Results 121 to 130 of about 53,726 (303)
Aptamer-mediated doxorubicin delivery reduces HCC burden in 3D organoids model
, 2021 Aptamer-mediated doxorubicin delivery reduces HCC burden in 3D organoids ...
L Yuen (13400019) +10 more
core
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA
Angewandte Chemie, EarlyView.SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld +4 more
wiley +2 more sources
, 2019 An aptamer-based lateral flow test strip was developed for the simultaneous detection of Salmonella Typhimurium, Escherichia coli O157:H7, and Staphylococcus aureus.
Jiangtao Ren (2090512) +4 more
core +1 more source
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.DNA structures with short single‐strand gaps in the non‐template strand of the T7 promoter prevent transcription by T7 RNA polymerase. Contrary to intuition, however, transcriptional activity can be observed again when the size of the gap increases toward the transcription start site, thereby reducing the proportion of double‐stranded DNA in the ...
Michael W. Haydell +2 more
wiley +2 more sources
Aptamer-based therapeutic approaches to target cancer stem cells
, 2017 Aptamer-based therapeutic approaches to target cancer stem ...
G Zhou (7750079) +7 more
core
Advanced Science, EarlyView.Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu +6 more
wiley +1 more source
Matrix‐Activated Aptamer Sensors for Human Serum Analysis
Angewandte Chemie, EarlyView.The sample self‐analyzes: The predominant serum proteins, albumin and immunoglobulin G, were leveraged to activate the response of fluorescent aptamer probes within the biological matrix. The fluorescence‐anisotropy‐based sensing platform demonstrated both performance and consistency for the direct detection of small molecules in serum‐rich samples ...
Amandine Barbaroux +8 more
wiley +2 more sources