Results 221 to 230 of about 24,501 (255)

Regulation of Aquaporin-4 Expression in the Central Nervous System Investigated Using M23-AQP4 Null Mouse [PDF]

Glia, 2021
In astrocytes, unknown mechanisms regulate the expression of M1 and M23 isoforms of water channel aquaporin-4 (M1-AQP4 and M23-AQP4). The ratio between these two isoforms controls the AQP4 assembly state in the plasma membrane known as orthogonal arrays ...
Francesco Pisani, Laura Simone, Grazia Paola Nicchia   +2 more
exaly   +2 more sources

B Cells Orchestrate Tolerance to the Neuromyelitis Optica Autoantigen AQP4 [PDF]

Nature
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen1. The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP42.
Bernhard Hemmer, Dirk H Busch, Doron Merkler   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Neuromyelitis Optica-AQP4: An Update

Current Rheumatology Reports, 2011
Devic disease (neuromyelitis optica [NMO]) is an idiopathic inflammatory demyelinating and necrotizing disease characterized by optic neuritis and transverse myelitis, either simultaneously or in isolation. NMO is often idiopathic but may also be associated with systemic autoimmune disease. The prognosis of NMO is severe, especially in those with early
Emilio, Benavente, Sergio, Paira
openaire   +2 more sources

Abstract P1-10-09: AQP4 inhibition prevents cytotoxic edema of AQP4+ astrocytes but promotes tumor growth of AQP4+ breast cancer brain metastasis

Cancer Research, 2023
Abstract Brain edema is a complication of radiation used to treat brain metastasis (BM) in which the brain parenchyma accumulates fluid and ions, often leading to the suspension of systemic anticancer treatment. While brain edema is often attributed to disruption of the Blood Brain Barrier (BBB), RTx induces cytotoxic-edema, a premorbid ...
Maria J. Contreras-Zarate, Karen ALvarez-Eraso, Nicole Tsuji, Peter Kabos, D.Ryan Ormond, Sana Karam, Diana Cittelly   +6 more
openaire   +1 more source

NFAT5-Dependent Expression of AQP4 in Astrocytes

Cellular and Molecular Neurobiology, 2012
The maintenance of water homeostasis under pathological conditions is mediated by the aquaporin-4 (AQP4) channel in astrocytes. To clarify the transcriptional regulation for AQP4 under conditions of astrocytic swelling, we examined the role of nuclear factor of activated T cells 5 (NFAT5).
Min-Hee, Yi, Young Sook, Lee, Joon Won, Kang, Soo Jin, Kim, Sang-Ha, Oh, Yong Min, Kim, Young Ho, Lee, Sang Do, Lee, Dong Woon, Kim   +8 more
openaire   +2 more sources

AQP4-siRNA Alleviates Traumatic Brain Edema by Altering Post-Traumatic AQP4 Polarity Reversal in TBI Rats

Journal of Clinical Neuroscience, 2020
The spatial and temporal distribution of aquaporin-4 (AQP4) expression in rat brain following brain trauma and AQP4-siRNA treatment, as well as corresponding pathological changes, were studied to explore the mechanism underlying the effect of AQP4-siRNA treatment on traumatic brain injury (TBI). The rats in the sham operation group had normal structure,
Jianqiang Chen, Li Ai
exaly   +3 more sources

Chimeric AQP4-based immunosorbent for highly-specific removal of AQP4-IgG from blood

Journal of Chromatography A
Anti-aquaporin-4 autoantibodies (AQP4-IgG) are implicated in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), and their removal from the blood circulation is considered to be an effective method for acute treatment. An ideal extracorporeal AQP4-IgG removal system should have high specificity, which means that it can selectively ...
Xiaofei Wang, Fangling Ji, Lingyun Jia
openaire   +2 more sources

Abnormalities in the pattern of AQP4 immunoreactivity

The FASEB Journal, 2006
With regard to the paper by Meshorer et al. (1), the authors address an interesting question concerning long-lasting consequences of cholinergic imbalance. To address this question, the authors used transgenic mice (TgS) with a neuronal overexpression of synaptic acetylcholinesterase, in which they observed a significant decrease in the baseline of the
openaire   +1 more source

Mechanisms underlying AQP4 accumulation in astrocyte endfeet

Glia, 2015
The brain–blood interface holds the key to our understanding of how cerebral blood flow is regulated and how water and solutes are exchanged between blood and brain. The highly specialized astrocytic membranes that enwrap brain microvessels are salient constituents of the brain‐blood interface.
Laura Maria Azzurra, Camassa, Lisa K, Lunde, Eystein H, Hoddevik, Maria, Stensland, Henning B, Boldt, Gustavo A, De Souza, Ole P, Ottersen, Mahmood, Amiry-Moghaddam   +7 more
openaire   +2 more sources

Expression of AQP1 and AQP4 in paediatric brain tumours

Journal of Clinical Neuroscience, 2011
Aquaporins (AQP) are water-channel proteins with roles in tumour cell migration, angiogenesis, cerebral oedema and cell-cell adhesion. We aimed to determine the expression of AQP1 and AQP4 in paediatric brain tumours. Twenty tumour bank specimens were subject to Western blot analysis and quantitative polymerase chain reaction (PCR) to determine the ...
Dongwei, Wang, Brian K, Owler
openaire   +2 more sources