Tianhao, Glaser, Shannon, Zhihong Yang, Chaodong Wu, Giang, Thao, Gianfranco Alpini, Kyritsi, Konstantina, Sybenga, Amelia, Amelia Sybenga, Alpini, Gianfranco, Heather Francis, Lindsey Kennedy, Franchitto, Antonio, Onori, Paolo, Konstantina Kyritsi, Wu, Nan, Antonio Franchitto, Meadows, Vik, Mancinelli, Romina, Wu, Chaodong, Eugenio Gaudio, Shannon Glaser, Liangpunsakul, Suthat, Meng, Fanyin, Ceci, Ludovica, Ekser, Burcin, Paolo Onori, Fanyin Meng, Romina Mancinelli, Yang, Zhihong, Nan Wu, Tianhao Zhou, Burcin Ekser, Suthat Liangpunsakul, Gaudio, Eugenio, Kennedy, Lindsey, Thao Giang, Vik Meadows, Ludovica Ceci   +59 more
core   +1 more source

Saturation binding assay of FAM-SP on filter paper after interacting with NK1R-NLPs.

, 2012
The fluorescence intensity was averaged through 3 replicates with the error bar showing the standard deviation. Each data point represented intensity of different amounts of FAM-SP interacting with NK1R-NLPs subtracted by non-specific adsorption of the ...
John Voss (131458), Matthew A. Coleman (131460), Jitka Petrlova (131452), Tingjuan Gao (131450), Thomas Huser (131454), Wei He (131453), Wieslaw Kudlick (131456)   +6 more
core   +1 more source

Zuogui Wan alleviates ovariectomy-induced osteoporosis by maintaining FoxO3 and increasing NK1R

Cellular and Molecular Biology, 2023
Xing, Li, Feng, Tan, Dan, Wu, Congying, Mai, Huaquan, Guan, Qiaoling, Fan   +5 more
openaire   +2 more sources

The NK1R-/- mouse phenotype suggests that small body size, with a sex- and diet-dependent excess in body mass and fat, are physical biomarkers for a human endophenotype with vulnerability to attention deficit hyperactivity disorder. [PDF]

, 2016
The abnormal behaviour of NK1R-/- mice (locomotor hyperactivity, inattentiveness and impulsivity in the 5-Choice Serial Reaction-Time Test) is arguably analogous to that of patients with attention deficit hyperactivity disorder (ADHD).
Stanford, SC, Pillidge, K, Heal, DJ
core  

Fluorescent Probes for Monitoring Ligand Binding and Receptor Trafficking and Internalisation

, 2018
The Neurokinin 1 receptor (NK1R) is associated with neurogenic inflammation and nociceptive transmission through signal propagation by the endogenous agonist, substance P.
JOSHUA WILLIAM CONNER (6092108)
core   +1 more source

Possible Mechanism of Action of Neurokinin-1 Receptors (NK1R) Antagonists [PDF]

Journal of Pharmacy and Pharmacology, 2017
null Özüm Öztürk, null Esin Aki-Yalcin, null Tugba Ertan-Bolelli, null Kayhan Bolelli, null Andry Nur-Hidayat, null Ozlem Bingol-Ozakpinar, null Filiz Ozdemir, null Ismail Yalcin   +7 more
openaire   +1 more source

Perseveration by NK1R-/- ('knockout') mice is blunted by doses of methylphenidate that affect neither other aspects of their cognitive performance nor the behaviour of wild-type mice in the 5-Choice Continuous Performance Test [PDF]

, 2016
The underlying cause(s) of abnormalities expressed by patients with attention deficit hyperactivity disorder (ADHD) have yet to be delineated. One factor that has been associated with increased vulnerability to ADHD is polymorphism(s) ofTACR1, which is ...
Young, JW, Stanford, SC, Pillidge, K, Porter, AJ   +3 more
core  

Intracellular pocket and ICL2 motifs govern G-protein coupling bias in NK₁ receptor (TACR1) and NK₂ receptor (TACR2). [PDF]

J Biol Chem
Petersen JE, Pavlovskyi A, Madsen JJ, Schwartz TW, Frimurer TM, Olsen OH.   +5 more
europepmc   +1 more source

RETRACTION: The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein. [PDF]

Neurol Res Int
Research International N.
europepmc   +1 more source