Results 81 to 90 of about 44,465 (273)

Aprotinina não influencia troponina I, NTproBNP e função renal em crianças operadas com circulação extracorpórea High-dose aprotinin does not affect troponin I, N-Terminal pro-B-type natriuretic peptid and renal function in children submitted to surgical correction with extracorporeal circulation

Brazilian Journal of Cardiovascular Surgery, 2009
OBJETIVO: Avaliar se o uso de aprotinina em altas doses hemostáticas pode influenciar as funções miocárdicas, renais e metabólicas em crianças operadas com circulação extracorpórea (CEC). MÉTODOS: Estudo prospectivo randomizado em crianças de 30 dias a 4
Cesar Augusto Ferreira, Walter Villela de Andrade Vicente, Paulo Roberto Barbosa Évora, Alfredo José Rodrigues, Jyrson Guilherme Klamt, Ana Paula de Carvalho Panzeri Carlotti, Fábio Carmona, Paulo Henrique Manso   +7 more
doaj   +1 more source

Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.

British Journal of Anaesthesia, 2012
BACKGROUND A significantly increased risk of acute kidney injury (AKI) with the prophylactic use of aprotinin has been reported in adults undergoing cardiac surgery, but not in children.
M. Bojan, S. Vicca, C. Boulat, S. Gioanni, Philippe Pouard   +4 more
semanticscholar   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Fabricating Microfluidic Co‐Cultures of Immortalized Cell Lines Uncovers Robust Design Principles for the Simultaneous Formation of Patterned, Vascularized, and Stem Cell‐Derived Adipose Tissue

Small, EarlyView.
Murphy et al present an optimized co‐culture protocol for immortalized cell line vasculogenesis. Here, immortalized co‐cultures form reproducible microvessel networks across 31‐days, while gradient microchips enable simultaneous mesenchymal stem cell (MSC) adipogenesis and endothelial cell (EC) vasculogenesis.
Ashley R. Murphy, Rose Ann Franco, Mark C. Allenby   +2 more
wiley   +1 more source

Curcumin ameliorates hyperuricemia and gout‐induced damage via modulating the ROS‐dependent NEK7‐NLRP3 inflammasome activation

Smart Molecules, EarlyView.
Curcumin inhibits the ROS/NEK7‐NLRP3 inflammasome pathway by reducing reactive oxygen species (ROS) levels and disrupting the association of the NEK7‐NLRP3 complex. These combined effects of curcumin result in suppression of the GSDMD‐N pyroptotic pore formation and subsequent reduction of IL‐1β release.
Zhengtian Zhao, Xiaowei Tong, Jing Sun, Jiaqi Lu, Guangyu Zhang, Qing Wang, Li Yang   +6 more
wiley   +1 more source

The novel serine protease PreR-Co promotes endothelium-independent vasorelaxation in rabbit aortic rings [PDF]

, 2003
The effect of a novel enzyme (PreR-Co) that activates renal prorenin was studied on rabbit aortas with and without endothelium. It was tested 1) in the basal tone of nonstimulated or ANG II-sensitized rings or rings precontracted with norepinephrine (NE),
Coviello, Alfredo, de Vito, Eduardo, Guardia, Dora Cecilia, Peral, Maria de Los Angeles, Romano, Monica Liliana, Vincent, Paula Andrea   +5 more
core   +1 more source

Effect of aging on the development and progression of alcohol‐associated liver disease

Alcohol, Clinical and Experimental Research, Volume 49, Issue 7, Page 1412-1423, July 2025.
Age is a predictor for alcohol‐associated liver disease (ALD)‐related mortality. This study investigates the effects of aging on the ethanol‐induced development and progression of ALD in rats. This study demonstrates that chronic ethanol feeding increased liver injury markers and hepatic triglycerides across all age groups.
Ramesh Bellamkonda, Sundararajan Mahalingam, Ojeshvi Ethiraj, Sathish Kumar Perumal, Madan Kumar Arumugam, Daren L. Knoell, Kurt W. Fisher, Carol A. Casey, Kusum K. Kharbanda, Karuna Rasineni   +9 more
wiley   +1 more source

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Protective effects of the antioxidant Ginkgo biloba extract and the protease inhibitor aprotinin against Leiurus quinquestriatus venom-induced tissue damage in rats

Journal of Venomous Animals and Toxins including Tropical Diseases, 2006
Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries
A. J. Fatani, H. A. Al-Zuhair, H. I. Yaquob, A. A. Abdel-Fattah, M. I. El-Sayed, F. A. El-Sayed   +5 more
doaj   +1 more source

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source