Results 191 to 200 of about 18,317 (228)
AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis [PDF]
Cells, 2019 Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells and glia limitants have been proposed to play a significant role in cerebrospinal fluid (CSF) production and homeostasis. However, the specific contribution of each water channel to these functions remains unknown, being a subject ...
JOSÉ Luis Trillo-Contreras +2 more
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Neuromyelitis Optica-AQP4: An Update
Current Rheumatology Reports, 2011Devic disease (neuromyelitis optica [NMO]) is an idiopathic inflammatory demyelinating and necrotizing disease characterized by optic neuritis and transverse myelitis, either simultaneously or in isolation. NMO is often idiopathic but may also be associated with systemic autoimmune disease. The prognosis of NMO is severe, especially in those with early
Emilio, Benavente, Sergio, Paira
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Deletional tolerance prevents AQP4‐directed autoimmunity in mice [PDF]
European Journal of Immunology, 2017 Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system (CNS) mediated by antibodies to the water channel protein AQP4 expressed in astrocytes. The contribution of AQP4‐specific T cells to the class switch recombination of pathogenic AQP4‐specific antibodies and the inflammation of the blood–brain barrier is incompletely ...
Benjamin Knier +2 more
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Cancer Research, 2023
Abstract Brain edema is a complication of radiation used to treat brain metastasis (BM) in which the brain parenchyma accumulates fluid and ions, often leading to the suspension of systemic anticancer treatment. While brain edema is often attributed to disruption of the Blood Brain Barrier (BBB), RTx induces cytotoxic-edema, a premorbid ...
Maria J. Contreras-Zarate +6 more
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Abstract Brain edema is a complication of radiation used to treat brain metastasis (BM) in which the brain parenchyma accumulates fluid and ions, often leading to the suspension of systemic anticancer treatment. While brain edema is often attributed to disruption of the Blood Brain Barrier (BBB), RTx induces cytotoxic-edema, a premorbid ...
Maria J. Contreras-Zarate +6 more
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Journal of Clinical Neuroscience, 2020
The spatial and temporal distribution of aquaporin-4 (AQP4) expression in rat brain following brain trauma and AQP4-siRNA treatment, as well as corresponding pathological changes, were studied to explore the mechanism underlying the effect of AQP4-siRNA treatment on traumatic brain injury (TBI). The rats in the sham operation group had normal structure,
Jianqiang Chen
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The spatial and temporal distribution of aquaporin-4 (AQP4) expression in rat brain following brain trauma and AQP4-siRNA treatment, as well as corresponding pathological changes, were studied to explore the mechanism underlying the effect of AQP4-siRNA treatment on traumatic brain injury (TBI). The rats in the sham operation group had normal structure,
Jianqiang Chen
exaly +3 more sources
Chimeric AQP4-based immunosorbent for highly-specific removal of AQP4-IgG from blood
Journal of Chromatography AAnti-aquaporin-4 autoantibodies (AQP4-IgG) are implicated in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), and their removal from the blood circulation is considered to be an effective method for acute treatment. An ideal extracorporeal AQP4-IgG removal system should have high specificity, which means that it can selectively ...
Xiaofei Wang, Fangling Ji, Lingyun Jia
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Expression of AQP1 and AQP4 in paediatric brain tumours
Journal of Clinical Neuroscience, 2011Aquaporins (AQP) are water-channel proteins with roles in tumour cell migration, angiogenesis, cerebral oedema and cell-cell adhesion. We aimed to determine the expression of AQP1 and AQP4 in paediatric brain tumours. Twenty tumour bank specimens were subject to Western blot analysis and quantitative polymerase chain reaction (PCR) to determine the ...
Dongwei, Wang, Brian K, Owler
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Regulation and Function of AQP4 in the Central Nervous System
Neurochemical Research, 2015Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation.
Assentoft, Mette +2 more
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Abnormalities in the pattern of AQP4 immunoreactivity
The FASEB Journal, 2006With regard to the paper by Meshorer et al. (1), the authors address an interesting question concerning long-lasting consequences of cholinergic imbalance. To address this question, the authors used transgenic mice (TgS) with a neuronal overexpression of synaptic acetylcholinesterase, in which they observed a significant decrease in the baseline of the
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Mechanisms underlying AQP4 accumulation in astrocyte endfeet
Glia, 2015The brain–blood interface holds the key to our understanding of how cerebral blood flow is regulated and how water and solutes are exchanged between blood and brain. The highly specialized astrocytic membranes that enwrap brain microvessels are salient constituents of the brain‐blood interface.
Laura Maria Azzurra, Camassa +7 more
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