Results 171 to 180 of about 581,942 (266)

The Marriage of Metal Nanoclusters With Reticular Frameworks: Synthetic Strategies and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of metal nanoclusters (MNCs) with reticular frameworks (RFs) has recently emerged as a powerful strategy to create composite materials with enhanced and synergistic functionalities. This review provides an overview of the synthetic strategies developed for constructing MNCs/RFs composites and their recent advances in biomedical ...
Wenfeng Liu, Qinyin Yin, Li‐Li Tan, Li Shang   +3 more
wiley   +1 more source

Molecular Crowding‐Driven RNA Condensates Enable Förster Resonance Energy Transfer‐Enhanced Small‐Molecule Sensing

Aggregate, Volume 7, Issue 2, February 2026.
This study presents a dynamic‐responsive sensing system composed of RNA aptamers and polymers for adaptive histamine sensing. Programmable RNA self‐assembly via PEG8K enables phase‐separated condensates with enhanced stability and affinity. A label‐free FRET system (ThT→HBC dyes) achieves high‐sensitive detection (15.36 nM) in complex matrices ...
Yifan Wu, Xuan Ma, Yanger Liu, Zhaoxuan Zhang, Yangzi Zhang, Wenqiang Zhang, Longjiao Zhu, Wentao Xu   +7 more
wiley   +1 more source

Proteomics reveals three molecular subtypes of Alzheimer's disease with distinct progression patterns

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) shows marked molecular heterogeneity. Defining biological subtypes may refine diagnosis and treatment. METHODS We analyzed cerebrospinal fluid (CSF) proteomics and longitudinal data from 550 participants in the Alzheimer's Disease Neuroimaging Initiative with up to 16.5 years of follow‐up. We profiled 6361
Xiao‐He Hou, Wei Zhang, Kairan Kang, Yifei Jin, Peng Ren, Linbo Wang, Zeyu Li, Yuzhu Li, Jia You, Bei Zhang, Qing Ma, for the Alzheimer's Disease Neuroimaging Initiative, Fang Xie, Jin‐Tai Yu, Jian‐Feng Feng, Wei Cheng   +15 more
wiley   +1 more source

Tissue‐Specific Extracellular Vesicles Enriched From Circulation: Exploring the Liquid Biopsy Perspective

Journal of Extracellular Biology, Volume 5, Issue 2, February 2026.
ABSTRACT Extracellular vesicles (EVs) released from tissues can be found in human biofluids. EVs reflect the phenotypic state of their cell of origin, carrying informative molecular biomarkers within and between tissues, and represent a promising target for liquid biopsy.
Biancamaria Pierri, Erez Eitan, Kenneth W. Witwer, Diane B. Re, Andrea A. Baccarelli, Haotian Wu   +5 more
wiley   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

RaptScore: a large language model-based algorithm for versatile aptamer evaluation. [PDF]

Nucleic Acids Res
Kimura-Yamazaki A, Adachi T, Nakamura S, Nakamura Y, Hamada M.   +4 more
europepmc   +1 more source

Over-Represented DNA Libraries Containing Two Hydrophobic (Het)aryl-Linked Nucleotides for Expedient Single-Round Selection of a Specific Aptamer Targeting Human Insulin Receptor

Abstract Discovery of functional nucleic acid ligands and catalytic motifs from a vast sequence space of randomized libraries is mostly based on time-consuming and demanding iterative rounds of in vitro selection.
Michal Hocek, Pablo Franco-Urquijo, Marek Ondrus, Jaroslav Kurfürst, Jana Škerlová, Irena Selicharova, Lucie Čechová, Hana Šváchová, Alena Semerádtová, Jiří Homola, Anatolij Filimoněnko, Adéla Fejfarová, Tomas Kouba   +12 more
openaire   +1 more source

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

Relationships of Conformation and Function of Homo-Poly-Nucleotide Conjugated Thrombin Aptamers

KOBUNSHI RONBUNSHU, 2009
Shuichiro UEHARA, Naohiko SHIMADA, Mina SAKURAGI, Kazuo SAKURAI   +3 more
openaire   +2 more sources

Nanobiotechnology‐Based Approaches for Uveal Melanoma Treatment

SmartMat, Volume 7, Issue 1, February 2026.
Emerging platforms for uveal melanoma combine precision drug delivery, ROS‐amplifying modalities, and nucleic acid transport to overcome ocular barriers and immunosuppressive niches. Targeted nanoparticles, virus‐like constructs, and injectable depots enable localized activation, controlled release, and gene‐level reprogramming.
Nadezhda A. Pechnikova, Ioannis Iliadis, Malamati Poimenidou, Chrysi Patsidou, Maria Zafeiriou‐Chatziefraimidou, Diamantis D. Almaliotis, Ioannis T. Tsinopoulos, Ivan V. Zelepukin, Alexey V. Yaremenko   +8 more
wiley   +1 more source