Results 91 to 100 of about 3,155 (190)

Microdialysis of a NK1R antagonist into the ventral medulla does not affect breathing frequency

The FASEB Journal, 2013
Previous studies in vivo have found an excitatory effect on breathing frequency (f) of microdialysis (MD) of Atropine into regions of the ventral medulla within the vicinity of the pre‐Bötzinger Complex (pre‐BötC) ( FASEB J , 25: 1074.1, 2011).
Muere, Clarissa, Miller, Justin, Neumueller, Suzanne, Olesiak, Samantha, Mouradian, Gary, Martino, Paul, Pan, Lawrence, Hodges, Matthew, Forster, Hubert   +8 more
openaire   +2 more sources

730 Truncated neurokinin 1 receptor (NK1R) is the predominant form of NK1R in human keratinocytes [PDF]

Journal of Investigative Dermatology, 2018
S.G. Kwatra, K.A. Whang, E. Boozalis, C. Roberts, M.M. Kwatra   +4 more
openaire   +1 more source

The behavioural response of NK1R-/- mice to guanfacine resembles its clinical profile in treatment of ADHD. [PDF]

, 2014
Mice with functional ablation of substance P-preferring neurokinin-1 receptors (NK1R-/-) display behavioural abnormalities resembling those seen in Attention Deficit Hyperactivity Disorder (ADHD).
Stanford, SC, Pillidge, K, Tsai, YC, Heal, DJ, Porter, AJ, Dudley, JA   +5 more
core  

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature Communications, 2019
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is ...
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao   +14 more
doaj   +1 more source

Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

Journal of Pharmacological Sciences, 2010
We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK1 R) in the development of radiation-induced hair loss in mice.
Kouichi Yamamoto, Naoko Kureyama, Keiko Asano, Toshiji Ikeda, Atsushi Yamatodani   +4 more
doaj   +1 more source

Exosomes from mesenchymal stem/stromal cells and their therapeutic role in osteoarthritic pain

Journal of Experimental Orthopaedics, Volume 13, Issue 3, July 2026.
Dimitrios Kouroupis, Stanislava Jergova, Jacqueline Sagen, Thomas M. Best   +3 more
wiley   +1 more source

Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor

Journal of Pharmacological Sciences, 2013
.: To clarify a role of substance P (SP) in an endogenous pain control mechanism involving the rat striatum, striatal SP release was measured over time by microdialysis following intraplantar injection of 0.4% formalin.
Yoki Nakamura, Hiroki Izumi, Takumi Shimizu, Kazue Hisaoka-Nakashima, Norimitsu Morioka, Yoshihiro Nakata   +5 more
doaj   +1 more source

Raised arterial blood pressure in neurokinin-1 receptor-deficient mice (NK1R−/−): evidence for a neural rather than a vascular mechanism [PDF]

, 2016
NEW FINDINGS: What is the central question of this study? Does genetic ablation of neurokinin-1 receptors alter arterial blood pressure? What is the main finding and its importance?
Hobbs, AJ, Stanford, SC, Ramage, AG, Moyes, AJ, Hosford, PS   +4 more
core  

Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis

Acta Pharmaceutica Sinica B
Acute pancreatitis (AP) is a life-threatening gastrointestinal disorder for which no effective pharmacological treatments are currently available. One of the pharmacological targets that merits further research is the neurokinin 1 receptor (NK1R), which ...
Chenxia Han, Lu Li, Lin Bai, Yaling Wu, Jiawang Li, Yiqin Wang, Wanmeng Li, Xue Ren, Ping Liao, Xiaoting Chen, Yaguang Zhang, Fengzhi Wu, Feng Li, Dan Du, Qing Xia   +14 more
doaj   +1 more source

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon [PDF]

, 2014
The substance P neurokinin 1 receptor (NK1R) regulates motility, secretion, inflammation and pain in the intestine. The distribution of the NK1R is a key determinant of the functional effects of substance P in the gut.
Bunnett, NW, Poole, DP, Pelayo, JC, Eriksson, EM, Veldhuis, NA   +4 more
core   +1 more source