Results 101 to 110 of about 13,014 (201)

The Hoechst Dye‐Binding RNA Aptamer Recognizes Its Ligand in a Highly Dynamic Fashion

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
The Hoechst–RNA aptamer binds a tert‐butyl containing derivative of the Hoechst dye. The study presented here shows that the interactions between the RNA and ligand are highly dynamic with the ligand occupying two overlapping binding sites. The interactions are explored using NMR spectroscopy and time‐resolved fluorescence.
Natasha M. Evans, Hunter Little, Thorsten Dieckmann   +2 more
wiley   +1 more source

Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent

Biomolecules
Despite various methods for detecting and treating SARS-CoV-2, affordable and easily applicable solutions are still needed. Aptamers can potentially fill this gap. Here, we establish a workflow to identify aptamers that bind to the spike proteins of SARS-
Prasanna V. Shekar, Anuj Kumar, Nirmitee Mulgaonkar, Samneet Kashyap, Gourav Choudhir, Sandun Fernando, Sachin Rustgi   +6 more
doaj   +1 more source

Encapsulin‐Protected Immunotherapeutic Complexes: Bacteria‐Derived Nanoparticles for mRNA Delivery to Eukaryotic Cells

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Here, we introduce a biological, self‐assembling supramolecular nanoparticle designed to encapsulate eukaryotic‐expressible mRNA within an encapsulin shell via an encapsulin‐RNA adaptor peptide (ERAP). This process occurs in bacteria, and the resulting complex can deliver its mRNA into eukaryotic cells, where it is expressed.
Carlos Francisco Coffeen, Maribel Cayetano‐Cruz, Damaris Ilhuicatzi‐Alvarado, Carmen Méndez, Leticia Moreno‐Fierros, Ismael Bustos‐Jaimes   +5 more
wiley   +1 more source

Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives

Biosensors
Small molecules are highly relevant targets for detection and quantification. They are also used to diagnose and monitor the progression of disease and infectious processes and track the presence of contaminants.
Janine Kehrli, Claire Husser, Michael Ryckelynck   +2 more
doaj   +1 more source

RiboaptDB: A Comprehensive Database of Ribozymes and Aptamers

BMC Bioinformatics, 2006
Background Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that have been selected from vast populations of random sequences, through a combinatorial approach known as SELEX.
Thodima Venkata, Pirooznia Mehdi, Deng Youping   +2 more
doaj   +1 more source

Light‐Up Sensing Citrate Using a Capture‐Selected DNA Aptamer

Advanced Sensor Research
Citrate is a key metabolite and nutrient in humans. Its level is associated with many diseases from tumor growth to bone diseases. Detection of citrate has relied on its high negative charge, metal chelating properties and as an enzyme substrate. In this
Lide Gu, Yao Zhang, Deli Wang, Juewen Liu   +3 more
doaj   +1 more source

Spiegelmer Aptamers: Innovative Approach in Breast Cancer. [PDF]

Breast Cancer (Auckl)
Amiri Hezave Y, Najafi R, Amini R, Shojaeian A.   +3 more
europepmc   +1 more source

Relationships of Conformation and Function of Homo-Poly-Nucleotide Conjugated Thrombin Aptamers

KOBUNSHI RONBUNSHU, 2009
UEHARA, Shuichiro, SHIMADA, Naohiko, SAKURAGI, Mina, SAKURAI, Kazuo   +3 more
openaire   +2 more sources

In Silico Study of Anti-CD40 DNA Aptamers as Vaccine Adjuvants for Chickens. [PDF]

Int J Mol Sci
Aceves-Hernández JM, Uribe Diaz S, Omolewu A, Al-Ogaili AS, Castellanos I, Vazquez MIN, Miramontes Salinas AA, Tellez-Isaia G, Kwon YM.   +8 more
europepmc   +1 more source

Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays. [PDF]

RSC Adv
Schaudy E, Lietard J.
europepmc   +1 more source