Results 71 to 80 of about 113,904,810 (178)

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, L. D. D'Andrea, NASTRI, FLAVIA, F. Rossi, F. Nastri, L. D. DANDREA, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO, Rossi F, Filippelli A, Falciani M, Pavone, D'Agostino, D'Andrea, L D, V, Lombardi A, B Nastri F   +23 more
core   +1 more source

Safety, efficacy, and patient acceptability of single-dose fosaprepitant regimen for the prevention of chemotherapy-induced nausea and vomiting

Patient Preference and Adherence, 2013
Luigi Celio, Francesca Ricchini, Filippo De BraudMedical Oncology Unit 1, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyAbstract: Control of chemotherapy-induced nausea and vomiting (CINV) is a crucial factor in ...
Celio L, Ricchini F, De Braud F
doaj  

Comparison of single-dose oral aprepitant and intravenous ondansetron for the prevention of post-operative nausea and vomiting in patients undergoing open abdominal surgery

Asian Journal of Medical Sciences
Background: Post-operative nausea and vomiting (PONV) remains one of the most common and distressing complications following general anesthesia, particularly after open abdominal surgery.
Mohd Rafiq Mir , Nowsheeba Rashid , Aaqib Suhail Mir , Waqrul Neesa   +3 more
doaj   +1 more source

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists [PDF]

, 2019
Neurokinins (or tachykinins) are peptides that modulate a wide variety of human physiology through the neurokinin G protein-coupled receptor family, implicated in a diverse array of pathological processes.
Schöppe, Jendrik; https://orcid.org/, Plückthun, Andreas; https://orcid.org/, Schütz, Marco, Klenk, Christoph; https://orcid.org/, Doré, Andrew S, Ehrenmann, Janosch; https://orcid.org/, Rucktooa, Prakash, Ehrenmann, Janosch (author), Andreas Plückthun, Rucktooa P, Andrew S. Doré, Schöppe J, Klenk, Christoph (author), Prakash Rucktooa, Klenk C, Janosch Ehrenmann, Christoph Klenk, Schütz M, Doré, Andrew S. (author), Schütz, Marco (author), Doré AS, Marco Schütz, Ehrenmann J, Plückthun A, Plückthun, Andreas (author), Schöppe, Jendrik (author), Jendrik Schöppe, Rucktooa, Prakash (author)   +27 more
core   +1 more source

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Drug Design, Development and Therapy, 2017
Bernardo Leon Rapoport,1 Matti Aapro,2 Martin R Chasen,3 Karin Jordan,4 Rudolph M Navari,5 Ian Schnadig,6 Lee Schwartzberg7 1The Medical Oncology Centre of Rosebank, Johannesburg, South Africa; 2Breast Center, Genolier Cancer Center, Genolier ...
Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L   +6 more
doaj  

Efficacy and Safety of Conventional and Biologic Therapies in Prurigo Nodularis: A Systematic Review and Meta‐Analysis

International Journal of Dermatology, Volume 65, Issue 4, Page 724-736, April 2026.
ABSTRACT Prurigo nodularis (PN) is a chronic, intensely pruritic skin disorder characterized by hyperkeratotic nodules and a debilitating itch–scratch cycle. Conventional therapies have limited efficacy and safety issues, while biologics have recently emerged as a promising alternative.
Andrea Lancz, Fanni Adél Meznerics, Renáta Árok, Anna Sára Lengyel, Bence Szabó, Péter Hegyi, Norbert Kiss, András Bánvölgyi   +7 more
wiley   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Potent, Brain-Penetrant, Hydroisoindoline-Based Human Neurokinin-1 Receptor Antagonists

, 2016
3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one (17) is a high affinity, brain-penetrant, hydroisoindoline-based neurokinin-1 (NK1) receptor antagonist with a long ...
Terence Hamill (2375251), Marc M. Kurtz (2375242), Alana Upthagrove (2375236), Song Zheng (2375248), Kwei-Lan C. Tsao (2125189), Jinlong Jiang (1394881), Xinchun Tong (2065036), Alan Wheeldon (2375257), Geoge A. Doss (2375245), WaiSi Eng (2375239), Stephen M. Krause (2375260), Sanjeev Kumar (377400), Robert J. DeVita (523842), Christine Ryan (2259877), Gary G. Chicchi (1780462), Emma J. Carlson (2375254), Donald Burns (2375266), Jaime L. Bunda (2375263), Richard Tschirret-Guth (2125198), Richard Hargreaves (269258), Sander G. Mills (2085178), Koppara Samuel (1370235)   +21 more
core   +1 more source

Progress in Gastroparesis Management: From Pharmacotherapy to Interventional Treatments

JGH Open, Volume 10, Issue 3, March 2026.
ABSTRACT Gastroparesis is a sensorimotor condition characterized by delayed gastric emptying without any obvious mechanical obstruction. Common symptoms include early satiety, nausea, vomiting, belching, and bloating. The most frequent causes of gastroparesis are diabetes, idiopathic factors, and post‐surgical complications.
Ganesh Kumar, Yash Shah, Ume Rooman, Ravi Patel, Shireen Asifa, Qais M. Salah, Dushyant Singh Dahiya, Arkadeep Dhali, Camelia Arsene, Meer Ali   +9 more
wiley   +1 more source