Results 81 to 90 of about 114,758 (340)

A Molecular Basis for Stabilization of the von Hippel-Lindau (VHL) Tumor Suppressor Protein by Components of the VHL Ubiquitin Ligase [PDF]

, 2002
The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBCVHL, Cul2-Elongin BC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a heterodimeric module composed of a ...
Brower, Christopher S., Conaway, Joan W., Conaway, Ronald C., Kamura, Takumi   +3 more
core   +2 more sources

Opuntia ficus‐indica fruit consumption improves insulin resistance in mice with diet‐induced obesity

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity induces various co‐morbidities including insulin resistance. Opuntia ficus‐indica fruit (OFIF) is rich in various beneficial compounds with antioxidant and anti‐inflammatory properties. The present study evaluated the efficacy of OFIF supplementation to counteract obesity‐induced insulin resistance in comparison with an ...
Simona Terzo, Pasquale Calvi, Ignazio Restivo, Alessandro Massaro, Luisa Tesoriere, José‐Manuel Fernández‐Real, Marta Giardina, Antonella Amato, Flavia Mulè, Mario Allegra   +9 more
wiley   +1 more source

Curcumin ameliorates hyperuricemia and gout‐induced damage via modulating the ROS‐dependent NEK7‐NLRP3 inflammasome activation

Smart Molecules, EarlyView.
Curcumin inhibits the ROS/NEK7‐NLRP3 inflammasome pathway by reducing reactive oxygen species (ROS) levels and disrupting the association of the NEK7‐NLRP3 complex. These combined effects of curcumin result in suppression of the GSDMD‐N pyroptotic pore formation and subsequent reduction of IL‐1β release.
Zhengtian Zhao, Xiaowei Tong, Jing Sun, Jiaqi Lu, Guangyu Zhang, Qing Wang, Li Yang   +6 more
wiley   +1 more source

Extracellular serine-proteinases isolated from Streptomyces alboniger: Partial characterization and effect of aprotinin on cellular structure

Memorias do Instituto Oswaldo Cruz, 1999
Streptomyces alboniger ATCC 12461 grown in brain heart infusion (BHI) medium produced two extracellular serine-proteinases, denoted SP I and SP II, which were purified by ammonium sulfate precipitation and aprotinin-agarose affinity chromatography.
Lopes Andréa, Coelho Rosalie RR, Meirelles Maria Nazareth L, Branquinha Marta Helena, Vermelho Alane Beatriz   +4 more
doaj  

Injured tissues favor cancer cell implantation via fibrin deposits on scar zones

Neoplasia: An International Journal for Oncology Research, 2020
Aim: Evaluation of fibrin role on cancer cells implantation in injured tissues and studying the molecular mechanism of cancer cell interaction with the peritoneal damage.
Iman Al dybiat, Shahsoltan Mirshahi, Meriem Belalou, Djedjiga Abdelhamid, Shahid Shah, Matti Ullah, Jeannette Soria, Marc Pocard, Massoud Mirshahi   +8 more
doaj   +1 more source

Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma

Small Science, EarlyView.
Herein, a liver‐targeted nanohybrid formulation, SGLC/DOX@AG, is developed to enhance doxorubicin delivery and reduce vascular toxicity in hepatocellular carcinoma (HCC) treatment. Incorporating an albumin–glucosamine lipid complex, the system shows potent anticancer effects and minimized side effects across in vitro, in vivo, and cancer‐on‐a‐chip ...
Hyelim Kim, Han Sol Lee, June Hong Ahn, Tae‐Wan Kwon, So‐Yeol Yoo, Donghyuk Seo, Sang Kyum Kim, Hee Ho Park, Seung‐Woo Cho, Wonhwa Lee, Jae‐Young Lee, Hong Nam Kim   +11 more
wiley   +1 more source

From Molecules to Bioaggregates: Unraveling the Photoexcitation Dynamics of Intracellularly Self‐Assembled Thiophene‐Based Fibers

Small Science, EarlyView.
Cell‐guided self‐assembly of thiophene based molecules inside living cells produces photostable, biocompatible nanofibers exhibiting J‐like excitonic coupling and stimulated emission. Integrated spectroscopic and quantum‐chemical analyses reveal unique photophysical behavior and low phototoxicity, positioning these supramolecular structures as ...
Filippo Monti, Ludovico Aloisio, Nicol Spallacci, Mattia Zangoli, Antonella Treglia, Ariel Garcìa Fleitas, Michele Guizzardi, Soraia Flammini, Matteo Moschetta, Giuseppe Maria Paternò, Francesca Di Maria, Guglielmo Lanzani   +11 more
wiley   +1 more source

Low dose aprotinin increases mortality and morbidity in coronary artery bypass surgery

Journal of Research in Medical Sciences, 2012
Background: The low dose aprotinin consistently reduces blood and transfusion requirement in adults during cardiac surgical procedures but its effectiveness in some ethnical groups were debated and controversy about its effect on mor-tality and morbidity
Feridoun Sabzi, Gholam Reza Moradi, Heidar Dadkhah, Alireza Poormotaabed, Samsam Dabiri   +4 more
doaj  

CHOICE OF THE TECHNIQUE FOR BLOOD LOSS REDUCTION IN THE RECONSTRUCTIVE ORAL SURGERY

Вестник анестезиологии и реаниматологии, 2018
Goal of the study: to define the most optimal technique for blood loss reduction during reconstructive surgeries in maxillofacilal area. Materials and methods.
A. Yu. Zaitsev, K. V. Dubrovin, V. A. Svetlov   +2 more
doaj   +1 more source

Oxytocin Enhances Demethylation Through TET Enzyme Expression in Neurons of Aged Mice: Oxytocin as a Potential Antiaging Peptide

Aging Cell, EarlyView.
DNA methylation, mitochondrial dysfunction, inflammation, and senescence interact to form a vicious cycle. Here we report that oxytocin interrupts this vicious cycle by increasing TET2 expression, inducing DNA demethylation in aged neurons and raising plasma oxytocin levels, decreasing systemic inflammation.
Yuko Maejima, Shoko Yokota, Megumi Yamachi, Shizu Hidema, Tomoyuki Ono, Shu Taira, Katsuhiko Nishimori, Heidi de Wet, Kenju Shimomura   +8 more
wiley   +1 more source