Results 31 to 40 of about 113,904,810 (178)

The Potential In Vitro Inhibitory Effects of Neurokinin‐1 Receptor (NK‐1R) Antagonist, Aprepitant, in Osteosarcoma Cell Migration and Metastasis

BioMed Research International, 2022
Background. Osteosarcoma, the most frequent osteogenic malignancy, has become a serious public health challenge due to its high morbidity rates and metastatic potential. Recently, the neurokinin‐1 receptor (NK‐1R) is proved to be a promising target in cancer therapy. This study is aimed at determining the effect
Mohammed Ali Alsaeed, Safieh Ebrahimi, Abbas Alalikhan, Seyedeh Fatemeh Hashemi, Seyed Isaac Hashemy   +4 more
openaire   +2 more sources

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]

, 2008
Background: Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
David A Groneberg, Groneberg, David A., Wagner, Ulrich, Groneberg, Jan David Alexander, Groneberg David A, Staats Petra, Schmidt Rene, Ulrich Wagner, Schmidt, Rene, Petra Staats, Staats, Petra, Rene Schmidt, Wagner Ulrich   +12 more
core   +1 more source

Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation

BMC Cancer, 2023
Background Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tumors.
Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Wang, Xianxiu Ge, Fei Wang, Fangfang Zhou, Xueting Deng, Lin Miao   +9 more
doaj   +1 more source

Aprepitant attenuates NLRC4-dependent neuronal pyroptosis via NK1R/PKCδ pathway in a mouse model of intracerebral hemorrhage

Journal of Neuroinflammation, 2022
Background Pyroptosis is a programmed cell death mediated by inflammasomes. Previous studies have reported that inhibition of neurokinin receptor 1 (NK1R) exerted neuroprotection in several neurological diseases.
Peng Jin, Dongqing Qi, Yuhui Cui, Cameron Lenahan, John H. Zhang, Xiaogen Tao, Shuixiang Deng, Jiping Tang   +7 more
doaj   +1 more source

Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography

Nature Communications, 2019
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which is ...
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao   +14 more
doaj   +1 more source

The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein

Neurology Research International, 2021
Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani, Mohammad Reza Vaezi Kakhki, Hossein Javid, Safieh Ebrahimi, Seyed Isaac Hashemy   +4 more
doaj   +1 more source

The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone [PDF]

Korean Journal of Anesthesiology, 2012
BackgroundThe purpose of this study was to evaluate the effect of an aprepitant, neurokinin-1(NK1) receptor antagonist, for reducing postoperative nausea and vomiting (PONV) for up to 24 hours in patients regarded as high risk undergoing gynecological ...
Se-Jin Lee, Su Myung Lee, Soon Im Kim, Si Young Ok, Sang Ho Kim, Sun-Young Park, Mun-Gyu Kim   +6 more
doaj   +1 more source

Detection of an Antagonist Bound to the Neurokinin a Receptor in Styrene-Maleic Acid Lipid Particles by ¹⁹F Ultrafast Magic-Angle Spinning Nuclear Magnetic Resonance Spectroscopy. [PDF]

Chembiochem
The detection of a fluorinated antagonist bound to the neurokinin A receptor by 19F ultrafast MAS NMR is demonstrated. Therefore, the receptor is purified by detergent‐free extraction by styrene maleic acid copolymer encapsulation and subsequently characterised.
Seidl S, Patra AP, Li C, Becker-Baldus J, Kaiser S, Reinhart C, Glaubitz C.   +6 more
europepmc   +2 more sources

Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance [PDF]

, 2022
SIMPLE SUMMARY: Improving the response, quality of life and survival of oncologic patients through the design and application of the most appropriate treatment for each case is a great scientific challenge.
Téllez, Teresa, Redondo-Bautista, Maximino, Teresa Téllez, Redondo, Maximino, McKenna, Lauraine, Marilina García-Aranda, Maximino Redondo, Téllez-Santana, Teresa, Lauraine McKenna, García Aranda, Marilina, García-Aranda, Marilina   +10 more
core   +1 more source

Differential effects of aprepitant, a clinically used neurokinin-1 receptor antagonist on the expression of conditioned psychostimulant versus opioid reward [PDF]

Psychopharmacology, 2016
Neurokinin-1 receptor (NK1R) signaling modulates behaviors associated with psychostimulants and opioids. Psychostimulants, such as amphetamine (AMPH) and cocaine, bind to monoamine transporters and alter their functions. Both dopamine and norepinephrine transporters are regulated by NK1R activation suggesting a role for NK1R mediated catecholamine ...
Padmanabhan, Mannangatti, Santhanalakshmi, Sundaramurthy, Sammanda, Ramamoorthy, Lankupalle D, Jayanthi   +3 more
openaire   +2 more sources