Results 31 to 40 of about 3,155 (190)
NK1 receptor binding of a few low molecular weight 3,5-bistrifluoromethylbenzene derivatives [PDF]
Acta Poloniae Pharmaceutica, 2023 We were interested in finding smallest possible ligands of the NK1 receptor (NK1R). Based on structural considerations and molecular docking (scoring) we selected six simple (low molecular weight, MW) 3,5-bistrifluoromethylbenzene derivatives and tested ...
Piotr F. J. Lipiński +1 more
doaj +1 more source
Pharmacologic rationale for the NK1R antagonist, aprepitant as adjunctive therapy in HIV [PDF]
Journal of Translational Medicine, 2016 Many HIV infected individuals with suppressed viral loads experience chronic immune activation frequently developing neurological impairment designated as HIV associated neurocognitive disorder (HAND). Adjunctive therapies may reduce HIV associated inflammation and therefore decrease the occurrence of HAND.We have conducted in vitro, animal and ...
Barrett, Jeffrey S. +9 more
openaire +2 more sources
Journal of Neuroinflammation, 2022 Background Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases.
Peng Jin +7 more
doaj +1 more source
Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord. [PDF]
PLoS ONE, 2013 Substance P (SP) and its receptor, the neurokinin 1 receptor (NK1R), play important roles in transmitting and regulating somatosensory nociceptive information.
Ming-Ming Zhang +9 more
doaj +1 more source
International Journal of Breast Cancer, 2022 Background. Neurokinin 1 receptor (NK1R) is a promising biomarker and therapeutic target in breast cancer. This study was aimed at investigating the expression level of NK1R in breast cancer tissues and its relationship with proliferation index as ...
Maha S. Al-Keilani +2 more
doaj +1 more source
Pharmaceutics, 2019 To date, our understanding of the Substance P (SP) and neurokinin 1 receptor (NK1R) system shows intricate relations between human physiology and disease occurrence or progression.
Agnieszka Majkowska-Pilip +2 more
doaj +1 more source
Substance P Receptor in the Rat Heart and Regulation of Its Expression in Long-Term Diabetes
Frontiers in Physiology, 2018 Substance P (SP) is a neuropeptide engaged in the signal transmission of neural C fibers afferents in the myocardium. The actions of SP in the heart are extensive and they are mediated by the neurokinin 1 receptor (NK1R), a member of the tachykinin ...
Magdalena Chottova Dvorakova +6 more
doaj +1 more source
, 2023 Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging.
Shunuo Zhang (11894687) +6 more
core +1 more source
Journal of Neuroinflammation, 2018 Background Several psychiatric conditions are affected by neuroinflammation and neuroimmune activation. The transcription factor nuclear factor kappa light-chain-enhancer of activated B cells (NFkB) plays a major role in inflammation and innate immunity.
Hannah D. Fulenwider +7 more
doaj +1 more source
, 2023 Diabetes is a global disease with huge impacts on patients due to its complications, among which non-healing wounds and depression are common and challenging.
Shunuo Zhang (11894687) +6 more
core +1 more source