H95 Is a pH-Dependent Gate in Aquaporin 4 [PDF]
Structure, 2015 Aquaporin 4 (AQP4) is a transmembrane protein from the aquaporin family and is the predominant water channel in the mammalian brain. The regulation of permeability of this protein could be of potential therapeutic use to treat various forms of damage to the nervous tissue.
Kaptan, Shreyas +6 more
openaire +6 more sources
Congestive heart failure in rats is associated with increased expression and targeting of aquaporin-2 water channel in collecting duct [PDF]
, 1997 We tested whether severe congestive heart failure (CHF), a condition associated with excess free-water retention, is accompanied by altered regulation of the vasopressin-regulated water channel, aquaporin-2 (AQP2), in the renal collecting duct.
Andersen, D. +8 more
core +2 more sources
Evaluation of aquaporin‐4 antibody assays [PDF]
Clinical and Experimental Neuroimmunology, 2014 AbstractAquaporin‐4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica‐immunoglobulin G (NMO‐IgG, or AQP4‐IgG), an antibody found specifically in patients with NMO and in formes frustes of NMO, such as ...
Jeffrey Bennett +5 more
openaire +3 more sources
UNDULY ENHANCED RESPONSE TO TOLVAPTAN IN A WOMAN SHOWING SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE SECRETION: AN INVESTIGATION OF POSSIBLE CAUSES [PDF]
, 2017 Objective: To investigate possible causes of an excessive response to tolvaptan in a woman with syndrome of inappropriate antidiuretic hormone secretion (SIADH).
Lanzellotti, Davide +4 more
core +1 more source
Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels
Molecular Neurobiology, 2020 Aquaporin-4 (AQP4) is located mainly in the astrocytic end-feet around cerebral blood vessels and regulates ion and water homeostasis in the brain. While deletion of AQP4 is shown to reduce amyloid-β (Aβ) clearance and exacerbate Aβ peptide accumulation ...
G. Rosu +6 more
semanticscholar +1 more source
Modified Kedem-Katchalsky equations for osmosis through nano-pore
, 2016 This work presents a modified Kedem-Katchalsky equations for osmosis through nano-pore. osmotic reflection coefficient of a solute was found to be chiefly affected by the entrance of the pore while filtration reflection coefficient can be affected by ...
Huang, Suyi +6 more
core +1 more source
Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009 [PDF]
, 2010 This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the
Bartholomaus I. +44 more
core +1 more source
Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. [PDF]
, 2016 OBJECTIVE: To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.
Alper, G +14 more
core +1 more source
ASN Neuro, 2020 In ischemic stroke, vasopressin hypersecretion is a critical factor of cerebral swelling and brain injury. To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle ...
Dan Cui +9 more
doaj +1 more source
Aquaporin 4 expression is downregulated in large bovine ovarian follicles
Journal of Animal Reproduction and Biotechnology, 2020 Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim +5 more
doaj +1 more source