Results 131 to 140 of about 48,450 (301)
Advanced Science, EarlyView.This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai +9 more
wiley +1 more source
Aptamer-Functionalized Interface Nanopores Enable Amino Acid-Specific Peptide Detection
Single-molecule proteomics based on nanopore technology has made significant advances in recent years. However, to achieve nanopore sensing with single amino acid resolution, several bottlenecks must be tackled: controlling nanopore sizes with nanoscale ...
Haiying Hu (2960286) +11 more
core +1 more source
Aptamer-Based Folding Fluorescent Sensor for Cocaine
, 2016 We adapted in two steps a deoxyribonucleotide-based aptamer to signal the recognition of cocaine: an instability was engineered in one stem of a three-way junction that forms the cocaine-binding pocket and the resulting short stem was end labeled with a
Paloma de Prada (2982405) +2 more
core +1 more source
Advanced Science, EarlyView.A DNA‐functionalized biohybrid hydrogel is developed by integrating Cu‐mediated nucleic acid microflowers into a thermoresponsive matrix, enabling electrothermally triggered, on‐demand payload release. The platform offers spatiotemporally controllable therapeutic delivery with promising applications in precision oncology, neural regulation, and chronic
Mengqiu Sun +8 more
wiley +1 more source
, 2019 (a) UV-visible absorption spectrum of 10 μL of 1 mg•mL-1 streptavidin-coated MNPs decorated with 50 μL of 10 nM aptamer. (b) Fluorescence spectra of different concentrations (from 70 μL to 10 μL) of ssDNA2@CdTe QDs of 30 μg·mL-1 ssDNA2@CdTe QDs.
Junan Ren (3847069) +6 more
core +1 more source
Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity
Advanced Science, EarlyView.Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang +12 more
wiley +1 more source
Advanced Science, EarlyView.The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang +23 more
wiley +1 more source
Aptamer-Based Multiparameter Analysis for Molecular Profiling of Hematological Malignancies
The subtypes of hematological malignancies (HM) with minimal molecular profile differences display an extremely heterogeneous clinical course and a discrepant response to certain treatment regimens.
Tong Wang (87696) +8 more
core +1 more source
Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects
Advanced Science, EarlyView.Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu +6 more
wiley +1 more source
Fundamentals of Aptamers and Aptamers-Based Biosensors
Antibodies or enzymes have long dominated the field of sensors and analysis, based on their most effective capture capacity for many target molecules as biorecognition. Because of this, immunoassay has developed into one of the best platforms for biosensors, including clinical diagnostics.
Cem Erkmen +3 more
openaire +3 more sources