Results 91 to 100 of about 1,989 (206)

Trypanosomatid Aquaporins: Roles in Physiology and Drug Response

Diseases, 2013
In the class Kinetoplastida, we find an order of parasitic protozoans classified as Trypanosomatids. Three major pathogens form part of this order, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania, which are responsible for disease and fatalities in
Goutam Mandal, Jose F. Orta, Mansi Sharma, Rita Mukhopadhyay   +3 more
doaj   +1 more source

Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei.

PLoS Neglected Tropical Diseases, 2020
Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel ...
Juan F Quintana, Juan Bueren-Calabuig, Fabio Zuccotto, Harry P de Koning, David Horn, Mark C Field   +5 more
doaj   +1 more source

Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. METHODOLOGY/PRINCIPAL FINDINGS:Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony ...
Rubens Monte-Neto, Marie-Claude N Laffitte, Philippe Leprohon, Priscila Reis, Frédéric Frézard, Marc Ouellette   +5 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Freeze‐tolerant frogs accumulate cryoprotectants using photoperiod: A potential ecological trap

Journal of Animal Ecology, Volume 94, Issue 11, Page 2255-2266, November 2025.
Climate change is disrupting the reliability of photoperiod as a cue signalling seasonal changes in temperature. We show that gray treefrogs under a late‐season photoperiod accumulated large reserves of ‘antifreeze’ and exhibited greater cold tolerance.
Troy C. Neptune, Diana C. Koester, Michael F. Benard   +2 more
wiley   +1 more source

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background [PDF]

, 2012
The evolution of drug-resistance in pathogens is a major global health threat. Elucidating the molecular basis of pathogen drug-resistance has been the focus of many studies but rarely is it known whether a drug-resistance mechanism identified is ...
Sylke Müller, Hideo Imamura (62469), Dujardin, J., Khanal, Basudha, Brunker, K., Brunker, Kirstyn, Kirstyn Brunker (181178), Graham H. Coombs (164011), Suman Rijal (181185), Imamura, Hideo, Jean-Claude Dujardin, M\ufcller, Sylke, Dujardin, Jean-Claude, Dujardin, J. C., Coombs, G. H., Muller, S., Jean-Claude Dujardin (56958), Decuypere, S., Coombs, G.H., Vanaerschot, M., Decuypere, Saskia, Coombs, Graham H, Rijal, S., Manu Vanaerschot, Sylke Müller (37476), Basudha Khanal, Khanal, B., Hideo Imamura, Kirstyn Brunker, Müller, Sylke, Coombs, Graham H., Vanaerschot, Manu, Imamura, H., Rijal, Suman, Saskia Decuypere, Basudha Khanal (181181), Saskia Decuypere (181176), Manu Vanaerschot (109210), Suman Rijal, Graham H Coombs   +39 more
core   +1 more source

Pan‐Cancer Analysis of the Prognostic and Immunological Role of AQP9: Friend or Foe?

Cancer Nexus, Volume 1, Issue 3, October 2025.
ABSTRACT Purpose The aquaporin‐9 (AQP9) has been implicated in tumorigenesis, but its pan‐cancer prognostic and immunology remain poorly understood. Therefore, we explored the role of AQP9 in pan‐cancer. Methods We systematically analyzed the expression of AQP9 across human cancers using multi‐omics data from The Cancer Genome Atlas (TCGA), Genotype ...
Rui Li, Junwei Zhang, Xuan Fang, Huaicun Liu, Yueqi Wang, Junxiao Jia, Yu Song, Weiguang Zhang, Junxiu Liu   +8 more
wiley   +1 more source

Expression of aquaglyceroporin in spermatozoa of two marine fish (sparus aurata and dicentrarchus labrax) [PDF]

, 2008
The aquaporins (AQPs) are a family of small, hydrophobic, integral membrane proteins that allow rapid water transport across the cell membrane. Relatively few reports about AQPs in non-mammalian vertebrates exist.
VILELLA, Sebastiano, SCHIAVONE, Roberta, ZILLI, Loredana, STORELLI, Carlo   +3 more
core  

Diabetic Kidney Disease‐Associated Pathological Angiogenesis: The Role of Aquaporin‐1

Journal of Diabetes, Volume 17, Issue 10, October 2025.
Hyperglycemia upregulates AQP1 expression in renal endothelial cells, promoting abnormal angiogenesis. Structurally and functionally immature vessels lead to glomerular capillary leakage, proteinuria, and progressive renal injury. Targeting AQP1 may attenuate abnormal angiogenesis in DKD and slow disease progression.
Fengyi Zhang, Jiayi Zhang, Xin Wang, Yaxin Chen, Ziyang Cheng, Jingjing Pan, Yufeng Zhang, Yujie Li, Wenbo Wang, Linhua Zhao   +9 more
wiley   +1 more source

Dynamic Regulation of Aquaglyceroporin Expression in Erythrocyte Cultures from Cold- and Warm-Acclimated Cope\u27s Gray Treefrog, Hyla Chrysoscelis [PDF]

, 2011
Cope\u27s gray treefrog, Hyla chrysoscelis,is a freeze-tolerant anuran which accumulates and distributes glycerol as a cryoprotectant before freezing.
Puccetti, Matthew V., Carissa M. Krane, Frisbie, James, Matthew V. Puccetti, Krane, Carissa M., Venkateshwar Mutyam, James Frisbie, David L. Goldstein, Mutyam, Venkateshwar, Goldstein, David L.   +9 more
core   +1 more source