Results 41 to 50 of about 113,904,810 (178)

The Effect of SP/NK1R on the Expression and Activity of Catalase and Superoxide Dismutase in Glioblastoma Cancer Cells

Biochemistry Research International, 2021
Introduction. Glioblastoma is the most malignant brain tumor with different therapeutic protocols, including surgery, radiotherapy, and chemotherapy. Substance P (SP), a peptide released by sensory nerves, increases cellular excitability by activating ...
Faranak Korfi, Hossein Javid, Reza Assaran Darban, Seyed Isaac Hashemy   +3 more
doaj   +1 more source

Neurokinin Receptor 1 (NK1R) Antagonist Aprepitant Enhances Hematoma Clearance by Regulating Microglial Polarization via PKC/p38MAPK/NFκB Pathway After Experimental Intracerebral Hemorrhage in Mice

, 2021
Hematoma clearance is an important therapeutic target to improve outcome following intracerebral hemorrhage (ICH). Recent studies showed that Neurokinin receptor-1 (NK1R) inhibition exerts protective effects in various neurological disease models, but ...
Travis, Zachary D., Huang, Lei, Lenahan, Cameron, Tang, Jiping, Lian, Lifei, Sherchan, Prativa, Cui, Yuhui, Xie, Shucai, Deng, Shuixiang, Li, Gaigai, Zhang, John H., Gong, Ye, Jin, Peng, Lei Huang, Yuhui Cui, Shucai Xie, Jiping Tang, Shuixiang Deng, Zachary D. Travis, Prativa Sherchan, Cameron Lenahan, Gaigai Li, John H. Zhang, Lifei Lian, Ye Gong, Peng Jin   +25 more
core   +1 more source

Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells

Folia Neuropathologica, 2020
A neuropeptide, Substance P (SP), has mitogenic action in many types of cancer cells mediated via the neurokinin-1 receptor (NK1R). Small molecular NK1R antagonists have been frequently shown to possess anticancer activity both in vivo and in vitro, but ...
Joanna Matalińska, Agnieszka Świć, Piotr Lipiński, Aleksandra Misicka   +3 more
doaj   +1 more source

Evaluation of a neurokinin-1 antagonist in preventing multiple-day cisplatin-induced nausea and vomiting

, 2018
To perform a prospective non-randomized comparison of the effectiveness and safety of combined neurokinin-1 antagonist aprepitant treatment with the standard multiple-day cisplatin regimen for the prevention of cisplatin-induced nausea and vomiting (CINV)
Wang Wenjuan, Hu Yuliang, Jiang Caihong, Wu Yungaowa, Li Quanfu, Jin Gaowa, Deng Shuqin, Bai Xiaojun, Chen Gang, Chen Feng, Zhao Jun, Da Lenggaowa, Li Hui   +12 more
core   +2 more sources

Two Cases of Fatal Encephalopathy Related to Ifosfamide: An Adverse Role of Aprepitant

Case Reports in Oncology, 2014
Ifosfamide is used in the treatment of sarcomas and other tumors. It sometimes provokes encephalopathy, which is a serious complication even if it is usually reversible within 48-72 h after drug cessation.
Alice Séjourné, Sabine Noal, Mathieu Boone, Céline Bihan, Marion Sassier, Michel Andrejak, Bruno Chauffert   +6 more
doaj   +1 more source

Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR

Cell Death and Disease, 2022
Despite the great advances in target therapy, lung cancer remains the top cause of cancer-related death worldwide. G protein-coupled receptor neurokinin-1 (NK1R) is shown to play multiple roles in various cancers; however, the pathological roles and ...
Xiao-Wei Zhang, Lin Li, Wen-Qian Hu, Ming-Ning Hu, Yan Tao, Hui Hu, Xiao-Kang Miao, Wen-Le Yang, Qiong Zhu, Ling-Yun Mou   +9 more
doaj   +1 more source

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

Acta Dermato-Venereologica, 2017
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients ...
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz   +7 more
doaj   +1 more source

Why Use Aprepitant Only as a Cough Suppressant in Lung Cancer When at Higher Doses it Could Also Exert an Antitumor Action?

, 2022
Effective antitussive cough treatments are an important need in patients with lung cancer LC Aprepitant drug a selective neurokinin-1 receptor NK-1R antagonist and used for the treatment of nausea vomiting blocks the activation of the receptor by ...
Coveñas, Rafael, Muñoz, Miguel, Muñoz, Miguel E, Morell, Ferran, Rafael Coveñas, Miguel Muñoz, Ferran Morell, Miguel E. Muñoz   +7 more
core   +1 more source

Antitumor Strategies Targeting Peptidergic Systems

Encyclopedia
Peptidergic systems show promise as targets for fighting tumors. While some peptides encourage the growth and spread of tumor cells and angiogenic mechanisms, others display antitumor properties. As such, peptide ligands and receptor antagonists could be
Francisco D. Rodríguez, Rafael Coveñas
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source