Results 71 to 80 of about 13,014 (201)

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers

PLoS ONE, 2012
Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for time consuming trial-and-error based post-selection modifications. Locked nucleic acid (LNA) is one of the most prominent and successful nucleic acid analogues because of its remarkable properties,
Crouzier, Lucile; Dubois, Camille; Edwards, Stacey L.; Lauridsen, Lasse H.; Wengel, Jesper; Veedu, Rakesh, N.   +7 more
openaire   +9 more sources

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Identification of Amino Acids and Nucleotides Required for Interaction Between BAFF‐R and its RNA Aptamer

The FASEB Journal, 2015
Current cancer therapies such as surgery, radiation, and chemotherapy can leave residual tumor cells and have off‐target effects. Aptamers are used in a type of targeted cancer therapy that more precisely identify and attack cancer cells, while leaving unaffected cells unharmed. In B‐cell malignancies, such as non‐Hodgkins lymphoma,
Monica Lares, John Rossi
openaire   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source

Supramolecular Aptamers on Graphene Oxide for Efficient Inhibition of Thrombin Activity

Frontiers in Chemistry, 2019
Graphene oxide (GO), a two-dimensional material with a high aspect ratio and polar functional groups, can physically adsorb single-strand DNA through different types of interactions, such as hydrogen bonding and π-π stacking, making it an attractive ...
Ting-Xuan Lin, Pei-Xin Lai, Ju-Yi Mao, Ju-Yi Mao, Ju-Yi Mao, Han-Wei Chu, Binesh Unnikrishnan, Anisha Anand, Chih-Ching Huang, Chih-Ching Huang, Chih-Ching Huang   +10 more
doaj   +1 more source

Conjugated Polymers Engineered for Flexible/Stretchable Electronics

Journal of Polymer Science, EarlyView.
This review highlights glass transition temperature (Tg) as the central parameter linking molecular structure to device performance in conjugated polymers. By tuning backbone rigidity, side‐chain architecture, and dynamic bonding, Tg governs the balance between π–π stacking–enabled charge transport and mechanical compliance.
Yunchong Yang, Josh Bass, Weijia Yan, Ashwath Anand, Chunka Zhou, Jingjing Qiu   +5 more
wiley   +1 more source

Energy-based method for designing aptamers to target phosphatidylcholine

Medicine in Drug Discovery
Diverse technologies are used to design nucleic acid aptamers to achieve targeted therapeutics, engineer diagnostic tools to detect specific biomolecules associated with disease-oriented signaling pathways, and develop drug delivery systems.
Fatima Alharbi, Hamed Alsulami, Suliman AlOmar, Md. Ashrafuzzaman   +3 more
doaj   +1 more source

The tyranny of adenosine recognition among RNA aptamers to coenzyme A

BMC Evolutionary Biology, 2003
Background Understanding the diversity of interactions between RNA aptamers and nucleotide cofactors promises both to facilitate the design of new RNA enzymes that utilize these cofactors and to constrain models of RNA World evolution.
Frank Joseph, Saran Dayal, Burke Donald H   +2 more
doaj   +1 more source

Responsive nitric oxide‐releasing antibacterial materials for biofilm‐associated infections: Mechanisms, design strategies, and applications

Responsive Materials, EarlyView.
This review summarizes the recent progress in responsive NO‐releasing materials and their applications in biofilm‐associated infectious diseases. The design principles and response mechanisms are given to provide inspiration toward the future development of multi‐responsive NO‐releasing materials.
Wenyue Sun, Meiqi Li, Di Nan, Jiaqi Zhao, Yu Chen, Yao Gao, Shichen Zhang, Kirsten L. Van Landuyt, Manlin Qi   +8 more
wiley   +1 more source