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Aquaporin‐4 and epilepsy [PDF]
Glia, 2012 AbstractRecent studies have implicated glial cells in modulation of synaptic transmission, so it is plausible that glial cells may have a functional role in the hyperexcitability characteristic of epilepsy. Indeed, alterations in distinct astrocyte membrane channels, receptors, and transporters have all been associated with the epileptic state.
Ole Petter Ottersen +2 more
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Aquaporin-4 and Alzheimer’s Disease
Journal of Alzheimer's Disease, 2016Alzheimer's disease (AD) is the most common form of dementia. Although the pathogenesis of AD remains unclear, AD is thought to result from an imbalance in the production and clearance of amyloid-β protein (Aβ). Aquaporin-4 (AQP4) is the major aquaporin in the mammalian brain, is mostly expressed on astrocytic endfeet, and functions as a water ...
Hantao Mai +7 more
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The role of aquaporin 4 in the brain
Veterinary Clinical Pathology, 2012Abstract:Emerging evidence suggests that aquaporin (AQP) 4 water channels play an important role in water homeostasis in the brain. These water channels are most abundant in the cell membrane of astrocytes, but are also present within ependymal cell membranes and in osmosensory areas of the hypothalamus.
Christine Iacovetta +2 more
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Hydrocephalus and Aquaporins: The Role of Aquaporin-4
2011Aquaporins (AQPs) are membrane proteins that facilitate water and small solute movement in tissues. Hydrocephalus is the major central nervous system disorder associated with defective cerebrospinal fluid turnover. Aquaporin-4 (AQP4) is a water channel located mainly at the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) interfaces and is
Aristotelis S. Filippidis +2 more
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Aquaporin-4 in hepatic encephalopathy
Metabolic Brain Disease, 2007Brain edema is a critical component of hepatic encephalopathy (HE) associated with acute liver failure and such edema appears to be principally due to astrocyte swelling (cytotoxic edema). Ammonia is believed to represent a major factor responsible for astrocyte swelling, although the mechanisms by which ammonia causes such swelling are not completely ...
K. V. Rama Rao +2 more
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Aquaporins, anti-aquaporin-4 autoantibodies and neuromyelitis optica
Clinica Chimica Acta, 2013The classification, distribution and functions of the different molecules of aquaporins (AQPs), including aquaporins, aquaglyceroporins and superaquaporins are reviewed together with their potential diagnostic and therapeutic uses. We analyzed the pathogenic importance of anti-AQP4 autoantibodies in neuromyelitis optica and related syndromes, as well ...
José Manuel González-Buitrago +2 more
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Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin‐4
The FASEB Journal, 2004Aquaporin-4 (AQP4) is the major water channel of the neuromuscular system, but its physiological function in both perivascular astrocytes and skeletal muscle sarcolemma is unclear. The purpose of this study was to assess the following in skeletal muscle: a) the expression of all cloned water cannels; b) the functional role of AQP4 using sarcolemma ...
FRIGERI, Antonio +4 more
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Aquaporin-4 autoantibodies cause asymptomatic aquaporin-4 loss and activate astrocytes in mouse
Journal of Neuroimmunology, 2012Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse of NMO are uncertain.Study the pathogenicity of AQP4 Ab in the absence of complement activation.Female C57BL/6N ...
Chan, KH +6 more
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