Results 181 to 190 of about 581,942 (266)

Affinity Maturation of a Fentanyl Aptamer by Motif-SELEX. [PDF]

JACS Au
Alkhamis O, Canoura J, Castro G, Byrd C, Bryant A, Yu H, Xiao Y.   +6 more
europepmc   +1 more source

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth‐Associated Proteins

Aging Cell, Volume 25, Issue 2, February 2026.
We characterized the plasma proteomic profiles of centenarians from the SWISS100 cohort, identifying 583 differentially expressed proteins compared to younger and geriatric groups. Cross‐validation with the independent datasets NECS and the TAME consortium confirmed a robust aging signature, while fractional polynomial regressions revealed a specific ...
Flavien Delhaes, Justine Falciola, Adar Hoffman, Stéphanie Carnesecchi, Stefano Cavalli, Armin von Gunten, Daniela S. Jopp, François R. Herrmann, Karl‐Heinz Krause   +8 more
wiley   +1 more source

Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier. [PDF]

Pharmaceuticals (Basel)
Yang L, Yin Y, Liu X, Guo B.
europepmc   +1 more source

Plasma Proteome Signature for Leukocyte Telomere Length and Its Link to Abdominal Aortic Aneurysm

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Shorter leukocyte telomere length (LTL) is an aging biomarker and risk factor for aging‐related diseases, including abdominal aortic aneurysm (AAA). This study aimed to identify plasma proteins causally associated with LTL and investigate their roles in linking LTL to AAA. A proteomics analysis was conducted for LTL and a polygenic risk score (
Aixin Li, Thomas R. Austin, Brian T. Steffen, Ingrid Jacobson, Jiaqi Xie, Nathan Pankratz, John A. Lane, Annette Fitzpatrick, Joshua C. Bis, Dan E. Arking, Thomas Mosley, Sanaz Sedaghat, James S. Pankow, Pamela L. Lutsey, Weihua Guan, Weihong Tang   +15 more
wiley   +1 more source

Designing molecular RNA switches with Restricted Boltzmann machines. [PDF]

Nat Commun
Fernandez-de-Cossio-Diaz J, Hardouin P, Lyonnet du Moutier FX, Di Gioacchino A, Marchand B, Ponty Y, Sargueil B, Monasson R, Cocco S.   +8 more
europepmc   +1 more source

Selection and characterization of a DNA aptamer for Patulin and its application in a label-free fluorescence assay for fruit juices. [PDF]

One Health Adv
Wang S, Liang J, Jiang H, Shen J, Wang Z, Liu J.   +5 more
europepmc   +1 more source

Ribocentre-aptamer: an integrative, structure-focused database for RNA aptamers. [PDF]

Nucleic Acids Res
Lu Z, Sun H, Fu B, Ao Y, Wang J, Chen K, Luo Y, Li L, Qiu Z, Zhao J, Sun Y, Tan Z, Liu Q, Ren Y, Guo Z, Chen X, He Y, Zhao Y, Chen Y, Li M, Peng X, Huang B, Zhu S, Huang L, Miao Z.   +24 more
europepmc   +1 more source

Versatile and Selective Biomolecule Pulldown with Combinatorial DNA‐Crosslinked Polymers

Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.
We present a programmable smart polymer system for universal, sequence‐selective bioseparation under native conditions. Polymer phase separation is achieved through combinatorial DNA crosslinking, enabling the capture of DNA, RNA, or proteins in a homogeneous solution with high pulldown efficiency and near‐zero background binding.
Sarah K. Speed, Krishna Gupta, Yu‐Hsuan Peng, Elisha Krieg   +3 more
wiley   +1 more source

Chemically modified DNA aptamers and DNAzymes for expanded functional capabilities. [PDF]

Chem Sci
Zhang C, Ma KS, Zhang Z, Lou W, Gu H, Cao Y.   +5 more
europepmc   +1 more source

Computational Analysis Uncovering Contrasts in G-Quadruplex Propensity and Aptamer Enrichment in SELEX-Derived Libraries. [PDF]

Chembiochem
Liu G, Wu TY, Kwok CK, Liu J.
europepmc   +1 more source