Results 241 to 250 of about 581,942 (266)

Emerging trends in nucleic acid and peptide aptamers in plant science research

Planta
Aptamer technology has significantly advanced the field of plant research, emerging as a tool for enhancing agricultural productivity, plant growth, and environmental monitoring.
Kannath U. Sanjay, C. M. Vinay, N. Prabhu, P. Rai   +3 more
semanticscholar   +1 more source

The application of aptamers in the repair of bone, nerve, and vascular tissues.

Journal of materials chemistry. B
Aptamers represent a distinct category of short nucleotide sequences or peptide molecules characterized by their ability to bind to specific targets with high precision. These molecules are predominantly synthesized through SELEX (Systematic Evolution of
Yu-Wei Hsu, Le Ma, Ye Tang, Mengen Li, Chengkai Zhou, Yan Geng, Chenxi Zhang, Tianbing Wang, Wei Guo, Ming Li, Yanhua Wang   +10 more
semanticscholar   +1 more source

Structural optimization and anti-allergic activity of nucleotide aptamers target to Cε3-Cε4

Biochemical Pharmacology, 2019
Nucleic acid aptamers have shown a broad application prospect in basic research, clinical diagnosis and treatment, new drug development and various other fields. We have screened the DNA aptamer A1 and A2 target at Cε3-Cε4 with high affinity and specificity, another aptamer A8, no affinity with Cε3-Cε4 protein, was as a negative control in this study ...
Yanlei Yang, Lijian Zhao, Su Zhang, Zhenzhen Xu, Lifang Hao, Zhe Cui, Kewei Bi, Yanfen Zhang, Zhongcheng Liu   +8 more
openaire   +2 more sources

Wash-Free and High-Contrast Imaging of Single-Nucleotide Variation in Single Cells Using Transcription-Amplified Light-Up RNA Aptamer

Analytical Chemistry, 2023
Single-nucleotide variation (SNV) imaging can indicate cellular heterogeneity and spatial pattern, but it remains challenging to produce high-gain signal while also yielding single-nucleotide resolution. Herein, we developed a light-up strategy for visualizing SNVs based on transcription amplification, enabling wash-free and high-contrast imaging of ...
Xuhan Xia, Feng Li, Yong Zhang, Yulin Zhu, Sishuo Song, Guiping He, Jiaqi Zhang, Qiang He, Ruijie Deng   +8 more
openaire   +2 more sources

Aptamers as therapeutic targets: prospects and progress in the treatment of cancers.

Nucleosides, Nucleotides & Nucleic Acids
Contemporary cancer treatments encompass diverse strategies like surgery, chemotherapy, radiation, immunotherapy, and targeted therapies, aiming for effective cancer cell control with minimal impact on healthy tissues.
Yash Sansare, Priyatharcini Kejamurthy, Suramya Singh, Aryan Ayush, Koustubhi Khani, K. R. Ramya Devi   +5 more
semanticscholar   +1 more source

Fluorescence Anisotropy Analysis for Mapping Aptamer–Protein Interaction at the Single Nucleotide Level

Journal of the American Chemical Society, 2011
Structural characterization of aptamer-protein interactions is challenging and limited despite the tremendous applications of aptamers. Here we for the first time report a fluorescence anisotropy (FA) approach for mapping the interaction of an aptamer and its protein target at the single nucleotide level.
Dapeng, Zhang, Meiling, Lu, Hailin, Wang
openaire   +2 more sources

Variety of Nucleotide Polymerase Mutants Aiming to Synthesize Modified RNA

ChemBioChem, 2021
Significant efforts have been made to develop therapeutic RNA aptamers that exploit synthetic RNA to capture target molecules. However, ensuring RNA aptamers are resistant against intrinsic nucleases remains an issue and restricts their use as ...
Sana Ohashi, Fumitaka Hashiya, H. Abe
semanticscholar   +1 more source

In silico screening of ssDNA aptamer against Escherichia coli O157:H7: A machine learning and the Pseudo K-tuple nucleotide composition based approach

Computational Biology and Chemistry, 2021
This study was planned to in silico screening of ssDNA aptamer against Escherichia coli O157:H7 by combination of machine learning and the PseKNC approach. For this, firstly a total numbers of 47 validated ssDNA aptamers as well as 498 random DNA sequences were considered as positive and negative training data respectively. The sequences then converted
Mokhtar, Nosrati, Jafar, Amani
openaire   +2 more sources

RNA aptamers: promising tools in synthetic biology

at - Automatisierungstechnik
Synthetic elements made entirely of RNA are suitable as regulatory elements in genetically modified systems and as biosensors. Such RNA aptamers are highly structured nucleotide sequences capable of specifically binding a target molecule.
Daniel Kelvin, B. Suess
semanticscholar   +1 more source

In vitro selection of human cerebrospinal fluid-specific aptamers using clinical samples.

Rhinology
BACKGROUND Cerebrospinal fluid (CSF) leaks may occur due to numerous etiologies and are associated with severe morbidity. Currently in the U.S., confirming the presence of a CSF leak requires protein electrophoresis testing, oftentimes involving ...
A. Abiri, X. Chen, B. Latifi, F. P. K. Hsu, A. Lupták, M. Khine, E. C. Kuan   +6 more
semanticscholar   +1 more source