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Multiple Sclerosis and Related Disorders
NMOSD is a rare autoimmune disorder with variable clinical presentations depending on AQP4-IgG serostatus. While AQP4-IgG-positive NMOSD is well described, data on seronegative cases, especially in Latin America, remain limited.To characterize the demographic and clinical features of NMOSD in Latin America, comparing AQP4-IgG-positive and AQP4-IgG ...
Ricardo Alonso +33 more
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NMOSD is a rare autoimmune disorder with variable clinical presentations depending on AQP4-IgG serostatus. While AQP4-IgG-positive NMOSD is well described, data on seronegative cases, especially in Latin America, remain limited.To characterize the demographic and clinical features of NMOSD in Latin America, comparing AQP4-IgG-positive and AQP4-IgG ...
Ricardo Alonso +33 more
openaire +2 more sources
Biochemistry
AQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment. We designed two fusion proteins, AQP4-DARPin1 and AQP4-DARPin2, comprising the complete antigenic epitopes of aquaporin-4 (AQP4) and the constant region of the ...
Xiaofei Wang +5 more
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AQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment. We designed two fusion proteins, AQP4-DARPin1 and AQP4-DARPin2, comprising the complete antigenic epitopes of aquaporin-4 (AQP4) and the constant region of the ...
Xiaofei Wang +5 more
openaire +2 more sources
Neurology, 2013
Detecting aquaporin-4 (AQP4) antibody is a key laboratory finding in the diagnosis of neuromyelitis optica (NMO) or its limited forms, known as NMO spectrum disorders (NMOSD).1,2 It is important to differentiate NMO from multiple sclerosis (MS), as drugs approved for MS (interferon-β, natalizumab, and fingolimod) are ineffective in NMO/NMOSD.
Kazuo, Fujihara, Douglas Kazutoshi, Sato
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Detecting aquaporin-4 (AQP4) antibody is a key laboratory finding in the diagnosis of neuromyelitis optica (NMO) or its limited forms, known as NMO spectrum disorders (NMOSD).1,2 It is important to differentiate NMO from multiple sclerosis (MS), as drugs approved for MS (interferon-β, natalizumab, and fingolimod) are ineffective in NMO/NMOSD.
Kazuo, Fujihara, Douglas Kazutoshi, Sato
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[AQP4 regulation for cerebral edema].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2013Water balance is one of the basic regulation mechanisms of homeostasis. There are 13 subtypes of aquaporins in mammals (AQP0-AQP12). In neural system, the AQP4 is mainly distributed in astrocytes. Phosphorylation and expression regulation of AQP4 is involved in the formation of brain edema, particularly in the clearance of vasogenic edema and the ...
Min, Li +3 more
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Ravulizumab effective in AQP4+ NMOSD
Medicom Conference Report AAN 2023, 2023openaire +1 more source