Results 121 to 130 of about 72,832 (299)

Aptamers and Cancer

Asian Pacific Journal of Cancer Biology, 2016
Oligonucleotides Aptamers are single strands of DNA and RNA with the length of 20-100 nucleotides or peptides and unique three dimensional structure that is affected by nucleotide sequence. The structure exclusively influences aptamers’ bindings with its target molecule.
Yazdanpanahi, Nasrin, Hashemi, Mehrdad, Movafagh, Abolfazl   +2 more
openaire   +4 more sources

Calculation of absolute free energy of binding for theophylline and its analogs to RNA aptamer using nonequilibrium work values

, 2007
The massively parallel computation of absolute binding free energy with a well-equilibrated system (MP-CAFEE) has been developed [H. Fujitani, Y. Tanida, M. Ito, G. Jayachandran, C. D. Snow, M. R. Shirts, E. J. Sorin, and V. S. Pande, J. Chem.
Baker, Bayly, Bennett, Berendsen, Boresch, Bustamante, Caldwell, Clore, Collin, Crooks, Crooks, Dang, Essmann, Fujitani, Gilson, Gouda, Hamelberg, Hendrix, Hermans, Hess, Hideaki Fujitani, Hoover, Jakalian, Jarzynski, Jarzynski, Jayachandran, Jenison, Jorgensen, Jorgensen, Kirkwood, Kofke, Kumar, Lindahl, Liphardt, Mahoney, Masakatsu Ito, Massoval, Mobley, Nose, Perlman, Perlman, Ritort, Shirts, Shirts, Sorin, Straatsma, Tembe, Wang, Wang, Wong, Yoshiaki Tanida, Zimmermann, Zwanzig, Åqvist   +53 more
core   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Improvement of Aptamer Affinity by Dimerization

Sensors, 2008
To increase the affinities of aptamers for their targets, we designed an aptamerdimer for thrombin and VEGF. This design is based on the avidity of the antibody, whichenables the aptamer to connect easily since it is a single-strand nucleic acid. In this
Kazunori Ikebukuro, Koji Sode, Ken-ichi Taira, Hijiri Hasegawa   +3 more
doaj  

Design of Optical Transducer for Recognition of Biomolecular Interactions between Bacterial Lipopolysaccharides and Amino Acids

Advanced Science, EarlyView.
A deep comprehension of biomolecular phenomena at interfaces is significant with their fundamental and practical importance. Our experimental and theoretical investigations reveal that specific amino acids (glutamic acid and aspartic acid) exhibit an orientational coupling with liquid crystals, which can recognize and optically report the interfacial ...
Yena Choi, Sangmin Lee, Jin‐Kang Choi, Hyunsoo Han, Yeongseon Choi, Jun‐Hyung Im, Hyein Kim, Sangmin Jeon, Minjae Lee, Chang Yun Son, Young‐Ki Kim   +10 more
wiley   +1 more source

Real-time, step-wise, electrical detection of protein molecules using dielectrophoretically aligned SWNT-film FET aptasensors [PDF]

Aptamer functionalized addressable SWNT-film arrays between cantilever electrodes were successfully developed for biosensor applications. Dielectrophoretically aligned SWNT suspended films made possible highly specific and rapid detection of target ...
An, T, HAHN, SEI KWANG, Kim, KS, Lim, G
core   +1 more source

G4‐Ligand‐Directed PROTACs Unveil DR1 as a Novel Ligand‐Co‐Binding G4‐Protein and Reshape G4‐Dependent Transcription

Advanced Science, EarlyView.
G4‐binding proteins (G4BPs) that specifically co‐bind G4s in the presence of small‐molecule ligands represent a critical but unexplored class of proteins. We introduce G4‐Ligand‐Directed PROTACs (G4L‐TACs), a chemical platform that couples G4 ligands (PDS) to E3 recruiters to selectively degrade these ligand‐co‐binding G4BPs.
Mao‐Lin Li, Shu‐Min Xu, Xin‐Chen Jiang, Le‐Tian Dai, Yu‐Tao Hu, Kai‐Bo Wang, Jia‐Heng Tan, Zhi‐Shu Huang, Shuo‐Bin Chen   +8 more
wiley   +1 more source

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

1081 CD25-specific aptamer conjugated with cytotoxic payloads shows the potential to modulate immune-suppressive environment in tumors by depleting Tregs selectively

Journal for ImmunoTherapy of Cancer, 2023
Daekyun Lee, Ju-hyung Kang, Inu Song
doaj   +1 more source

Pseudo aptamer expands aptamer’s applications [PDF]

MOJ Bioorganic & Organic Chemistry, 2018
Hengguang Li, Grace M Chavis
openaire   +1 more source