Results 61 to 70 of about 13,012 (166)

Structural mechanism of insulin receptor activation by a dimeric aptamer agonist

Experimental and Molecular Medicine
Insulin binding to the insulin receptor (IR) triggers signaling pathways that regulate glucose uptake and cell growth. In previous work, we identified a DNA aptamer, A62, which partially activates the IR.
Junhong Kim, Hyeonjin Na, Si-Young Choi, Eun Ju Oh, Hyunsook Lee, Sung Ho Ryu, Na-Oh Yunn, Yunje Cho   +7 more
doaj   +1 more source

Potential Use of DNA Aptamer-Magnetic Bead Separation-PCR Assay for Salmonella Detection in Food

Journal of Food Quality and Hazards Control, 2018
Background: Salmonella is one of the most common food-borne pathogens that can cause illness. In this study, the sensitivity and the specificity of Aptamer-Magnetic bead Separation-Polymerase Chain Reaction (AMS-PCR) method were determined for Salmonella
A.N. Zifruddin, K.L. Thong
doaj  

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science
Selective drug delivery to podocytes remains a challenge. Aptamers, nucleic acids that bind specific cells, offer a potential solution, though podocyte‐targeting aptamers have not yet been developed.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
doaj   +1 more source

Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent

Biomolecules
Despite various methods for detecting and treating SARS-CoV-2, affordable and easily applicable solutions are still needed. Aptamers can potentially fill this gap. Here, we establish a workflow to identify aptamers that bind to the spike proteins of SARS-
Prasanna V. Shekar, Anuj Kumar, Nirmitee Mulgaonkar, Samneet Kashyap, Gourav Choudhir, Sandun Fernando, Sachin Rustgi   +6 more
doaj   +1 more source

Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and Perspectives

Biosensors
Small molecules are highly relevant targets for detection and quantification. They are also used to diagnose and monitor the progression of disease and infectious processes and track the presence of contaminants.
Janine Kehrli, Claire Husser, Michael Ryckelynck   +2 more
doaj   +1 more source

RiboaptDB: A Comprehensive Database of Ribozymes and Aptamers

BMC Bioinformatics, 2006
Background Catalytic RNA molecules are called ribozymes. The aptamers are DNA or RNA molecules that have been selected from vast populations of random sequences, through a combinatorial approach known as SELEX.
Thodima Venkata, Pirooznia Mehdi, Deng Youping   +2 more
doaj   +1 more source

Computational Analysis of Nucleotide Substitutions in a CD47 Aptamer: Structural and Energetic Insights

Journal of the Turkish Chemical Society, Section A: Chemistry
The Cluster of Differentiation 47 (CD47)–signal regulatory protein alpha (SIRPα) immune checkpoint is a key regulator of tumor immune evasion and a promising target in cancer immunotherapy. To overcome the limitations of monoclonal antibodies, this study
Sümeyye Altunok, Emre Can Buluz, Ehed Muhammed Aymaz   +2 more
doaj   +1 more source

Spiegelmer Aptamers: Innovative Approach in Breast Cancer. [PDF]

Breast Cancer (Auckl)
Amiri Hezave Y, Najafi R, Amini R, Shojaeian A.   +3 more
europepmc   +1 more source

In Silico Study of Anti-CD40 DNA Aptamers as Vaccine Adjuvants for Chickens. [PDF]

Int J Mol Sci
Aceves-Hernández JM, Uribe Diaz S, Omolewu A, Al-Ogaili AS, Castellanos I, Vazquez MIN, Miramontes Salinas AA, Tellez-Isaia G, Kwon YM.   +8 more
europepmc   +1 more source

Mutagenesis-based evolution enables rapid retargeting of l-aptamers for structured RNA recognition. [PDF]

RSC Chem Biol
Han X, Guilbault T, Sczepanski JT.
europepmc   +1 more source