Results 111 to 120 of about 53,726 (303)
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
Nature Communications, 2019 Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell
Cheng Jin +6 more
doaj +1 more source
Aptamer-Based K+ Sensor: Process of Aptamer Transforming into G‑Quadruplex
, 2016 G-rich aptamers have been widely applied to develop various sensors for detecting proteins, small molecules, and cations, which is based on the target-induced conformational transfer from single strand to G-quadruplex.
Xiaohong Li (71964) +4 more
core +1 more source
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
DNA origami-enhanced binding of aptamers to Staphylococcus aureus cells
Biosensors and Bioelectronics: XThe combination of DNA origami nanostructures and aptamers provides a powerful technology for diagnostic assays. Here, we functionalized a DNA origami nanostructure with a Protein-A binding aptamer to target Staphylococcus aureus bacterial cells.
Yasaman Ahmadi +4 more
doaj +1 more source
Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection
Molecules, 2015 The functionalisation of microbeads with oligonucleotides has become an indispensable technique for high-throughput aptamer selection in SELEX protocols.
Lewis A. Fraser +7 more
doaj +1 more source
, 2018 Apigenin has gained interest recently among researchers as a potential chemotherapeutic agent in cancer, including colorectal cancer, due to its established antiproliferative activity in vitro.
Biswajit Mukherjee (1666519) +3 more
core +1 more source
Advanced Science, EarlyView.A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma +8 more
wiley +1 more source
Angewandte Chemie, EarlyView.DNA tile amphiphiles encode dual chemical information, directing nanostructure formation through base‐pairing and hydrophobic effects. Thermal annealing programs hierarchical assembly, with first‐formed interactions biasing the final morphology: short hydrophobic chain strands form DX‐tiles and then into stars, while long‐chain strands form SNAs and ...
Yihao Wu +3 more
wiley +2 more sources
Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy
Molecular Therapy: Nucleic Acids, 2014 Aptamers are a class of small nucleic acid ligands that are composed of RNA or single-stranded DNA oligonucleotides and have high specificity and affinity for their targets.
Hongguang Sun +5 more
doaj +1 more source