Results 91 to 100 of about 13,014 (201)

Zinc–Adenine Metal‐Organic Frameworks for Electrochemical Detection of VCAM‐1+CD63+ Endothelial Cell‐derived Extracellular Vesicles

Electrochemical Science Advances, Volume 6, Issue 4, August 2026.
CD63‑aptamer zinc–adenine metal‐organic framework (CD63@ZnMOF) captures and concentrates extracellular vesicles (EVs) from serum before transfer to a VCAM‑1 aptamer‑modified gold electrode. This dual‐aptamer design enables specific detection of VCAM‑1+CD63+ endothelial EVs without additional redox labelling probes.
Cong Minh Nguyen, Nam‐Trung Nguyen, Hang Thu Ta   +2 more
wiley   +1 more source

Structural mechanism of insulin receptor activation by a dimeric aptamer agonist

Experimental and Molecular Medicine
Insulin binding to the insulin receptor (IR) triggers signaling pathways that regulate glucose uptake and cell growth. In previous work, we identified a DNA aptamer, A62, which partially activates the IR.
Junhong Kim, Hyeonjin Na, Si-Young Choi, Eun Ju Oh, Hyunsook Lee, Sung Ho Ryu, Na-Oh Yunn, Yunje Cho   +7 more
doaj   +1 more source

Oligonucleotides Post‐Synthetic Modifications: An Overview of Clickable Nucleoside Phosphoramidites Suitable for Solid‐Phase Synthesis

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Clickable nucleoside phosphoramidites can be incorporated into oligonucleotides via solid‐phase synthesis (SPOS), enabling rapid and site‐specific post‐functionalization using bioorthogonal reactions. This review highlights their design, synthetic accessibility, and SPOS incorporation requirements, along with the kinetics and efficiency of post ...
Sébastien Depienne, Alexandra Bristiel, Dominique Urban, Dominique Guianvarc’h   +3 more
wiley   +1 more source

Tumour‐macrophage crosstalk initiated by NFIC/METTL3 negative feedback loop via exosomal miR‐194‐5p promotes NSCLC progression

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
NFIC/METTL3 negative feedback loop in NSCLC cells suppresses exosomal miR‐194‐5p via m6A methylation; reduced miR‐194‐5p deepresses ZNF106 in macrophages, promoting M2 polarization and IL‐6 secretion; Macrophage‐derived IL‐6 activates JAK2/STAT3 in NSCLC cells to upregulate METTL3, forming a positive feedback loop.
Shu Fang, Mingyue Hao, Han Meng, Yuhang Jiang, Qiwen Li, Jiao Liang, Xiaolu He, Yi Hu, Linling Zhou, Qianrun Wang, Qiyuan Zhuo, Ji Wu, Kesong Shi   +12 more
wiley   +1 more source

Complement Inhibition in the Clinic: Are We Doing Enough to Protect Patients From Infection?

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Excessive complement activation is implicated in a broad range of diseases. Therapeutic approaches targeting the complement cascade, from pathway‐selective inhibition to terminal blockade, can effectively control disease activity. However, increasing degrees of complement inhibition are associated with a heightened susceptibility to bacterial, viral ...
Serena Bettoni, Ebba Qviberg, Edward Chaloner, Hayley Lavender, Maisem Laabei   +4 more
wiley   +1 more source

Potential Use of DNA Aptamer-Magnetic Bead Separation-PCR Assay for Salmonella Detection in Food

Journal of Food Quality and Hazards Control, 2018
Background: Salmonella is one of the most common food-borne pathogens that can cause illness. In this study, the sensitivity and the specificity of Aptamer-Magnetic bead Separation-Polymerase Chain Reaction (AMS-PCR) method were determined for Salmonella
A.N. Zifruddin, K.L. Thong
doaj  

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1300-1311, July 2026.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Co‐translational protein targeting to mitochondria in the context of co‐translational protein maturation

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
wiley   +1 more source

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science
Selective drug delivery to podocytes remains a challenge. Aptamers, nucleic acids that bind specific cells, offer a potential solution, though podocyte‐targeting aptamers have not yet been developed.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
doaj   +1 more source

The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli, Bünyamin Akgül   +1 more
wiley   +1 more source