Substance P and NK‐1R in Dengue: A First Serological Investigation [PDF]
Health Science ReportsBackground Dengue fever lacks reliable biomarkers to explain its complex pathophysiology. Substance P (SP) and its receptor, the Neurokinin‐1 receptor (NK1R), known regulators of inflammation and vascular permeability in viral infections, may play a role
Riffat Mehboob +7 more
doaj +3 more sources
Perioperative substance P/NK1R pharmacology: from PONV control to a testable cancer neuro-immune hypothesis [PDF]
Frontiers in ImmunologyThe perioperative period is increasingly recognized as a biologically active interval in which surgical injury, anesthetic exposure, neuroendocrine stress, pain, opioid use, and innate immune remodeling may influence residual tumor-cell ecology ...
Jing Zhao, Zhongwei Liu, Jun Wang
doaj +3 more sources
Substance P-NK1R signaling of keratinocytes initiates the skin inflammatory environment required for allergic contact dermatitis [PDF]
JCI InsightAllergic contact dermatitis (ACD), a recurrent inflammatory skin disorder, affects 21% of humans and is the second leading cause of occupational diseases in USA.
William Shufesky +7 more
core +2 more sources
Cancer‐related pain: A bidirectional modulator of cancer progression [PDF]
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He +5 more
wiley +2 more sources
Broadening the View: Substance P and Its Metabolism in Pruritus‐Related Diseases [PDF]
The Journal of Dermatology, Volume 53, Issue 7, Page 967-979, July 2026.ABSTRACT Chronic pruritus is a debilitating symptom accompanying numerous inflammatory skin diseases and remains a major therapeutic challenge. Neurogenic inflammation plays a central role in its pathogenesis, with the tachykinin substance P acting as a key mediator at the interface of the nervous system, immune cells, and cutaneous tissues.
Thomas Walter, Bjoern B. Burckhardt
wiley +2 more sources
Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma [PDF]
Advanced Science, EarlyView.Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li +11 more
wiley +2 more sources
The C‐terminal truncated splicing variant of
FEBS Open BioMammalian neurokinin 1 receptor (NK1R) exists as full‐length (NK1L) and truncated (NK1S) splice variants. However, the functional role of NK1S remains controversial; therefore, we investigated their functional interplay. Using NanoBiT and co‐immunoprecipitation, we demonstrate that NK1L and NK1S form heterodimeric complexes ...
Lan Phuong Nguyen +8 more
openaire +2 more sources
AntioxidantsSubstance P (SP), encoded by the TAC1/Tac1 gene, acts as a significant mediator in dysregulated systemic inflammatory response and associated organ injury in sepsis by activating the neurokinin-1 receptor (NK1R).
Zhixing Zhu +2 more
doaj +2 more sources
Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis [PDF]
Cerebral Cortex, 2018 We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis. The hypocretins (orexins) are wake-promoting neuropeptides and hypocretin/orexin (Hcrt) neurons project to the cortex. Hcrt peptides affect deep layer cortical neurons, and Hcrt receptor 1 (Hcrtr1; Ox1r) mRNA is expressed in cortical nNOS/NK1R cells.
Rhîannan H Williams +5 more
openaire +5 more sources
Diagnostic and Therapeutic Potential of Substance P/NK1 Receptor in Primary Dysmenorrhea: A Pilot Study [PDF]
Health Science ReportsBackground and Aims Primary dysmenorrhea is a prevalent condition that causes significant menstrual pain and discomfort, impacting many women′s daily activities.
Riffat Mehboob +8 more
doaj +2 more sources