Results 51 to 60 of about 29,754 (236)
DNA Aptamers in the Diagnosis and Treatment of Human Diseases
Molecules, 2015 Aptamers have a promising role in the field of life science and have been extensively researched for application as analytical tools, therapeutic agents and as vehicles for targeted drug delivery.
Qinchang Zhu, Ge Liu, Masaaki Kai
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Aptamers as Theragnostic Tools in Prostate Cancer
Biomolecules, 2022 Despite of the capacity that several drugs have for specific inhibition of the androgen receptor (AR), in most cases, PCa progresses to an androgen-independent stage.
Carlos David Cruz-Hernández +11 more
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Multi‐Scale Interface Engineering of MXenes for Multifunctional Sensory Systems
Advanced Functional Materials, EarlyView.MXenes, as two‐dimensional transition metal carbides and nitrides, demonstrate remarkable capabilities for multifunctional sensing applications. This review systematically examines multi‐scale interface engineering approaches that enhance sensing performance, enable diverse detection functionalities, and improve system‐level compatibility in MXene ...
Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
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The Analyst, 2016 Nucleic acid aptamers are promising alternatives to antibodies in analytics.
Ilgu, Muslum, Nilsen-Hamilton, Marit
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Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives
Advanced Materials, EarlyView.Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi +4 more
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Advanced ScienceThe interaction between SCAF4 and RNA polymerase II (POLR2A) is crucial for proper mRNA termination, with its dysregulation leading to truncated mRNAs and nonfunctional proteins, impairing cellular growth.
Liyan Fei +13 more
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Aptamer-iRNAs as Therapeutics for Cancer Treatment
Pharmaceuticals, 2018 Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize their targets with high affinity and specificity due to their complex tertiary structure.
Mario M. Soldevilla +3 more
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Aptamers as therapeutics [PDF]
Nature Reviews Drug Discovery, 2010 Nucleic acid aptamers can be selected from pools of random-sequence oligonucleotides to bind a wide range of biomedically relevant proteins with affinities and specificities that are comparable to antibodies. Aptamers exhibit significant advantages relative to protein therapeutics in terms of size, synthetic accessibility and modification by medicinal ...
Keefe, Anthony D. +2 more
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Assembling a True “Olympic Gel” From over 16 000 Combinatorial DNA Rings
Advanced Materials, EarlyView.Olympic gels are an elusive class of soft matter, consisting of molecular networks held together purely by mechanically interlocked rings. Their topological structure promises unique properties and functions, but their synthesis has proven notoriously difficult.
Sarah K. Speed +9 more
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Advanced Materials Interfaces, EarlyView.ABSTRACT Capturing proteins is easy since their amphiphilic nature allows them to bind to almost any surface. Because of this, releasing them is challenging since various interactions need to be considered for this. We present a simple method to reversibly adsorb proteins on stabilized electrodes.
Erik J. Postma +3 more
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