Results 71 to 80 of about 796 (185)

Application of quality-by-design approach in the analytical method development for quantification of sugars in sugarcane honey by reversed-phase liquid chromatography [PDF]

, 2020
Produced in Madeira Island from regional sugarcane cultivars through a traditional manufacturing and storage process, sugarcane honey (SCH) is a black syrup recognized by its excellent quality.
Câmara, José S., Nunes, Fernando M., Perestrelo, Rosa, Silva, Catarina L., Silva, Pedro   +4 more
core   +1 more source

Green Analytical Stability Indicating UHPLC Method for the Quantification of Related Impurities in Vonoprazan Formulation Applying Analytical Quality by Design

SEPARATION SCIENCE PLUS, Volume 8, Issue 4, April 2025.
ABSTRACT Vonoprazan is an innovative potassium competitive acid blocker and has emerged as an effective alternative to proton pump inhibitors for the treatment of acid‐related disorders. High‐performance liquid chromatography was performed using a Symmetry C18 column (150 mm × 4.6 mm ID, 3.0 µm) with a mobile phase flow rate of 1.0 mL/min. Mobile phase
Ashwinkumar Matta, Raja Sundararajan
wiley   +1 more source

DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF BENIDIPINE HYDROCHLORIDE BY USING QUALITY BY DESIGN (QbD) APPROACH [PDF]

, 2018
Objective: To develop a simple, rapid, accurate, robust and inexpensive spectrophotometric method for the estimation of benidipine hydrochloride by using quality by design (QbD)†approach.Methods: A UV spectrophotometric method was developed on Shimadzu
Bishnoi, Ram Singh, Jain, C. P., Kumar, Manish, Shukla, Ajay Kumar   +3 more
core   +3 more sources

Potency Assay Variability Estimation in Practice

Pharmaceutical Statistics, Volume 24, Issue 1, January/February 2025.
Abstract During the drug development process, testing potency plays an important role in the quality assessment required for the manufacturing and marketing of biologics. Due to multiple operational and biological factors, higher variability is usually observed in bioassays compared with physicochemical methods.
Hang Li, Tomasz M. Witkos, Scott Umlauf, Christopher Thompson   +3 more
wiley   +1 more source

Isolation, Identification, and Characterization of Forced Degradation Products of Bosentan by Using Advanced Analytical Techniques

SEPARATION SCIENCE PLUS, Volume 7, Issue 10, October 2024.
ABSTRACT The present study explains the degradation behavior of bosentan (BOS), active pharmaceutical ingredient (API) (BOS monohydrate), a Food and Drug Administration (FDA)–approved drug used for the treatment of chronic heart failure, subarachnoid hemorrhage, and Raynaud's syndrome pulmonary hypertension. The stress study was performed under various
Rajesh Kanagaddi, Satya Sree Nannapaneni, Jayaprakash Kanijam Raghupathi, Naresh Kumar Katari, Suresh Salakolusu, J. N. S. R. C. Murty, Mahesh Ranga, Muralidharan Kaliyaperumal   +7 more
wiley   +1 more source

A Boundary Term for the Gravitational Action with Null Boundaries

, 2016
Constructing a well-posed variational principle is a non-trivial issue in general relativity. For spacelike and timelike boundaries, one knows that the addition of the Gibbons-Hawking-York (GHY) counter-term will make the variational principle well ...
Chakraborty, Sumanta, Majhi, Bibhas Ranjan, Padmanabhan, T., Parattu, Krishnamohan   +3 more
core   +1 more source

Selectivity study on thermochemical conversion of fruit residues (Plums) to platform chemicals (HMF) [PDF]

, 2023
5-hydroxymethylfurfural (HMF) is one of the versatile platform compounds derived from the dehydration of carbohydrates originating from biomass. However, the non-selective production of HMF from carbohydrates and its subsequent separation from the ...
Bebizuh, Dawit Firemichael
core  

New Variables for Classical and Quantum Gravity in all Dimensions II. Lagrangian Analysis

, 2013
We rederive the results of our companion paper, for matching spacetime and internal signature, by applying in detail the Dirac algorithm to the Palatini action.
A Thurn, Alexandrov S, Anishetty R, Ashtekar A, Ashtekar A, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Bodendorfer N, Dirac P A M, Freidel L, Freidel L, Giesel K, Henneaux M, Livine E R, N Bodendorfer, Peldan P, Rovelli C, T Thiemann, Thiemann T   +21 more
core   +1 more source

Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems [PDF]

, 2018
The current research work encompasses the development, characterization, and evaluation of self-assembled phospholipidic nano-mixed miceller system (SPNMS) of a poorly soluble BCS Class IV xanthone bioactive, mangiferin (Mgf) functionalized with co ...
Gaspar, Balan Louis, Katare, O P, Khurana, Rajneet Kaur, Singh, Bhupinder, Singh, Kamalinder K, Welsby, Gail   +5 more
core   +2 more sources

Environmental benign analytical quality by design and UPLC method development for Betamethasone and Calcipotriene in ointment

Journal of Taibah University for Science, 2021
The present study aimed to estimate Betamethasone and Calcipotriene in bulk and ointment formulation using a validated UPLC method by applying analytical quality design with green analytical chemistry principles.
Kanaka Parvathi Kannaiah, Abimanyu Sugumaran   +1 more
doaj   +1 more source