Results 131 to 140 of about 38,738 (164)

Inhibition of Aquaporin 4 by antiepileptic drugs

Bioorganic & Medicinal Chemistry, 2009
The potential of antiepileptic drugs (AEDs) to inhibit the water transport properties of aquaporin 4 (AQP4) was investigated using a combination of in silico and in vitro screening methods. Virtual docking studies on 14 AEDs indicated a range of docking energies that spanned approximately 40 kcal/mol, where the most stabilized energies were consistent ...
Vincent J, Huber, Mika, Tsujita, Ingrid L, Kwee, Tsutomu, Nakada   +3 more
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Identification of arylsulfonamides as Aquaporin 4 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2007
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
Vincent J, Huber, Mika, Tsujita, Maya, Yamazaki, Kenji, Sakimura, Tsutomu, Nakada   +4 more
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Aquaporin-4, homeostasis, and neurologic disease

Neurology, 2007
Aquaporins constitute a family of water channels that regulate the transport of water in essentially all organs, including the kidney, gastrointestinal tract, secretory glands, inner ear, nervous system, and muscle.1–3 Because of his seminal discovery of aquaporins as the long-sought water channels,1 Peter Agre of Johns Hopkins University was awarded ...
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Hydrocephalus and Aquaporins: The Role of Aquaporin-4

2011
Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
A S, Filippidis, M Y S, Kalani, H L, Rekate   +2 more
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Heterotetrameric Composition of Aquaporin-4 Water Channels

Biochemistry, 1999
Aquaporin (AQP) water channel proteins are tetrameric assemblies of individually active approximately 30 kDa subunits. AQP4 is the predominant water channel protein in brain, but immunoblotting of native tissues has previously yielded multiple poorly resolved bands.
Agre, Peter, Nielsen, S, Christensen, B. M., Neely, JD   +3 more
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Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

Multiple Sclerosis Journal, 2009
Background Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease.
T, Matsushita, N, Isobe, T, Matsuoka, N, Shi, Y, Kawano, X M, Wu, T, Yoshiura, Y, Nakao, T, Ishizu, J I, Kira   +9 more
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Expression and localization of aquaporin-4 in sensory ganglia

Biochemical and Biophysical Research Communications, 2014
Aquaporin-4 (AQP4) is a water channel protein that is predominantly expressed in astrocytes in the CNS. The rapid water flux through AQP4 may contribute to electrolyte/water homeostasis and may support neuronal activities in the CNS. On the other hand, little is known about the expression of AQP4 in the peripheral nervous system (PNS).
Jungo, Kato, Yoshiki, Takai, Mariko Kato, Hayashi, Yasuhiro, Kato, Manami, Tanaka, Yoshiro, Sohma, Yoichiro, Abe, Masato, Yasui   +7 more
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Genetic analysis of aquaporin-4 in neuromyelitis optica

Neurology, 2011
Autoantibodies to aquaporin-4 (AQP4) are specific and pathogenic for neuromyelitis optica (NMO). Therefore, we evaluated whether AQP4 single-nucleotide polymorphisms (SNPs) are associated with susceptibility to NMO or whether mutations that potentially alter AQP4 structure or expression are present in some patients.We genotyped 8 AQP4 SNPs chosen based
M, Matiello, J L, Schaefer-Klein, D D, Hebrink, D J, Kingsbury, E J, Atkinson, B G, Weinshenker   +5 more
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The Potential Roles of Aquaporin 4 in Alzheimer’s Disease

Molecular Neurobiology, 2015
Aquaporin 4 (AQP4) is the major water channel expressed in the central nervous system (CNS), and it is primarily expressed in astrocytes. It has been studied in various brain pathological conditions. However, the potential for AQP4 to influence Alzheimer's disease (AD) is still unclear. Research regarding AQP4 functions related to AD can be traced back
Yu-Long, Lan, Jie, Zhao, Tonghui, Ma, Shao, Li   +3 more
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Aquaporin 4 and hydrocephalus

Journal of Neurosurgery: Pediatrics, 2006
James P. McAllister, Janet M. Miller
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