Results 81 to 90 of about 110,212 (273)

Aprotinin revisited [PDF]

Intensive Care Medicine, 2013
Stacia M, DeSantis, Christos, Lazaridis
openaire   +2 more sources

Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. [PDF]

, 2019
BACKGROUND:Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Azmoon, Pardis, Banki, Michael A, Gonias, Steven L, Kounnas, Maria Z, Mantuano, Elisabetta, Marchese, Cinzia, Pontecorvi, Paola, Zalfa, Cristina, Zampieri, Carlotta   +8 more
core   +1 more source

Trimethylamine N‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity

Experimental Physiology, EarlyView.
Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley   +1 more source

Aprotinin reduces blood loss in off-pump coronary artery bypass (OPCAB) surgery [PDF]

, 2017
Objective: Effects of aprotinin in off-pump coronary artery bypass (OPCAB) surgery have not yet been described. This study analyses hemostasiologic changes and potential benefit in OPCAB patients treated with aprotinin.
Berdat, P.A., Carrel, T.P., Eckstein, F.S., Englberger, L., Immer, F.F., Markart, P.   +5 more
core  

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. [PDF]

, 1997
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB ...
Algarté M., Aramburu J., Baeuerle P. A., Baichwal V. R., Beals C. R., Beg A. A., Bessho R., Boise L. H., Burns G. F., Chuvpilo S. D., Cockerill P. N., Cockerill P. N., Cotter T. G., Crabtree G. R., Crabtree G. R., Durand D. B., Goldfeld A. E., Gómez del Arco P., Hibi M., Ho S. N., Ho S. N., Hodge M. R., Hoey T., Izquierdo M., Jain J., Jain J., Lee H. J., Liu J., Loh C., Los M., Luo C., Luo C., Luo C., Masuda E. S., Masuda E. S., Mauri N., McCaffrey P. G., Meyer M., Minden A., Muoz C., Muoz C., Nobel C. S. I., Northrop J. P., Prieschl E. E., Radler-Pohl A., Rao A., Reisinger E. C., Rooney J. W., Ruff V. A., Schenk H., Schreck R., Schreck R., Schreiber E., Schreiber S. L., Schulze-Osthoff K., Schulze-Osthoff K., Sen C. K., Shaw J. P., Shaw K. T., Shibasaki F., Spits H., Staal F. J. T., Szabo S. J., Sánchez-Mateos P., Timmerman L. A., Traenckner E.B., Truneh A., Van Antwerp D. J., Wang C., Weiss A., Wu M., Xanthoudakis S., Yano O.   +72 more
core   +3 more sources

Downregulation of microRNA‐494 drives mitochondrial biogenesis and function in trained muscle

Experimental Physiology, EarlyView.
Abstract MicroRNAs (miRNAs) are key regulators of cellular processes, including mitochondrial function and energy metabolism. This study explores the regulation of miR‐494 in skeletal muscle and circulation, investigating its response to exercise training and an acute exercise bout, its association with metabolic disorders, and the effects of ...
Natália Pálešová, Klára Gabrišová, Jana Babulicová, Patrik Krumpolec, Zuzana Kovaničová, Tímea Kurdiová, Salvatore Modica, Christian Wolfrum, Jozef Ukropec, Barbara Ukropcová, Miroslav Baláž   +10 more
wiley   +1 more source

Correction of the Fibrinolytic Type of the Disseminated Intravascular Coagulation Syndrome in the Early Postoperative Period

Общая реаниматология, 2007
Objective: to comparatively evaluate the efficiency and safety of trasylol and aprotex used in the treatment of the fibrinolytic type of disseminated intravascular coagulation (DIC) syndrome after long abdominal operations.Materials and methods.
S. V. Sinkov, I. B. Zabolotskikh, Ye. V. Polin, L. Ye. Averyanova   +3 more
doaj   +1 more source

A lymphoma plasma membrane-associated protein with ankyrin-like properties. [PDF]

, 1986
In this study we have used several complementary techniques to isolate and characterize a 72-kD polypeptide that is tightly associated with a major mouse T-lymphoma membrane glycoprotein, gp 85 (a wheat germ agglutinin-binding protein), in a 16 S complex.
Balazovich, K, Bourguignon, LY, Suchard, SJ, Walker, G   +3 more
core  

A Molecular Basis for Stabilization of the von Hippel-Lindau (VHL) Tumor Suppressor Protein by Components of the VHL Ubiquitin Ligase [PDF]

, 2002
The multiprotein von Hippel-Lindau (VHL) tumor suppressor (CBCVHL, Cul2-Elongin BC-VHL) and SCF (Skp1-Cul1/Cdc53-F-box protein) complexes are members of structurally related families of E3 ubiquitin ligases that use a heterodimeric module composed of a ...
Brower, Christopher S., Conaway, Joan W., Conaway, Ronald C., Kamura, Takumi   +3 more
core   +2 more sources

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source